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pH-responsive polymeric nanoassemblies encapsulated into alginate beads: morphological characterization and swelling studies

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Abstract

The aim of this study is to design and develop novel hybrid pH-responsive hydrogels. For this purpose, new copolymers with different molecular weights and different content of the hydrophobic part are synthesized. The self-assembly behavior of PSMA-co-PDMAEMA copolymerswasstudiedin two different dispersion media (simulated gastric fluid-SGF, pH = 1.2 and simulated intestinal fluid-SIF, pH = 6.8) and in different concentrations. The physicochemical characteristics of the nano-assemblies were found to be dependent on the composition of the copolymer and the aqueous environment. Having a complete knowledge of the self-assembly behavior of the copolymers in aqueous media, the encapsulation of the PSMA-co-PDMAEMA 1/2 nano-assemblies into Alginate beads was achieved by following the protocol of the preparation of hydrogels. The Calcium:Alginate hydrogels were used as reference systems for comparison reasons. The size and the morphology of pure and mixed beads were found to be dependent on the composition of the block copolymer, as revealed from SEM images. The behavior of the mixed hydrogels was the same during the swelling studies, but the rate of the swelling and the amount of weight change were found to be additionally dependent on the composition of the polymeric guest. The hydration state of the polymeric chains plays a key role inthe swelling behavior of the mixed hydrogels. In conclusion, pH-responsive hybrid hydrogels were developed and their behavior and morphology are strongly dependent on the molecular characteristics of the polymeric guest.

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Acknowledgements

This study was funded as Scholarship – Grant by the Experimental- Research Center ELPEN (E.R.C.E) and the Hellenic Society of Biomaterials.

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Authors and Affiliations

  1. Section of Pharmaceutical Technology, Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Panepistimioupolis Zografou, 15771, Athens, Greece

    Natassa Pippa & Costas Demetzos

  2. Theoretical and Physical Chemistry Institute, National Hellenic Research Foundation, 48 Vassileos Constantinou Avenue, 11635, Athens, Greece

    Natassa Pippa, Theodore Sentoukas & Stergios Pispas

  3. ELPEN Research -Experimental Centre, Athens, Greece

    Apostolos Papalois

  4. Department of Materials Science, University of Patras, Rion, Greece

    Nikolaos Bouropoulos

  5. Institute of Chemical Engineering and High Temperature Chemical Processes FORTH, Patras, Greece

    Nikolaos Bouropoulos

Authors
  1. Natassa Pippa
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  2. Theodore Sentoukas
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  3. Stergios Pispas
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  4. Costas Demetzos
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  5. Apostolos Papalois
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  6. Nikolaos Bouropoulos
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Correspondence to Natassa Pippa or Stergios Pispas.

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Pippa, N., Sentoukas, T., Pispas, S. et al. pH-responsive polymeric nanoassemblies encapsulated into alginate beads: morphological characterization and swelling studies. J Polym Res 25, 117 (2018). https://doi.org/10.1007/s10965-018-1519-1

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  • DOI: https://doi.org/10.1007/s10965-018-1519-1

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