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Lipophilic effect of various pluronic-grafted gelatin copolymers on the quercetin delivery efficiency in these self-assembly nanogels

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Abstract

In this study, pluronics (P123, F127, F87 and F68) and their gelatin modified pluronic (GP) forms (GP-P123, GP-F127, GP-F87 or GP-F68) were used to investigate the effect of gelatin conjugation as well as the lipophilic properties of each pluronic on quercetin (QU) delivery. The anti-cancer property of QU was also evaluated using breast cancer (MCF-7) and cervical cancer (HeLa) cell lines. The QU are encapsulated in the GP nanogels via self-assembly process. Their structures were characterized by 1H-NMR and TGA. All GP nanogels performed significant higher loading efficiency compared to bare pluronic form. The size distribution of the QU-loaded GP nanogels ranged from 79.52 ± 3.22 nm to 152.51 ± 4.97 nm. The study interestingly shows that of the grafted pluronic induced the QU loading efficiency due to its higher hydrophobicity. Indeed, pluronic P123-grafted gelatin exhibited the highest QU entrapment efficiency of up to 93.02 ± 3.7%. Our obtained results indicated that the QU-loaded GP nanogels performed a sustained release ability of QU compared to pluronic-based micelles. The QU-loaded GP-P123 system performed higher activity against growth of HeLa and MCF7 cancer cell lines compared to the free QU. The preliminary results could offer a further study via co-encapsulation of the QU and anti-cancer drugs for enhancing effectiveness in chemotherapy.

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Acknowledgements

This work was funded by Vietnam National Foundation for Science and Technology Development (NAFOSTED) under grant number 104.02-2017.60.

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Authors and Affiliations

  1. Institute of Fundamental and Applied Sciences, Duy Tan University, Da Nang, 550000, Vietnam

    Dinh Van Thoai & Nguyen Van Toan

  2. Graduate University of Science and Technology, Vietnam Academy of Science and Technology, HCMC, Vietnam

    Dinh Van Thoai, Dinh Trung Nguyen & Tran Ngoc Quyen

  3. Institute of Applied Materials Science Vietnam Academy of Science and Technology, HCMC, Vietnam

    Dinh Trung Nguyen, Ngoc Hao Nguyen, Phuong Doan & Tran Ngoc Quyen

  4. Department of Natural Science, Thu Dau Mot University, Thu Dau Mot City, 590000, Vietnam

    Le Hang Dang, Bich Tram Nguyen &  Le Van Thu

  5. Center for Research and Technology Transfer, Vietnam Academy of Science and Technology, Hanoi, Vietnam

    Nguyen Ngoc Tung

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  1. Dinh Van Thoai
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Van Thoai, D., Nguyen, D.T., Dang, L.H. et al. Lipophilic effect of various pluronic-grafted gelatin copolymers on the quercetin delivery efficiency in these self-assembly nanogels. J Polym Res 27, 369 (2020). https://doi.org/10.1007/s10965-020-02216-z

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