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Antineoplastic Biogenic Silver Nanomaterials to Combat Cervical Cancer: A Novel Approach in Cancer Therapeutics

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Abstract

Nanomedicine is a rapidly growing and promising field to combat cancer. This study was aimed to systematically review the original published articles to evaluate the efficacy of biologically synthesized silver nanoparticles (AgNPs) against cervical cancer cells through in vitro investigations. The articles were selected through the online databases, including Cochrane, Embase, Scopus, PubMed, Science Direct, ProQuest, and Web of Science for the articles published up to 31 August 2019. Sixty-five articles were found eligible to enter into our study. Our finding revealed that a vast 92.3% of articles stated the significant cytotoxicity of biogenic AgNPs against cervical cancer cells, while 7.7% of articles represented no cytotoxicity against cervical cancer cells. The proposed molecular mechanisms of anticancer activity of biogenic AgNPs against cervical cancer cells included the release of silver cations from AgNPs in the cell culture medium, generation of intracellular Reactive Oxygen Species (ROS), induction of apoptosis pathways, and DNA damage. This study provided significant preliminary evidence from the anticancer potential of biogenic AgNPs against cervical cancer cells. Future molecular studies will elucidate the exact molecular mechanisms of biogenic AgNPs-induced cytotoxicity in cervical cancer cells.

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References

  1. C. Vora and S. Gupta (2019). ESMO Open3, e000462.

    Article  PubMed  PubMed Central  Google Scholar 

  2. R. L. Siegel, K. D. Miller, and A. Jemal (2019). CA Cancer J. Clin.69, 7.

    Article  PubMed  Google Scholar 

  3. Z. Momenimovahed and H. Salehiniya (2017). Biomed. Res. Ther.4, 1795.

    Article  Google Scholar 

  4. L. E. Minion, J. Bai, B. J. Monk, L. Robin Keller, E. N. Ramez, G. K. Forde, J. K. Chan, and K. S. Tewari (2015). Gynecol. Oncol.137, 490.

    Article  CAS  PubMed  Google Scholar 

  5. J. Chen, W. Gu, L. Yang, C. Chen, R. Shao, K. Xu, and Z. P. Xu (2015). Rev. Med. Virol.25, (Suppl 1), 72.

    Article  PubMed  CAS  Google Scholar 

  6. N. Casagrande, M. De Paoli, M. Celegato, C. Borghese, M. Mongiat, A. Colombatti, and D. Aldinucci (2013). Gynecol. Oncol.131, 744.

    Article  CAS  PubMed  Google Scholar 

  7. C. N. Sreekanth, S. V. Bava, E. Sreekumar, and R. J. Anto (2011). Oncogene30, 3139.

    Article  CAS  PubMed  Google Scholar 

  8. C. Jin, L. Bai, H. Wu, W. Song, G. Guo, and K. Dou (2009). Pharm. Res.26, 1776.

    Article  CAS  PubMed  Google Scholar 

  9. S. Palantavida, N. V. Guz, C. D. Woodworth, and I. Sokolov (2013). Nanomedicine9, 1255.

    Article  CAS  PubMed  Google Scholar 

  10. H. Barabadi, F. Kobarfard, and H. Vahidi (2018). Iran J. Pharm Res.17, 87.

    CAS  PubMed  PubMed Central  Google Scholar 

  11. H. Barabadi, S. Honary, P. Ebrahimi, A. Alizadeh, F. Naghibi, and M. Saravanan (2019). Inorg. Nano-Met. Chem.49, 33.

    Article  CAS  Google Scholar 

  12. H. Barabadi, M. A. Mahjoub, B. Tajani, A. Ahmadi, Y. Junejo, and M. Saravanan (2019). J. Clust. Sci.30, 259.

    Article  CAS  Google Scholar 

  13. M. Ovais, A. T. Khalil, A. Raza, M. A. Khan, I. Ahmad, N. U. Islam, M. Saravanan, M. F. Ubaid, M. Ali, and Z. K. Shinwari (2016). Nanomedicine11, 3157.

    Article  CAS  PubMed  Google Scholar 

  14. M. J. Ahmed, G. Murtaza, F. Rashid, and J. Iqbal (2019). Drug Dev. Ind. Pharm.45, 1682–1694.

    Article  CAS  PubMed  Google Scholar 

  15. M. Hamelian, M. M. Zangeneh, A. Amisama, K. Varmira, and H. Veisi (2018). Appl. Organomet. Chem.32, e4458.

    Article  CAS  Google Scholar 

  16. K. D. Datkhile, P. P. Durgavale, and M. N. Patil (2017). J. Bionanosci.11, 416.

    Article  CAS  Google Scholar 

  17. D. Moher, A. Liberati, J. Tetzlaff, and D. G. Altman (2009). PLoS Med.6, e1000097.

    Article  PubMed  PubMed Central  Google Scholar 

  18. M. M. Zangeneh, S. Bovandi, S. Gharehyakheh, A. Zangeneh, and P. Irani (2019). Appl. Organomet. Chem.33, e4961.

    Google Scholar 

  19. R. Yadav, H. Saini, D. Kumar, S. Pasi, and V. Agrawal (2019). Mater. Sci. Eng. C.104, 109984.

    Article  CAS  Google Scholar 

  20. D. Tripathi, A. Modi, G. Narayan, and S. P. Rai (2019). Mater. Sci. Eng. C100, 152.

    Article  CAS  Google Scholar 

  21. H. Saini, R. Yadav, D. Kumar, G. Kumar, and V. Agrawal (2019). J. Clust. Sci.. https://doi.org/10.1007/s10876-019-01630-8.

    Article  Google Scholar 

  22. L. K. Ruddaraju, P. N. V. K. Pallela, S. V. N. Pammi, V. S. Padavala, and V. R. M. Kolapalli (2019). Mat. Sci. Semicond. Proc.100, 301.

    Article  CAS  Google Scholar 

  23. A. S. Phirange and S. G. Sabharwal (2019). Indian J. Biotechnol.18, 52.

    CAS  Google Scholar 

  24. E. E. Elemike, D. C. Onwudiwe, N. Nundkumar, M. Singh, and O. Iyekowa (2019). Mater. Lett.243, 148.

    Article  CAS  Google Scholar 

  25. S. Zada, A. Ahmad, S. Khan, X. Yu, K. Chang, A. Iqbal, A. Ahmad, S. Ullah, M. Raza, A. Khan, S. Ahmad, and P. Fu (2018). Artif. Cells Nanomed. Biotechnol.46, S471.

    Article  CAS  PubMed  Google Scholar 

  26. M. Wypij, J. Czarnecka, M. Świecimska, H. Dahm, M. Rai, and P. Golinska (2018). World J. Microbiol. Biotechnol.34, 23.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  27. T. V. M. Sreekanth, P. C. Nagajyothi, P. Muthuraman, G. Enkhtaivan, S. V. P. Vattikuti, C. O. Tettey, D. H. Kim, J. Shim, and K. Yoo (2018). J. Photochem. Photobiol. B.188, 6.

    Article  CAS  PubMed  Google Scholar 

  28. R. E. Shafek, H. N. Michael, A. Z. Sayed, A. G. Ibrahim, and A. M. Al-Sayed (2018). Egypt. J. Chem.61, 237.

    Google Scholar 

  29. S. Sarkar and V. Kotteeswaran (2018). Adv. Nat. Sci.9, 025014.

    Google Scholar 

  30. L. Salazar, M. J. V. Lopez, M. Grijalva, L. Castillo, and A. Maldonado (2018). J. Nanotechnol.. https://doi.org/10.1155/2018/9689131.

    Article  Google Scholar 

  31. R. R. Palem, S. D. Ganesh, Z. Kronekova, M. Slavikova, N. Saha, and P. Saha (2018). Bull. Mater. Sci.41, 55.

    Article  CAS  Google Scholar 

  32. P. Moteriya and S. Chanda (2018). J. Genet. Eng. Biotechnol.16, 105.

    Article  PubMed  PubMed Central  Google Scholar 

  33. A. J. Kora and R. B. Sashidhar (2018). Arab. J. Chem.11, 313.

    Article  CAS  Google Scholar 

  34. K. Jadhav, S. Deore, D. Dhamecha, R. Hr, S. Jagwani, S. Jalalpure, and R. Bohara (2018). ACS Biomater. Sci. Eng.4, 892.

    Article  CAS  Google Scholar 

  35. D. Arumai Selvan, D. Mahendiran, R. Senthil Kumar, and A. Kalilur Rahiman (2018). J. Photochem. Photobiol. B.180, 243.

    Article  CAS  PubMed  Google Scholar 

  36. M. Anjugam, B. Vaseehara, A. Iswarya, M. Divya, N. M. Prabhu, and K. Sankaranarayanan (2018). Microb. Pathog.115, 31.

    Article  CAS  PubMed  Google Scholar 

  37. E. S. Al-Sheddi, N. N. Farshori, M. M. Al-Oqail, S. M. Al-Massarani, Q. Saquib, R. Wahab, J. Musarrat, A. A. Al-Khedhairy, and M. A. Siddiqui (2018). Bioinorg. Chem. Appl.. https://doi.org/10.1155/2018/9390784.

    Article  PubMed  PubMed Central  Google Scholar 

  38. S. Yeasmin, H. K. Datta, S. Chaudhuri, D. Malik, and A. Bandyopadhyay (2017). J. Mol. Liq.242, 757.

    Article  CAS  Google Scholar 

  39. P. Venkatachalam, T. Kayalvizhi, J. Udayabanu, G. Benelli, and N. Geetha (2017). J. Clust. Sci.28, 607.

    Article  CAS  Google Scholar 

  40. H. Singh, J. Du, and T. H. Yi (2017). Artif. Cells Nanomed. Biotechnol.45, 1310.

    Article  CAS  PubMed  Google Scholar 

  41. T. Rasheed, M. Bilal, H. M. N. Iqbal, and C. Li (2017). Colloids Surf. B.158, 408.

    Article  CAS  Google Scholar 

  42. C. Rajkuberan, S. Prabukumar, G. Sathishkumar, A. Wilson, K. Ravindran, and S. Sivaramakrishnan (2017). J. Saudi Chem. Soc.21, 911.

    Article  CAS  Google Scholar 

  43. P. Moteriya and S. Chanda (2017). Artif. Cells Nanomed. Biotechnol.45, 1556.

    Article  CAS  PubMed  Google Scholar 

  44. A. Maji, M. Beg, A. K. Mandal, S. Das, P. K. Jha, A. Kumar, S. Sarwar, M. Hossain, and P. Chakrabarti (2017). J. Mol. Struct.1141, 584.

    Article  CAS  Google Scholar 

  45. A. H. A. Kelkawi, A. AbbasiKajani, and A.-K. Bordbar (2017). IET Nanobiotechnol.11, 370.

    Article  PubMed  Google Scholar 

  46. P. P. Dutta, M. Bordoloi, K. Gogoi, S. Roy, B. Narzary, D. R. Bhattacharyya, P. K. Mohapatra, and B. Mazumder (2017). Biomed. Pharmacother.91, 567.

    Article  CAS  PubMed  Google Scholar 

  47. J. Venkatesan, S. K. Kim, and M. S. Shim (2016). Nanomaterials6, 235.

    Article  PubMed Central  CAS  Google Scholar 

  48. T. V. M. Sreekanth, M. Pandurangan, D. H. Kim, and Y. R. Lee (2016). J. Clust. Sci.27, 671.

    Article  CAS  Google Scholar 

  49. T. V. M. Sreekanth, M. Pandurangan, M. J. Jung, Y. R. Lee, and I. Y. Eom (2016). Res. Chem. Intermed.42, 5665.

    Article  CAS  Google Scholar 

  50. D. Rathod, P. Golinska, M. Wypij, H. Dahm, and M. Rai (2016). Med. Microbiol. Immunol.205, 435.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  51. K. Prabakaran, C. Ragavendran, and D. Natarajan (2016). RSC Adv.6, 44972.

    Article  CAS  Google Scholar 

  52. S. Panja, I. Chaudhuri, K. Khanra, and N. Bhattacharyya (2016). Asian Pac. J. Trop. Dis.6, 549.

    Article  Google Scholar 

  53. G. Mahendran and B. D. Ranjitha Kumari (2016). Food Sci. Hum. Wellness.5, 207.

    Article  Google Scholar 

  54. V. Maharani, A. Sundaramanickam, and T. Balasubramanian (2016). Enzyme Microb. Technol.95, 146.

    Article  CAS  PubMed  Google Scholar 

  55. M. Gorbe, R. Bhat, E. Aznar, F. Sancenon, M. D. Marcos, F. J. Herraiz, J. Prohens, A. Venkataraman, and R. Martinez-Manez (2016). Materials9, 325.

    Article  PubMed Central  CAS  Google Scholar 

  56. J. Du, H. Singh, and T.-H. Yi (2016). Bioprocess Biosyst. Eng.39, 1923.

    Article  CAS  PubMed  Google Scholar 

  57. H. M. Abd-Elnaby, G. M. Abo-Elala, U. M. Abdel-Raouf, and M. M. Hamed (2016). Egypt. J. Aquat. Res.42, 301.

    Article  Google Scholar 

  58. C. Rajkuberan, K. Sudha, G. Sathishkumar, and S. Sivaramakrishnan (2015). Spectrochim. Acta A.136, 924.

    Article  CAS  Google Scholar 

  59. R. Nalavothula, J. Alwala, V. B. Nagati, and P. R. Manthurpadigya (2015). Int. J. ChemTech Res.7, 2460.

    CAS  Google Scholar 

  60. D. K. Maravi, A. K. Sahoo, U. Goswami, D. S. Prasad, L. Sahoo, and S. S. Ghosh (2015). Int. J. Pharm. Bio Sci.6, P482.

    Google Scholar 

  61. K. Govindaraju, K. Krishnamoorthy, S. A. Alsagaby, G. Singaravelu, and M. Premanathan (2015). IET Nanobiotechnol.9, 325.

    Article  PubMed  Google Scholar 

  62. J. Christy, D. Dharaneya, V. Vinmathi, and S. J. P. Jacob (2015). Int. J. Pharm. Pharm. Sci.7, 192.

    CAS  Google Scholar 

  63. A. B. Chanthini, G. Balasubramani, R. Ramkumar, R. Sowmiya, M. D. Balakumaran, P. T. Kalaichelvan, and P. Perumal (2015). J. Photochem. Photobiol. B.153, 145.

    Article  CAS  PubMed  Google Scholar 

  64. M. D. Balakumaran, R. Ramachandran, and P. T. Kalaichelvan (2015). Microbiol. Res.178, 9.

    Article  CAS  PubMed  Google Scholar 

  65. R. Anju Varghese, P. Anandhi, R. Arunadevi, A. Boovisha, P. Sounthari, J. Saranya, K. Parameswari, and S. Chitra (2015). J. Pharm. Sci. Res.7, 266.

    Google Scholar 

  66. K. Vasanth, K. Ilango, R. MohanKumar, A. Agrawal, and G. P. Dubey (2014). Colloids Surf. B.117, 354.

    Article  CAS  Google Scholar 

  67. T. V. M. Sreekanth, S. Ravikumar, and I.-Y. Eom (2014). J. Photochem. Photobiol. B.141, 100.

    Article  CAS  PubMed  Google Scholar 

  68. V. Ramalingam, R. Rajaram, C. PremKumar, P. Santhanam, P. Dhinesh, S. Vinothkumar, and K. Kaleshkumar (2014). J. Basic Microbiol.54, 928.

    Article  CAS  PubMed  Google Scholar 

  69. P. Rajasekharreddy and P. U. Rani (2014). Mater. Sci. Eng. C39, 203.

    Article  CAS  Google Scholar 

  70. R. Nalvolthula, R. Merugu, and M. P. PratapRudra (2014). Int. J. ChemTech Res.7, 2374.

    Google Scholar 

  71. J. R. Nakkala, R. Mata, A. K. Gupta, and S. R. Sadras (2014). Eur. J. Med. Chem.85, 784.

    Article  CAS  PubMed  Google Scholar 

  72. A. K. Jha and K. Prasad (2014). Adv. Mater. Lett.5, 501.

    Article  CAS  Google Scholar 

  73. T. Y. Suman, S. R. Radhika Rajasree, A. Kanchana, and S. B. Elizabeth (2013). Colloids Surf. B.106, 74.

    Article  CAS  Google Scholar 

  74. T. Shanmugasundaram, M. Radhakrishnan, V. Gopikrishnan, R. Pazhanimurugan, and R. Balagurunathan (2013). Colloids Surf. B111, 680.

    Article  CAS  Google Scholar 

  75. P. Manivasagan, J. Venkatesan, K. Senthilkumar, K. Sivakumar, and S. K. Kim (2013). BioMed. Res. Int.. https://doi.org/10.1155/2013/287638.

    Article  PubMed  PubMed Central  Google Scholar 

  76. M. Jeyaraj, M. Rajesh, R. Arun, D. MubarakAli, G. Sathishkumar, G. Sivanandhan, G. K. Dev, M. Manickavasagam, K. Premkumar, N. Thajuddin, and A. Ganapathi (2013). Colloids Surf. B102, 708.

    Article  CAS  Google Scholar 

  77. S. Barua, R. Konwarh, S. S. Bhattacharya, P. Das, K. S. Devi, T. K. Maiti, M. Mandal, and N. Karak (2013). Colloids Surf. B105, 37.

    Article  CAS  Google Scholar 

  78. R. Sukirtha, K. M. Priyanka, J. J. Antony, S. Kamalakkannan, R. Thangam, P. Gunasekaran, M. Krishnan, and S. Achiraman (2012). Process Biochem.47, 273.

    Article  CAS  Google Scholar 

  79. C. Dipankar and S. Murugan (2012). Colloids Surf. B.98, 112.

    Article  CAS  Google Scholar 

  80. H. Barabadi, M. Najafi, H. Samadian, A. Azarnezhad, H. Vahidi, M. A. Mahjoub, M. Koohiyan, and A. Ahmadi (2019). Medicina55, 439.

    Article  PubMed Central  Google Scholar 

  81. S. Ahmed, M. Ahmad, B. L. Swami, and S. Ikram (2016). J. Adv. Res.7, 17.

    Article  CAS  PubMed  Google Scholar 

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Acknowledgements

This work was financially supported by Shahid Beheshti University of Medical Sciences, Tehran, Iran [Grant Number 20417].

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Authors and Affiliations

  1. Department of Pharmaceutical Biotechnology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Hamed Barabadi & Hossein Vahidi

  2. Golestan University of Medical Sciences, Food and Drug Administration, Gorgan, Iran

    Kaveh Damavandi Kamali

  3. Student Research Committee, School of Medicine, Gonabad University of Medical Sciences, Gonabad, Iran

    Masoumeh Rashedi

  4. Department of Medical Microbiology and Immunology, Division of Biomedical Sciences, School of Medicine, College of Health Sciences, Mekelle University, 1871, Mekelle, Ethiopia

    Muthupandian Saravanan

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  1. Hamed Barabadi
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Barabadi, H., Vahidi, H., Damavandi Kamali, K. et al. Antineoplastic Biogenic Silver Nanomaterials to Combat Cervical Cancer: A Novel Approach in Cancer Therapeutics. J Clust Sci 31, 659–672 (2020). https://doi.org/10.1007/s10876-019-01697-3

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