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Compatibility study between atorvastatin and excipients using DSC and FTIR

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Abstract

The aim of this study was to characterize atorvastatin and evaluate interactions between atorvastatin and various excipients by DSC and FTIR, using Pearson’s correlation as a tool to corroborate possible interactions that it was not possible to evidence in visual analyses. The DSC curves were obtained using a Shimadzu calorimeter, Model DSC-60, in the aluminum crucible under heating rate of 20 °C min−1 at a temperature of 25–400 °C. The spectra of the samples were obtained on a FTIR–ATR model IR prestige-21 Shimadzu spectrophotometer at a wavelength of 700–4000 cm−1 on average of 20 scans. The theoretical spectrum was obtained using an ad hoc algorithm. From the analysis of DSC and evaluation of Pearson’s correlation, it observed physical interactions with excipients: starch glycolate, pre-gelatinized starch, croscarmellose, sodium lauryl sulfate, magnesium stearate and mannitol. There is no interaction with lactose. Then, the Pearson’s correlation was so important tool to evaluate possible interactions between IPAs and excipients, using FTIR data to corroborate DSC results.

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References

  1. Oliveira MA, Yoshida MI, Belinelo VJ, Valotto RS. Degradation kinetics of atorvastatin under stress conditions and chemical analysis by HPLC. Molecules. 2013;18:1447–56.

    Article  CAS  Google Scholar 

  2. United State Pharmacopeial, The United States Pharmacopeial Convention. United States Pharmacopeia. 34th ed. Rockville (MD, USA): The United States Pharmacopeial Convention, 2010.

  3. Zerbini APN. Desenvolvimento e avaliação de minicomprimidos contendo atorvastatina cálcica. Universidade de São Paulo, 2010.

  4. Mendonça CMS, Lima IPB, Aragão CFS, Gomes APB. Thermal compatibility between hydroquinone and retinoic acid in pharmaceutical formulations. J Therm Anal Calorim. 2013. doi:10.1007//s10973-013-2941-6.

    Google Scholar 

  5. Freire FD, Aragão CF, Lima TFA, Raffim FN. Compatibility study between chlorpropamide and excipients in their physical mixtures. J Therm Anal Calorim. 2009;97:355–7.

    Article  CAS  Google Scholar 

  6. Tomassetti M, Catalani A, Rossi V, Vecchio S. Thermal analysis study of the interactions between acetaminophen and excipients in solid dosage forms and in some binary mixtures. J Pharm Biomed Anal. 2005;37:949–55.

    Article  CAS  Google Scholar 

  7. Bertol CD, Cruz AP, Stulzer HK, Murakami FS, Silva MAS. Thermal decomposition kinetics and compatibility studies of primaquine under isothermal and non-isothermal conditions. J Therm Anal Calorim. 2010;102:187–92.

    Article  CAS  Google Scholar 

  8. Pinto MF, Moura EA, Souza FS, Macêdo RO. Thermal compatibility studies of nitroimidazoles and excipients. J Therm Anal Calorim. 2010;102:323–9.

    Article  CAS  Google Scholar 

  9. Moyano MA, Broussalis AM, Segall AI. Thermal analysis of lipoic acid and evaluation of the compatibility with excipientes. J Therm Anal Calorim. 2010;99:631–7.

    Article  CAS  Google Scholar 

  10. Peres-Filho MJ, Gaeti MPN, Oliveira SR, Marreto RN, Lima EM. Thermoanalytical investigation of olanzapine compatibility with excipients used in solid oral dosage forms. J Therm Anal Calorim. 2011;104:255–60.

    Article  CAS  Google Scholar 

  11. Song VM, Kumar L, Puri V, Kohli G, Kaushal AM, Bansal A. Effect of counterions on the properties of amorphous atorvastatin salts. Eur J Pharm Sci. 2011;44:462–70.

    Article  CAS  Google Scholar 

  12. Zhang HX, Wang JX, Zhang ZB, LE Y, Shen ZG, Chen JF. Micronization of atorvastatin calcium by antisolvent precipitation process. Int J Pharm. 2009;374:106–13.

    Article  CAS  Google Scholar 

  13. Jin YS, Ulrich J. New Crystalline Solvates of Atorvastatin Calcium. Chem Eng Technol. 2010;33(5):839–44.

    Article  CAS  Google Scholar 

  14. Lima IPB, Lima NGPB, Barros DMCB, Oliveira TSO, Barbosa EG, Gomes APB, Ferrari M, Nascimento TGN, Aragão CFS. Compatibility study of tretinoin with several pharmaceutical excipients by thermal and non-thermal techniques. J Therm Anal Calorim. 2015;120:733–47. doi:10.1007/s10973-014-4295-0.

    Article  CAS  Google Scholar 

  15. An SG, Sohn YT. Crystal forms of atorvastatin. Arch Pharm Res. 2009;32(6):933–6. doi:10.1007/s12272-009-1616-0933.

    Article  CAS  Google Scholar 

  16. Carvalho KP, Rocha TC, Leles MIG. Characterization of atorvastatin by TG and DSC. Braz J Therm Anal. 2012;1:79–83.

    Google Scholar 

  17. Kim MS, Jin SJ, Kim JS, Park HJ, Song HS, Neubert RHH, Hwang SJ. Preparation, characterization and in vivo evaluation of amorphous atorvastatin calcium nanoparticles using supercritical antisolvent (SAS) process. Eur J Pharm Biopharm. 2008;69(2):454–65.

    Article  CAS  Google Scholar 

  18. Yoshida MI, Oliveira MA, Lacerda CD, Bonella AF, Valotto RS. Caracterização Térmica da Atorvastatina e Estudos de Compatibilidade de Formulações Farmacêuticas. Br J Thermal Anal. 2012;1:73–8.

    Google Scholar 

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Authors and Affiliations

  1. Laboratory Quality Control (LCQMed), Pharmaceutical Sciences Department, Federal University of Rio Grande do Norte – UFRN, Av, General Cordeiro de Faria s/n, Petrópolis, Natal, Rio Grande do Norte, 59078-970, Brazil

    Edilamar Pereira da Silva, Maxciara Agda Vicente Pereira, Igor Prado de Barros Lima, Naiana Gondim Pereira Barros Lima, Euzébio Guimarães Barbosa, Cícero Flávio Soares Aragão & Ana Paula Barreto Gomes

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  1. Edilamar Pereira da Silva
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  2. Maxciara Agda Vicente Pereira
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  3. Igor Prado de Barros Lima
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  4. Naiana Gondim Pereira Barros Lima
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  5. Euzébio Guimarães Barbosa
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  6. Cícero Flávio Soares Aragão
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  7. Ana Paula Barreto Gomes
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Correspondence to Ana Paula Barreto Gomes.

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da Silva, E.P., Pereira, M.A.V., de Barros Lima, I.P. et al. Compatibility study between atorvastatin and excipients using DSC and FTIR. J Therm Anal Calorim 123, 933–939 (2016). https://doi.org/10.1007/s10973-015-5077-z

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  • DOI: https://doi.org/10.1007/s10973-015-5077-z

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