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Sol–gel synthesis of mesoporous silicas containing albumin and guanidine polymers and its application to the bilirubin adsorption

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Abstract

The organic–inorganic composite materials based on mesoporous silica were synthesized using sol–gel method. The surface area of silicas was modified by bovine serum albumin (BSA) and guanidine polymers: polyacrylate guanidine (PAG) and polymethacrylate guanidine. The mesoporous silicas were characterized by nitrogen adsorption–desorption analysis, Fourier transform infrared spectroscopy, transmission electron microscopy. The obtained materials were used as adsorbents for selective bilirubin removal. It was shown that the structural properties and surface area of modified materials depend on the nature of polymers. Incorporation of polymers in silica gel matrix during sol–gel process leads to the formation of mesoporous structure with high pore diameter and a BET surface area equals to 346 m2/g for SiO2/BSA and 160 m2/g for SiO2/PAG. Analysis of adsorption isotherms showed that modification of silica by BSA and guanidine polymers increases its adsorption ability to bilirubin molecules. According to Langmuir model, the maximum bilirubin adsorption capacity was 1.18 mg/g.

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Acknowledgments

We thank Dr. Khashirova S. Yu., department of macromolecular compounds, the Kabardino-Balkar State University by N.M. Berbekova, for synthesis of guanidine polymers. The work is supported by the Grant of the RFBR (Project No. 12-03-31309).

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  1. Department of Inorganic Chemistry, Ivanovo State University of Chemistry and Technology (ISUCT), 7, Sheremetevsky prosp., Ivanovo, Russian Federation

    A. S. Timin & E. V. Rumyantsev

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  1. A. S. Timin
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  2. E. V. Rumyantsev
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Correspondence to A. S. Timin.

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Timin, A.S., Rumyantsev, E.V. Sol–gel synthesis of mesoporous silicas containing albumin and guanidine polymers and its application to the bilirubin adsorption. J Sol-Gel Sci Technol 67, 297–303 (2013). https://doi.org/10.1007/s10971-013-3079-5

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  • DOI: https://doi.org/10.1007/s10971-013-3079-5

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