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Characterization of solid dispersions of a powerful statin using thermoanalytical techniques

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Abstract

One of the major challenges for the development of drugs containing active pharmaceuticals ingredient (API) with low solubility is to add technologies to the development process in order to increase bioavailability while ensuring stability. Thus, the main objective of this work was to apply analytical methodologies in the characterization and stability of solid dispersions of atorvastatin calcium obtained by different techniques. The calorimetric curves showed different thermal profiles for the dispersions, presenting a greater interaction of the components, the SD-PEG sd. Moreover, the thermogravimetric curves showed that the PEG conferred greater stability to the dispersions. The FTIR/Pearson correlation and PXRD data revealed neither chemical interaction nor intense amorphization in the solid dispersions, respectively. Additionally, it was concluded the thermoanalytical techniques are useful, complementary, and elucidative in the characterization of the physical–chemical nature of the solid dispersions obtained by lyophilization and spray drying, providing reliable results regarding the thermal behavior and the solubility of the samples.

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Acknowledgements

The authors would like to thank the “Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)” and the “Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)” for supporting this work. Additionally, the authors would like to thank Felipe Ramos for support to translate this manuscript.

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  1. Department of Pharmaceutical Sciences, Postgraduate Program in Pharmaceutical Sciences, Universidade Federal de Pernambuco, Artur de Sá Avenue, Recife, 50740-521, Brazil

    Karla Monik Alves da Silva, Fernando José de Lima Ramos Júnior, Deysiane Oliveira Brandão & Rui Oliveira Macêdo

  2. Unified Laboratories of Pharmaceutical Development and Assays, Department of Pharmaceutical Sciences, Universidade Federal da Paraíba, Campus I, Cidade Universitária, João Pessoa, PB, 58059-970, Brazil

    Karla Monik Alves da Silva, Fernando José de Lima Ramos Júnior, José Venâncio Chaves Júnior, Deysiane Oliveira Brandão, Taynara Batista Lins, Rui Oliveira Macêdo & Fábio Santos de Souza

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da Silva, K.M.A., de Lima Ramos Júnior, F.J., Júnior, J.V.C. et al. Characterization of solid dispersions of a powerful statin using thermoanalytical techniques. J Therm Anal Calorim 138, 3701–3714 (2019). https://doi.org/10.1007/s10973-019-08450-y

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