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Synthesis, development and preclinical study of EDDA based 99mTc-5-fluorouracil for brain imaging

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Abstract

5-Fluorouracil is used as an antineoplastic agent in solid tumors. The study was conducted to analyze the effect of EDDA on synthesis of 5-fluorouracil with 99mTc. The 99mTc-5-flurouracil was formulated using stannous agent, and EDDA. This complex was stable for 4 h, with post labeling efficiency of 92 %. The distribution study in animal model showed that after 30 min 35 ± 8 % of injected dose cross the blood brain barrier and excreted through kidney with no sign of toxicity. It was concluded that the addition of EDDA modified the labeling side in 5-fluorouracil for 99mTc, which localized in brain and hence can be used further for brain imaging study.

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Authors and Affiliations

  1. Department of Biotechnology, Quaid-I-Azam University, Islamabad, Pakistan

    N. Ahmed & M. Zia

  2. Department of Nuclear Medicine, Nuclear Medicine, Oncology and Radiotherapy Institute (NORI), Hanna Road G-8/3, Islamabad, Pakistan

    N. Ahmed, A. M. Saeed, S. Fatima & J. Irfan

  3. Department of Pharmacy, University of Peshawar, Peshawar, Pakistan

    N. Zia

  4. Department of Diagnostic Laboratory, Nuclear Medicine, Oncology and Radiotherapy Institute (NORI), Hanna Road G-8/3, Islamabad, Pakistan

    A. Raza

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  1. N. Ahmed
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  2. A. M. Saeed
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  3. S. Fatima
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  4. N. Zia
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  5. A. Raza
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Correspondence to N. Ahmed.

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Ahmed, N., Saeed, A.M., Fatima, S. et al. Synthesis, development and preclinical study of EDDA based 99mTc-5-fluorouracil for brain imaging. J Radioanal Nucl Chem 309, 805–811 (2016). https://doi.org/10.1007/s10967-015-4690-4

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  • DOI: https://doi.org/10.1007/s10967-015-4690-4

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