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Biopolymers: Applications in wound healing and skin tissue engineering

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Abstract

Wound is a growing healthcare challenge affecting several million worldwide. Lifestyle disorders such as diabetes increases the risk of wound complications. Effective management of wound is often difficult due to the complexity in the healing process. Addition to the conventional wound care practices, the bioactive polymers are gaining increased importance in wound care. Biopolymers are naturally occurring biomolecules synthesized by microbes, plants and animals with highest degree of biocompatibility. The bioactive properties such as antimicrobial, immune-modulatory, cell proliferative and angiogenic of the polymers create a microenvironment favorable for the healing process. The versatile properties of the biopolymers such as cellulose, alginate, hyaluronic acid, collagen, chitosan etc have been exploited in the current wound care market. With the technological advances in material science, regenerative medicine, nanotechnology, and bioengineering; the functional and structural characteristics of biopolymers can be improved to suit the current wound care demands such as tissue repair, restoration of lost tissue integrity and scarless healing. In this review we highlight on the sources, mechanism of action and bioengineering approaches adapted for commercial exploitation.

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Abbreviations

ECM:

Extracellular matrix

PDGF:

Platelet derived growth factor

VEGF:

Vascular endothelial growth factor

TGF-β:

Transforming growth factor-β

EGF:

Epidermal growth factor

RGD:

Arginine glycine and aspartate

MMP:

Matrix metalloproteinases

TIMP:

Tissue inhibitor of metalloproteinases

PCL:

Polycaprolactone

PVA:

Polyvinylalcohol

PLGA:

Poly(lactic-co-glycolic acid)

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Acknowledgements

Sahana T. G. acknowledges DST-INSPIRE fellowship.

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  1. Yenepoya Research Centre, Yenepoya University, University Road, Deralakatte, Mangalore, 575018, India

    T. G. Sahana & P. D. Rekha

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  1. T. G. Sahana
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Sahana, T.G., Rekha, P.D. Biopolymers: Applications in wound healing and skin tissue engineering. Mol Biol Rep 45, 2857–2867 (2018). https://doi.org/10.1007/s11033-018-4296-3

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