Skip to main content
SpringerLink
Log in

A DSC study of some biomaterials relevant to pharmaceutical industry

  • Published:
Journal of Thermal Analysis and Calorimetry Aims and scope Submit manuscript

Abstract

The present investigation concerns with thermal analysis of biomaterials such as Chitosan, Xanthan gum, Guar gum Pectin, Karaya gum, Sodium alginate, and Psyllium husk mucilage. The DSC curve of the natural polymers showed its specific endothermic peaks and ΔH f values, and these will be helpful in determining the fitness of the polymers with active drug. The drug and natural polymer compatibility study is now one of the recognized methods for preformulation step in pharmaceutical drug development. All the natural polymers showed endothermic peak below 150 °C, and this make them suitable with a wide class of therapeutic drugs.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

References

  1. Gohel MC, Patel TM. Compatibility study of quetiapine fumarate with widely used sustained release excipients. J Therm Anal Calorim. 2012. doi:10.1007/s10973-012-467-3.

  2. Nep EI, Conway BR. Preformulation studies on grewia gum as a formulation excipient. J Therm Anal Calorim. 2012;108(1):197–205.

    Article  CAS  Google Scholar 

  3. Prabaharan M, Mano JF. Chitosan-based particles as controlled drug delivery systems. Drug Deliv. 2005;12(1):41–57.

    Article  CAS  Google Scholar 

  4. Prabaharan M. Chitosan derivatives as promising materials for controlled drug delivery. J Biomater Appl. 2008;23(1):5–36.

    Article  CAS  Google Scholar 

  5. Patel MP, Patel RR, Patel JK. Chitosan mediated targeted drug delivery system: a review. J Pharm Pharm Sci. 2010;13(4):536–57.

    CAS  Google Scholar 

  6. Singh B. Psyllium as therapeutic and drug delivery agent. Int J Pharm. 2007;334(1–2):1–14.

    Article  CAS  Google Scholar 

  7. Shirsand SB, Suresh S, Para MS, Swamy PV, Kumar ND. Plantago ovata mucilage in the design of fast disintegrating tablets. Indian J Pharm Sci. 2009;71(1):41–5.

    Google Scholar 

  8. Saeedi M, Morteza-semnani K, Ansoroudi F, Fallah S, Amin G. Evaluation of binding properties of Plantago psyllium seed mucilage. Acta Pharm. 2010;60(3):339–48.

    Article  Google Scholar 

  9. Sriamornsak P. Application of Pectin in oral drug delivery. Expert Opin Drug Deliv. 2011;8(8):1009–23.

    Google Scholar 

  10. Thakur BR, Singh RK, Handa AK. Chemistry and uses of Pectin—a review. Crit Rev Food Sci Nutr. 1997;37(1):47–53.

    Article  CAS  Google Scholar 

  11. Chudzikowski RJ. Guar gum and its applications. J Soc Cosmet Chem. 1971;22:43–60.

    CAS  Google Scholar 

  12. Andreopoulos AG, Tarantili PA. Xanthan gum as a carrier for controlled release of drugs. J Biomater Appl. 2001;16(1):34–46.

    Article  CAS  Google Scholar 

  13. Reddy MS, Reddy JD, Moin A, Shivakumar HG. Formulation of sustained-release matrix tablets using cross-linked Karaya gum. Trop J Pharm Res. 2012;11(2):185–92.

    Article  Google Scholar 

  14. Chivate AA, Poddar SS, Abdul S, Savant G. Evaluation of Sterculia foetida gum as controlled release excipient. AAPS PharmSciTech. 2008;9(1):197–204.

    Article  CAS  Google Scholar 

  15. Senapati MK, Srinatha A, Pandit JK. In vitro release characteristics of matrix tablets: study of Karaya gum and Guar gum as release modulators. Indian J Pharm Sci. 2006;68:824–26.

    Article  CAS  Google Scholar 

  16. Liew CV, Chan LW, Ching AL, Wan P, Heng S. Evaluation of Sodium alginate as drug release modifier in matrix tablets. Int J Pharm. 2006;309(1–2):25–37.

    Article  CAS  Google Scholar 

  17. Tønnesen HH, Karlsen J. Alginate in drug delivery systems. Drug Dev Ind Pharm. 2002;28(6):621–30.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pharmaceutical Sciences, Dibrugarh University, Dibrugarh, 786004, Assam, India

    Akhilesh Vikram Singh

Authors
  1. Akhilesh Vikram Singh
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Akhilesh Vikram Singh.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Singh, A.V. A DSC study of some biomaterials relevant to pharmaceutical industry. J Therm Anal Calorim 112, 791–793 (2013). https://doi.org/10.1007/s10973-012-2638-2

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10973-012-2638-2

Keywords

Search

Navigation