Abstract
A sustained drug delivery system is developed by using nonionic polymer to formulate drug release rate from silica capsules. To serve this purpose, silica capsules filled with poly(ethylene glycol) (PEG) were incorporated with a veterinary antibiotic drug enrofloxacin (ENF); as a model hydrophobic drug by using a general and facile sol–gel route. The physicochemical properties of the prepared drug-loaded composites were investigated by scanning electron microscope (SEM), nitrogen adsorption, Fourier transform infrared spectroscopy and thermal analysis (TGA). The impact of the media’s ionic strength on the drug release was evaluated over a range of 0–0.4 M to simulate the gastrointestinal feed in two physiological pH conditions. Sodium chloride was applied for ionic concentration adjustment due to its ability to salt out polymers in the midrange of the lyotropic series. Simultaneously, the drug release kinetics was evaluated by fitting experimental data to common empirical (zero-order, first order and Higuchi) and semi-empirical (Ritger–Peppas and Sahlin–Peppas) models. The drug release kinetics from capsules revealed a non-Fickian diffusion and pure relaxation-controlled release. Of these models, Sahlin–Peppas equation best fit the release data of ENF. To determine the best model, non-linear regressions were carried out.
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References
Jimenez A, Zaikov GE (2009) Recent advances in research on biodegradable polymers and sustainable composites. Nova Science Publishers, New York
Aich N, Plazas-Tuttle J, Lead JR, Saleh NB (2014) Environ Chem 11(6):609–623
de Sousa A, Maria DA, de Sousa RG et al (2010) J Mater Sci 45:1478–1486
Catauro M, Papale F, Bollino F et al (2014) Mater Sci Eng C 40:253–259
Kokkarachedu V, Vimala K, Sakey R et al (2012) J Polym Environ 20:573–582
Ravindra S, Varaprasad K, Narayana RN et al (2011) J Polym Environ 19:413–418
Khan NU, Bharathi NP, Shreaz S et al (2011) J Polym Environ 19:607–614
Slowing II, Vivero-Escoto JL, Wu CW, Lin VSY (2008) Adv Drug Deliv Rev 60:1278–1288
Barbe BC, Bartlett J, Kong L et al (2004) Adv Mater 16:1959–1966
Chen Y, Wang YJ, Yang LM, Luo GS (2008) AIChE J 54:298–309
Trewyn BG, Slowing II, Giri S, Chen HT, Lin VSY (2007) Acc Chem Res 40:846–853
Persad CV, Swamy BY, Reddy CLN et al (2012) J Polym Environ 20:344–352
Vialpando M, Aerts A, Persoons J et al (2011) J Pharm Sci 100(8):3411–3420
Speybroeck MV, Barillaro V, Thi TD et al (2009) J Pharm Sci 98(8):2648–2658
Utech S, Boccaccini AR (2016) J Mater Sci 51:271–310
Catauro M, Renella RA, Papale F, Ciprioti SV (2016) Mater Sci Eng C 61:51–55
Kerkhofs S, Saidi F, Vandarvoort N et al (2015) J Mater Chem B 3:3054–3061
Haritova A, Lashev L, Pashov D (2003) Res Vet Sci 74:241–245
Nakagawa H, Keshikawa T, Matsumura M, Tsukamoto H (1991) Chem Pharm Bull 39:1837–1842
Baral SS, Das N, Ramulu TS, Sahoo SK et al (2009) J Hazard Mater 161:1427–1435
Friend DR (1992) J Microencapsul 9:469–480
Takahasi Y, Tsukuda T, Izum C et al (1988) Chem Pharm Bull 36:2708–2710
Alexander J, Fromtling RA, Bland JA et al (1991) J Med Chem 34(1):78–81
Suzuki S, Lim JK (1994) J Microencapsul 11:197–203
Kim EH, Choi HK (2004) Drug Deliv 11:365–370
Kumar GP, Phani AR, Prasad RGSV. et al (2014) Int J Pharm 471:146–152
Song M, Song J, Ning A et al (2010) Mater Sci Eng C 30:58–61
Ebadi A, Rafati AA (2015) J Mol Liq 209:239–245
Baral SS, Das N, Ramulu TS et al (2009) J Hazard Mater 161:1427–1435
Martinez YN, Pinuel L, Castro GR, Breccia JD (2012) Appl Biochem Biotechnol 167:1421–1429
Yang HS, Choi SY (1999) Thin Solid Films 348:69–73
Brinker CJ, Scherer GW (1990) Structural changes during heating: amorphous systems. Academic Press, New York, pp 547–615
Fonseca LC, Paulab AJ, Martinezc DST, Alves OL (2016) New J Chem 40:8060–8067
Dressman JB, Reppas C (2000) Eur J Pharm Sci 11:S73–S80
Johnson JL, Holinej J, Williams MD (1993) Int J Pharm 90:151–159
Lindahl WD, Ungell AL, Knutson L, Lennernas H (1997) Pharm Res 14:497–502
Colombo P, Catellani PL, Peppas NA et al (1992) Int J Pharm 88:99–109
Bravo SA, Lamas MC, Salomon CJ (2002) J Pharm Pharm Sci 5:213–219
Higuchi T (1963) J Pharm Sci 52:1145–1149
Baker RW, Lonsdale HS (1974) Controlled release of biologically active agents. Plenum Press, New York
Hixson AW, Crowell JH (1931) Ind Eng Chem 23:923–931
Ritger PL, Peppas NA (1987) J Control Release 5:23–36
Peppas NA, Sahlin JJ (1989) Int J Pharm 57:169–172
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The authors gratefully acknowledge Bu-Ali Sina University for their financial support.
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Ebadi, A., Rafati, A.A. Development of Novel Biodegradable Enrofloxacin–Silica Composite for In Vitro Drug Release Kinetic Studies. J Polym Environ 26, 3404–3411 (2018). https://doi.org/10.1007/s10924-018-1228-1
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DOI: https://doi.org/10.1007/s10924-018-1228-1