Abstract
In this paper new pH sensitive nanocomposite beads were prepared by the combination of layered double hydroxides (LDH) and carboxymethyl cellulose (CMC). Ibuprofen (IBU), as a model drug, was intercalated between LDH layers through the co-precipitation method. The synthesized LDH-IBU nanohybrids and nanocomposites beads were characterized using FTIR, XRD, and SEM. In vitro tests of drug delivery in conditions simulating the gastrointestinal tract were carried out to prove the effectiveness of this novel type of nanocomposite beads as a controlled drug delivery system (DDS). The drug release tests revealed a better protection against stomach pH and a controlled liberation in the intestinal tract conditions for new nanocomposite beads.
Similar content being viewed by others
References
Sastry SV, Nyshadham JR, Fix JA (2000) Recent technological advances in oral drug delivery–a review. Pharm Sci Technol Today 3:138–145
Ganta S, Devalapally H, Shahiwala A, Amiji M (2008) A review of stimuli-responsive nanocarriers for drug and gene delivery. J Control Release 126:187–204
Huh KM, Kang HC, Lee YJ, Bae YH (2012) pH-sensitive polymers for drug delivery. Macromol Res 20:224–233
Hoare TR, Kohane DS (2008) Hydrogels in drug delivery: progress and challenges. Polymer 49:1993–2007
Qiu Y, Park K (2012) Environment-sensitive hydrogels for drug delivery. Adv Drug Deliver Rev 64:49–60
Jagur-Grodzinski J (2010) Polymeric gels and hydrogels for biomedical and pharmaceutical applications. Polym Adv Technol 21:27–47
Soppimath KS, Aminabhavi TM, Kulkarni AR, Rudzinski WE (2001) Biodegradable polymeric nanoparticles as drug delivery devices. J Control Release 70:1–20
Kumari A, Yadav SK, Yadav SC (2010) Biodegradable polymeric nanoparticles based drug delivery systems. Colloid Surface B 75:1–18
Malafaya PB, Elvira C, Gallardo A, San Roman J, Reis RL (2001) Porous starch-based drug delivery systems processed by a microwave route. J Biomater Sci Polym Ed 12:1227–1241
Bernkop-Schnürch A, Dünnhaupt S (2012) Chitosan-based drug delivery systems. Eur J Pharm Biopharm 81:463–469
Huang X, Xiao Y, Lang M (2012) Micelles/sodium-alginate composite gel beads: a new matrix for oral drug delivery of indomethacin. Carbohydr Polym 87:790–798
Bhattacharya SS, Shukla S, Banerjee S, Chowdhury P, Chakraborty P, Ghosh A (2013) Tailored IPN hydrogel bead of sodium carboxymethyl cellulose and sodium carboxymethyl xanthan gum for controlled delivery of diclofenac sodium. Polym Plast Technol 52:795–805
Rao KM, Mallikarjuna B, Rao KK, Prabhakar MN, Rao KC, Subha MCS (2012) Preparation and characterization of pH sensitive poly (vinyl alcohol)/sodium carboxymethyl cellulose IPN microspheres for in vitro release studies of an anti-cancer drug. Polym Bull 68:1905–1919
Wang S, Zhang Q, Tan B, Liu L, Shi L (2011) pH-Sensitive poly (Vinyl Alcohol)/sodium carboxymethylcellulose hydrogel beads for drug delivery. J Macromol Sci B 50:2307–2317
Boppana R, Kulkarni RV, Mutalik SS, Setty CM, Sa B (2010) Interpenetrating network hydrogel beads of carboxymethylcellulose and egg albumin for controlled release of lipid lowering drug. J Microencapsul 27:337–344
Yang XH, Zhu WL (2007) Viscosity properties of sodium carboxymethylcellulose solutions. Cellulose 14:409
Heinze T, Liebert T, Klüfers P, Meister F (1999) Carboxymethylation of cellulose in unconventional media. Cellulose 6:153
Stigsson V, Kloow G, Germgard U (2006) The influence of the solvent system used during manufacturing of CMC. Cellulose 13:705
Wang J, Somasundaran P (2005) Adsorption and conformation of carboxymethyl cellulose at solid–liquid interfaces using spectroscopic, AFM and allied techniques. J Colloid Interface Sci 291:75
Aguzzi C, Cerezo P, Viseras C, Caramella C (2007) Use of clays as drug delivery systems: possibilities and limitations. Appl Clay Sci 36:22–36
Viseras C, Cerezo P, Sanchez R, Salcedo I, Aguzzi C (2010) Current challenges in clay minerals for drug delivery. Appl Clay Sci 48:291–295
Oh JM, Biswick TT, Choy JH (2009) Layered nanomaterials for green materials. J Mater Chem 19:2553–2563
Del Hoyo C (2007) Layered double hydroxides and human health: an overview. Appl Clay Sci 36:103–121
Choy JH, Choi SJ, Oh JM, Park T (2007) Clay minerals and layered double hydroxides for novel biological applications. Appl Clay Sci 36:122–132
Williams GR, O'Hare D (2006) Towards understanding, control and application of layered double hydroxide chemistry. J Mater Chem 16:3065–3074
Darder M, Aranda P, Ruiz-Hitzky E (2007) Bionanocomposites: a new concept of ecological, bioinspired, and functional hybrid materials. Adv Mater 19:1309
Ruiz-Hitzky E, Darder M, Aranda P, Ariga K (2010) Advances in biomimetic and nanostructured biohybrid materials. Adv Mater 22:323
Wang Q, O'Hare D (2012) Recent advances in the synthesis and application of Layered Double Hydroxide (LDH) nanosheets. Chem Rev 112:4124
Yadollahi M, Namazi H (2013) Synthesis and characterization of carboxymethyl cellulose/layered double hydroxide nanocomposites. J Nanopart Res 15:1–9
Aisawa S, Sasaki S, Takahashi S, Hirahara H, Nakayama H, Narita E (2006) Intercalation of amino acids and oligopeptides into Zn–Al layered double hydroxide by coprecipitation reaction. J Phys Chem Solids 67:920–925
Lu X, Meng L, Li H, Du N, Zhang R, Hou W (2012) Facile fabrication of ibuprofen-LDH nanohybrids via a delamination/reassembling process. Mater Res Bull 48:1512–1517
Carlino S (1997) The intercalation of carboxylic acids into layered double hydroxides: a critical evaluation and review of the different methods. Solid State Ion 98:73–84
Rossi C, Schoubben A, Ricci M, Perioli L, Ambrogi V, Latterini L, Aloisi GG, Rossi A (2005) Intercalation of the radical scavenger ferulic acid in hydrotalcite-like anionic clays. Int J Pharm 295:47–55
Gasser MS (2009) Inorganic layered double hydroxides as ascorbic acid (vitamin c) delivery system—Intercalation and their controlled release properties. Colloid Surface B 73:103–109
Rogez G, Massobrio C, Rabu P, Drillon M (2011) Layered hydroxide hybrid nanostructures: a route to multifunctionality. Chem Soc Rev 40:1031–1058
Kuang Y, Zhao L, Zhang S, Zhang F, Dong M, Xu S (2010) Morphologies, preparations and applications of layered double hydroxide micro-/nanostructures. Materials 3:5220–5235
Costantino U, Ambrogi V, Nocchetti M, Perioli L (2008) Hydrotalcite-like compounds: versatile layered hosts of molecular anions with biological activity. Microporous Mesoporous Mater 107:149–160
Alcantara ACS, Aranda P, Darder M, Ruiz-Hitzky E (2010) Bionanocomposites based on alginate–zein/layered double hydroxide materials as drug delivery systems. J Mater Chem 20:9495–9504
Zhang JP, Wang Q, Xie XL, Li X, Wang AQ (2010) Preparation and swelling properties of pH‐sensitive sodium alginate/layered double hydroxides hybrid beads for controlled release of diclofenac sodium. J Biomed Mater Res B 92:205–214
Mahkam M, Davatgar M, Rezvani Z, Nejati K (2013) Preparation of pH-Sensitive polymers/layered double hydroxide hybrid beads for controlled release of insulin. Int J Polym Mater 62:57–60
Ambrogi V, Perioli L, Ricci M, Pulcini L, Nocchetti M, Giovagnoli S, Rossi C (2008) Eudragit® and hydrotalcite-like anionic clay composite system for diclofenac colonic delivery. Micropor Mesopor Mat 115:405–415
Mohamadnia Z, Zohuriaan-Mehr MJ, Kabiri K, Razavi-Nouri M (2008) Tragacanth gum-graft-polyacrylonitrile: synthesis, characterization and hydrolysis. J Polym Res 15:173
Olanrewaju J, Newalkar BL, Mancino C, Komarneni S (2000) Simplified synthesis of nitrate form of layered double hydroxide. Mater Lett 45:307–310
Ambrogi V, Fardella G, Grandolini G, Perioli L (2001) Intercalation compounds of hydrotalcite-like anionic clays with antiinflammatory agents—I. Intercalation and in vitro release of ibuprofen. Int J Pharmaceut 220:23–32
Evans DG, Slade RCT (2005) Structural aspects of layered double hydroxides. Struct Bond 119:1
Li J, Lu J, Li Y (2009) Carboxylmethylcellulose/bentonite composite gels: water sorption behavior and controlled release of herbicide. J Appl Polym Sci 112:261
Nie H, Liu M, Zhan F, Guo M (2004) Factors on the preparation of carboxymethylcellulose hydrogel and its degradation behavior in soil. Carbohydr Polym 58:185
Yadollahi M, Namazi H, Barkhordari S (2014) Preparation and properties of carboxymethyl cellulose/layered double hydroxide bionanocomposite films. Carbohyd Polym, accepted manuscript available online
Kim MS, Park SJ, Gu BK, Kim CH (2012) Ionically crosslinked alginate–carboxymethyl cellulose beads for the delivery of protein therapeutics. Appl Surf Sci 262:28
Angadi SC, Manjeshwar LS, Aminabhavi TM (2012) Novel composite blend microbeads of sodium alginate coated with chitosan for controlled release of amoxicillin. Int J Biol Macromol 51:45
Kim B, Peppas NA (2002) Complexation phenomena in pH-responsive copolymer networks with pendent saccharides. Macromolecules 35:9545
Zakhireh S, Mahkam M, Yadollahi M, Jafarirad S (2014) Investigation of pH-sensitive galactopyranoside glycol hydrogels as effective vehicles for oral drug delivery. J Polym Res 21:1
Ambrogi V, Fardella G, Grandolini G, Perioli L (2001) Intercalation compounds of hydrotalcite-like anionic clays with antiinflammatory agents—I. Intercalation and in vitro release of ibuprofen. Int J Pharmaceut 220:23
Khan AI, Lei L, Norquist AJ, O’Hare D (2001) Intercalation and controlled release of pharmaceutically active compounds from a layered double hydroxide. Chem Commun 22:2342
Li B, He J, Evans DG, Duan X (2004) Enteric-coated layered double hydroxides as a controlled release drug delivery system. Int J Pharmaceut 287:89
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Barkhordari, S., Yadollahi, M. & Namazi, H. pH sensitive nanocomposite hydrogel beads based on carboxymethyl cellulose/layered double hydroxide as drug delivery systems. J Polym Res 21, 454 (2014). https://doi.org/10.1007/s10965-014-0454-z
Received:
Accepted:
Published:
DOI: https://doi.org/10.1007/s10965-014-0454-z