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Characterization and compatibility of dry extract from Annona muricata L. and pharmaceutical excipients

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Abstract

The aim of this study was to characterize and evaluate the compatibility of the dry extract (DE) of leaves of Annona muricata L. with pharmaceutical excipients usually used in the manufacturing of medicines. Characterization of the DE and binary mixtures of the extract and excipients was carried out using scanning electron microscopy (SEM), differential scanning calorimetry, thermogravimetry (TG) and Fourier transform infrared attenuated total reflection spectroscopy. Spray drying technique produced extract to form spherical and hollow particles revealed by SEM, with four stages of mass loss in the TG curve. Pre-formulation study showed compatibility between the extract and microcrystalline cellulose, lactose, croscarmellose sodium and sodium starch glycolate. New medicines containing herbal drugs enter the market every year, and our study demonstrates that thermoanalytical techniques can be used in the development and quality control of herbal medicines.

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Acknowledgements

This study was financed in part by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior—Brasil (CAPES)—Finance Code 001.

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Authors and Affiliations

  1. Department of Pharmaceutical Sciences, Postgraduate Program in Pharmaceutical Sciences, Federal University of Pernambuco, University City, Artur de Sá Avenue, Recife, PE, 50740-521, Brazil

    Fabrício Havy Dantas de Andrade, Rui Oliveira Macedo & Almir Gonçalves Wanderley

  2. Unified Laboratories of Pharmaceutical Development and Assays, Pharmaceutical Sciences Department, Federal University of Paraíba - UFPB, Campus I, University City s/n, Castelo Branco III, João Pessoa, PB, 58059-900, Brazil

    Fabrício Havy Dantas de Andrade, Rayanne Sales de Araújo Batista, Taynara Batista Lins Melo, Rui Oliveira Macedo & Fábio Santos de Souza

  3. Pharmacy Department, FCM, UNIFACISA - University Center, Av. Senador Argemiro de Figueiredo, 1901, Itararé, Campina Grande, PB, 58411-020, Brazil

    Felipe Hugo Alencar Fernandes

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  1. Fabrício Havy Dantas de Andrade
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Correspondence to Fabrício Havy Dantas de Andrade.

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de Andrade, F.H.D., de Araújo Batista, R.S., Melo, T.B.L. et al. Characterization and compatibility of dry extract from Annona muricata L. and pharmaceutical excipients. J Therm Anal Calorim 143, 237–246 (2021). https://doi.org/10.1007/s10973-019-09159-8

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  • DOI: https://doi.org/10.1007/s10973-019-09159-8

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