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Antidiabetic and Antioxidant Activity of Green Synthesized Starch Nanoparticles: An In Vitro Study

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A Correction to this article was published on 21 January 2020

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Abstract

This study was aimed to assess the antidiabetic and antioxidant activity of starch nanoparticles (StNPs) synthesized by green synthesis through in vitro model. Several organic solvents were used for the extraction of active compounds from Gymnema sylvestre. The methanolic extract was used for the synthesis of StNPs from dried potato starch. The characterization studies such as GC–MS, FT-IR, SEM, EDS and XRD were performed to analyze the sample. The StNPs were found to be ellipsoidal in nature with the average particle size of 19.8 nm. The StNPs showed highest DPPH radical scavenging activity with 74.41 ± 0.54% at 100 µg/mL concentration. Besides, the IC50 values were found to be 66.69 µg/mL and 61.99 µg/mL for the StNPs and standard (ascorbic acid), respectively. The StNPs showed the highest metal ion chelating activity of 66.71 ± 0.34% at a concentration of 100 µg/mL. The highest reducing power of StNPs was found to be 0.385 ± 0.002 at 100 µg/mL. Moreover, in vitro antidiabetic activity was studied using alpha-amylase inhibition assay and the highest inhibition activity of StNPs was 58.56 ± 0.44% at a concentration of 100 µg/mL. The present study provided preliminary evidence indicated that the StNPs synthesized using methanolic extract of G. sylvestre had potential activity against diabetes.

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  • 21 January 2020

    In the original version of the article the acknowledgement section was unfortunately missed. The acknowledgement is published in this erratum article.

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Authors and Affiliations

  1. Department of Biotechnology, K.S.Rangasamy College of Technology, Namakkal (District), Tiruchengode, Tamil Nadu, 637 215, India

    Vishnupriyan Varadharaj & Rajeswari Sakthivel

  2. Department of Biotechnology, Saveetha School of Engineering, Saveetha Institute of Medical and Technical Sciences, Saveetha Nagar, Chennai, Tamil Nadu, 602105, India

    Arulvel Ramaswamy & Ramasamy Subbaiya

  3. Department of Pharmaceutical Biotechnology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Hamed Barabadi

  4. Department of Food Science and Biotechnology, Sejong University, Seoul, Republic of Korea

    Murugesan Chandrasekaran

  5. Department of Medical Microbiology and Immunology, Division of Biomedical Science, School of Medicine, College of Health Sciences, Mekelle University, Mekelle, Ethiopia

    Muthupandian Saravanan

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  1. Vishnupriyan Varadharaj
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  2. Arulvel Ramaswamy
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  3. Rajeswari Sakthivel
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  4. Ramasamy Subbaiya
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Correspondence to Arulvel Ramaswamy or Muthupandian Saravanan.

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Varadharaj, V., Ramaswamy, A., Sakthivel, R. et al. Antidiabetic and Antioxidant Activity of Green Synthesized Starch Nanoparticles: An In Vitro Study. J Clust Sci 31, 1257–1266 (2020). https://doi.org/10.1007/s10876-019-01732-3

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  • DOI: https://doi.org/10.1007/s10876-019-01732-3

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