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Hyaluronic acid-modified [19F]FDG-conjugated magnetite nanoparticles: in vitro bioaffinities and HPLC analyses in organs

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Abstract

In this study, we designed and synthesized [19F]FDG-(2-deoxy-2-[fluorine-19]fluoro-d-glucose) conjugated iron oxide magnetic nanoparticles ([19F]FDG-MNPs) for hybrid imaging and hyperthermia treatment. MNPs were synthesized, silica coated, and fabricated with TEOS (tetraethyl orthosilicate). They were then covered with hyaluronic acid (HA) to enhance their bioavailability. The modified MNPs were conjugated with [19F]FDG and optically labeled with ICG (indocyanine green). The in vitro bioaffinities were surveyed in MCF7 and PC3 cell lines. In vivo bioaffinies were determined using Sprague–Dawley rats.

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Acknowledgements

The authors wish to thank Dr. Omer Aras for their assistance in the TEM Image of FDG MNPs. The work is MS thesis of Volkan Yasakçı from Graduate School of Natural and Applied Sciences and has been partially presented at EANM’17—Annual Congress of the European Association of Nuclear Medicine, October 21–25, 2017 in Vienna/Austria.

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Authors and Affiliations

  1. Department of Nuclear Applications, Institute of Nuclear Sciences, Ege University, 35100, Bornova, Izmir, Turkey

    Volkan Yasakci, Volkan Tekin, Ozge Kozgus Guldu & Perihan Unak

  2. Department of Physiology, Faculty of Medicine, Ege University, Bornova, Izmir, Turkey

    Vedat Evren

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  1. Volkan Yasakci
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  2. Volkan Tekin
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  3. Ozge Kozgus Guldu
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Correspondence to Perihan Unak.

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Yasakci, V., Tekin, V., Guldu, O.K. et al. Hyaluronic acid-modified [19F]FDG-conjugated magnetite nanoparticles: in vitro bioaffinities and HPLC analyses in organs. J Radioanal Nucl Chem 318, 1973–1989 (2018). https://doi.org/10.1007/s10967-018-6282-6

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  • DOI: https://doi.org/10.1007/s10967-018-6282-6

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