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Alginate/carboxymethyl chitosan composite gel beads for oral drug delivery

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Abstract

This paper reports the synthesis of pH-sensitive gel beads derived from alginate (SA) and carboxymethyl chitosan (CMCS) for drug delivery. The composite SA/CMCS gel beads were prepared by dual ionic gelation: one ionic gelation between SA and Ca2+ and another one between CMCS and β-Sodium glycerophosphate (β-GP). The structure properties of hydrogel beads were characterized by SEM, IR and TG technique. The influence of the polymer composition and cross-linkers on the gel swelling property was investigated. When the concentration of CMCS and SA were 3 % and the volume ratio was 1:2, the swelling rate of gel beads crosslinked by β-GP and CaCl2 solution can increase up to 31.2 and the swelling time can reach 10.5 h. In the drug release study, bovine serum albumin (BSA) was chosen as model drugs. The results indicated that BSA released slowly from the gel beads at pH 1.2 and the release ratio was about 10 %. At pH 7.4, the amounts of BSA released increased significantly as compared to those released at pH 1.2 and the total release time was extended to 11 h. The composite gel system demonstrates sustained release profile and pH sensitivity, which can be considered as good candidates for oral drug delivery systems.

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Acknowledgments

The authors are grateful to the financial support from the National Natural Science Foundation of China (No.81401510), the Modernization Engineering Technology Research Center of Ethnic Minority Medicine of Hubei province (2015ZY001) and the academic team of South-central University for Nationalities (CZW15017).

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Authors and Affiliations

  1. College of Pharmacy, South-Central University for Nationalities, Wuhan, 430074, People’s Republic of China

    Yan Hu, Jing Peng, Lei Ke, Dan Zhao, Haiyan Zhao & Xincai Xiao

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  1. Yan Hu
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  2. Jing Peng
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  3. Lei Ke
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  4. Dan Zhao
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  5. Haiyan Zhao
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  6. Xincai Xiao
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Correspondence to Yan Hu or Xincai Xiao.

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Hu, Y., Peng, J., Ke, L. et al. Alginate/carboxymethyl chitosan composite gel beads for oral drug delivery. J Polym Res 23, 129 (2016). https://doi.org/10.1007/s10965-016-1022-5

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  • DOI: https://doi.org/10.1007/s10965-016-1022-5

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