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The kinetic study of the thermally induced degradation and an evaluation of the drug–excipient interactions performed for a new-generation bisphosphonate—risedronate

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Abstract

Sodium risedronate (Rise) is a third generation of bisphosphonates, compounds active in suppressing the bone resorption and therefore used in orthopedy, dentistry and bone cancer treatment. The stability of Rise as bioactive compound was studied by thermoanalysis (TA) and kinetic analysis under non-isothermal conditions, as well as by FTIR spectroscopy of samples treated at different temperatures. The data were compared with these obtained for similar compounds (sodium alendronate and zoledronic acid) and reveal a low stability: The decomposition begins under 100 °C, and the activation energy is relatively small. The possibilities of increasing the thermal stability were studied using binary mixture (1:1) in mass parts of Rise with talc, silica, mannitol, starch, microcrystalline cellulose and magnesium stearate. By both methods, TA and FTIR interaction between Rise and mannitol was detected. Regarding the kinetic analysis, the nonparametric kinetic methods reveal its advantages by an objective and complete kinetic description of Rise thermal decomposition.

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Authors and Affiliations

  1. Research Center for Thermal Analysis in Environmental Problems, West University of Timisoara, 16 Pestalozzi St, 300115, Timisoara, Romania

    Gabriela Vlase, Paul Albu, Madalina Mateescu & Titus Vlase

  2. Faculty of Medicine, University of Medicine and Pharmacy “Victor Babes”, Eftimie Murgu Square 2, 300041, Timisoara, Romania

    Sorin Cristian Doca

Authors
  1. Gabriela Vlase
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  2. Paul Albu
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  3. Sorin Cristian Doca
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  4. Madalina Mateescu
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  5. Titus Vlase
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Correspondence to Titus Vlase.

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Vlase, G., Albu, P., Doca, S.C. et al. The kinetic study of the thermally induced degradation and an evaluation of the drug–excipient interactions performed for a new-generation bisphosphonate—risedronate. J Therm Anal Calorim 134, 721–730 (2018). https://doi.org/10.1007/s10973-018-7216-9

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  • DOI: https://doi.org/10.1007/s10973-018-7216-9

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