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Oral Delivery of Lactoferrin: A Review

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International Journal of Peptide Research and Therapeutics Aims and scope Submit manuscript

Abstract

Lactoferrin (Lf), as a therapeutic protein drug, has attracted much interest due to its many important roles in human and animal health and development. Oral delivery offers the most convenient way for supplementing Lf. However, the bioavailability of orally administered Lf is limited by a number of barriers associated with protein absorption. During the past decade, several oral delivery systems have been developed to preserve Lf stability in order to enhance gastric residence time and improve its bioavailability. This review summarizes various pharmaceutical strategies currently under investigation including: PEGylation, absorption enhancers, enzymatic inhibitors and advanced drug carrier systems.

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Acknowledgments

The present study was financially supported by a Faculty Research Development Fund (FRDF) from The University of Auckland’s Faculty of Medical and Health Science.

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  1. Jingyuan Wen

    Present address: School of Pharmacy, Faculty of Medical and Health Science, University of Auckland, Auckland, 1142, New Zealand

Authors and Affiliations

  1. School of Pharmacy, Faculty of Medical and Health Science, University of Auckland, Auckland, 1142, New Zealand

    Xudong Yao

  2. Faculty of Agriculture and Life Science, Lincoln University, Canterbury, 7647, New Zealand

    Craig Bunt

  3. School of Medicine, Faculty of Medical and Health Science, University of Auckland, Auckland, 1142, New Zealand

    Jillian Cornish

  4. Food Science, Faculty of Science, University of Auckland, Auckland, 1142, New Zealand

    Siew-Young Quek

Authors
  1. Xudong Yao
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  2. Craig Bunt
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  3. Jillian Cornish
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  4. Siew-Young Quek
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  5. Jingyuan Wen
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Correspondence to Jingyuan Wen.

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Yao, X., Bunt, C., Cornish, J. et al. Oral Delivery of Lactoferrin: A Review. Int J Pept Res Ther 19, 125–134 (2013). https://doi.org/10.1007/s10989-012-9326-8

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  • DOI: https://doi.org/10.1007/s10989-012-9326-8

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