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Thermal stability of ketoprofen

Part 2. Kinetic study of the active substance under isothermal conditions

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Abstract

The purpose of this investigation is to calculate the kinetic parameters and the kinetic model for the studied process. The results are further used to predict the system’s behaviour in various circumstances. A kinetic study regarding the ketoprofen—involving active substance’s thermal decomposition—was performed under isothermal conditions and in a nitrogen atmosphere, for the temperature steps: 260; 265; 270; 275; and 280 °C. The thermogravimetry/derivative thermogravimetry data were processed by three differential methods: isothermal–isoconversional, Friedman’s isothermal–isoconversional, and isothermal model-fittings. The obtained results are in good accordance with those obtained under non-isothermal conditions of a previous study, and confirm the necessity for the kinetic parameters to be determined, under different thermal conditions, by the adequate calculation methods.

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Authors and Affiliations

  1. “Victor Babeş”, Faculty of Pharmacy, University of Medicine and Pharmacy, Eftimie Murgu Square 2, 300041, Timisoara, Romania

    Dumitru Tiţa, Adriana Fuliaş & Bogdan Tiţa

Authors
  1. Dumitru Tiţa
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  2. Adriana Fuliaş
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  3. Bogdan Tiţa
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Correspondence to Adriana Fuliaş.

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Tiţa, D., Fuliaş, A. & Tiţa, B. Thermal stability of ketoprofen. J Therm Anal Calorim 111, 1979–1985 (2013). https://doi.org/10.1007/s10973-011-2147-8

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