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Biomimetic Cerium Oxide Loaded Gelatin PCL Nanosystems for Wound Dressing on Cutaneous Care Management of Multidrug-Resistant Bacterial Wound Healing

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Abstract

Skin wound healing involves a coordinated cellular response to achieve complete reepithelialization. Elevated levels of reactive oxygen species (ROS) in the wound environment often pose a hindrance in wound healing resulting in impaired wound healing process. Herein, cerium oxide nanoparticles (CeNPs) matrices like nanofibers have also been explored for enhancing wound healing. In this work, we have established the fabrication of CeNPs functionalized gelatin polycaprolactone (PCL) nanofibers (PCLNF) and CeNPs laden with PCL nanofiber (PCLNPNF) matrices by the electrospun methods. The bioactive composition PCLNPNF maintained the fiber morphological behaviour for up to 15 days. Further, the PCLNPNF matrices enhanced the cell proliferation against the NIH-3T3 cell lines established by Alamar blue assay. Furthermore, the PCLNPNF matrices scavenged ROS property examined with DCFH-DA intensity of the fluorescence microscopy. The antibacterial property of the PCLNPNF shows the remarkable activity against the gram-positive (S. aureus), and gram-negative (P. aeruginosa). Additionally, the in vivo bacterial removals and invented wound injuries examined development were definite through the MRSA-infects mice model. Taking to the advantages of this work, the newly fabricated PCLNPNF is a promising antibiotic alternative to battle the various bacterial infections in future.

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Author notes

  1. Yi Fei and Qiong Huang contributed equally to this work

Authors and Affiliations

  1. Wound Stoma Clinic, Affiliated Cixi Hospital, Wenzhou Medical University, No.999, Second South Ring East Road, Cixi, 315300, China

    Yi Fei

  2. Operation Room, Hangzhou First People’s Hospital Affiliated to Zhejiang University, Hangzhou, 310006, China

    Qiong Huang

  3. Department of Nursing Care, Affiliated Cixi Hospital, Wenzhou Medical University, Ningbo, 315300, China

    Zheqing Hu, Xunv Yang & Baifen Yang

  4. Department of Interventional Vascular Surgery, The Fourth Affiliated Hospital of Harbin Medical University, No. 37, Yiyuan Street, Harbin, 150001, China

    Shuang Liu

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  1. Yi Fei
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Fei, Y., Huang, Q., Hu, Z. et al. Biomimetic Cerium Oxide Loaded Gelatin PCL Nanosystems for Wound Dressing on Cutaneous Care Management of Multidrug-Resistant Bacterial Wound Healing. J Clust Sci 32, 1289–1298 (2021). https://doi.org/10.1007/s10876-020-01866-9

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