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Synthesis, Characterization, Crystal Structure and Antimicrobial Evaluation of a Novel –M–X–M–X– Type Infinite Chain 1D Cu(II) Complex with Eflornithine Hydrochloride Hydrate as Ligand

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Abstract

A novel –M–X–M–X– type infinite chain 1D copper(II) complex of Eflornithine, Dichloro-[2-amino-5-ammonio-2-(difluoromethyl)pentanoate]copper(II) hydrate, [Cu(C6H12F2N2O2)Cl2]·H2O 1 has been synthesized and characterized by elemental analysis, spectroscopic techniques (UV/Vis and FT-IR), TGA and X-ray diffraction. Single-crystal X-ray diffraction analysis of the complex 1 showed the structure to be monoclinic with space group Cc, a = 13.1295(15) Å, b = 12.1859(14) Å, c = 8.1927(9) Å, β = 118.359(3) Å, V = 1153.5(2) Å3, Z = 4. The complex exhibits a quadratic planar coordination of the Cu-atom. The Cu(II) centre is coordinated by two chloride atoms, an oxygen atom of the carboxyl- and a nitrogen atom of the amino-group, respectively, forming a quadratic planar geometry. The terminal amino group of the ligand is protonated to form NH3 + while the carboxylic moiety is deprotonated to form Zwitterionic eflornithine ligand, with the coordination of the metal at the nitrogen atom of the second amino group. The compound has –M–X–M–X– infinite 1D chain polymeric structure. Two neigbouring Cu(EFL)Cl chain units are bridged by an Cl− ion, forming a –Cu–Cl–Cu–Cl– linear chain structure along C-axis. The antibacterial activities of the complex on Escherichia coli (E. coli), Staphylococcus aureus (S. aureus) and Pseudomonas aeruginosa (P. aeruginosa) were investigated and found to be active at higher concentration than the parent ligand.

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Acknowledgments

We are grateful for the support from the World Bank Science and Technology Education Post-Basic Project (STEP-B), Department of Chemistry University of Ilorin and Dr. Michael Wörle for help with the crystal structure determination during the Zurich School of Crystallography 2013 at the University of Zurich, Institute of Organic Chemistry, Winterthurersthrasse 190 CH-8057, Zurich.

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Authors and Affiliations

  1. Department of Chemistry, P.M.B. 1515, University of Ilorin, Ilorin, Kwara State, Nigeria

    Joshua A. Obaleye, Adedibu C. Tella, Wahab A. Osunniran & Nzikahyel Simon

  2. Department of Chemistry, University of Uyo, Uyo, Akwa Ibom State, Nigeria

    Nzikahyel Simon

  3. Department of Microbiology, P.M.B. 1515, University of Ilorin, Ilorin, Kwara State, Nigeria

    Patricia F. Omojasola

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  1. Joshua A. Obaleye
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  3. Wahab A. Osunniran
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Correspondence to Joshua A. Obaleye.

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Obaleye, J.A., Tella, A.C., Osunniran, W.A. et al. Synthesis, Characterization, Crystal Structure and Antimicrobial Evaluation of a Novel –M–X–M–X– Type Infinite Chain 1D Cu(II) Complex with Eflornithine Hydrochloride Hydrate as Ligand. J Inorg Organomet Polym 24, 827–835 (2014). https://doi.org/10.1007/s10904-014-0052-x

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