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Effect of Formulation and Processing Variables on Dexamethasone Entrapment and Release of Niosomes

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Abstract

Multilamellar niosomes entrapping Dexamethasone (Dex) were prepared by thin film hydration, sonication, respectively. The influence of different processing variables (sonication time, temperature) and formulation variable (cholesterol content) on Dex entrapment efficiency % (EE) was demonstrated. Also, the Dex release from the prepared niosomes in phosphate buffer (pH 7.4) was illustrated. Results indicated that cholesterol increased or decreased the noisome size and EE % depending on its concentration within the formulae. The maximum loading efficiency was 29.2 % when the span 60:cholesterol molar ratio was 100:50 and the hydrating step was conducted by 30 min sonication. Increasing sonication time also increased and then decreased the EE % of Dex into niosomes. Finally, results indicated that in vitro release profiles of Dex from all niosome formulations is an apparently biphasic release process and 5–15 % of drug released from niosomes after 8 h incubation in buffer, depending on the type of niosome.

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Authors and Affiliations

  1. Institute of Inorganic Chemistry II, Ulm University, Ulm, Germany

    Mohammad Amin Mavaddati

  2. Biomaterials Group, Faculty of Biomedical Engineering (Center of Excellence), Amirkabir University of Technology, P.O Box 15875-4413, Tehran, Iran

    Fathollah Moztarzadeh & Fatemeh Baghbani

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  1. Mohammad Amin Mavaddati
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  2. Fathollah Moztarzadeh
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  3. Fatemeh Baghbani
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Correspondence to Fatemeh Baghbani.

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Mavaddati, M.A., Moztarzadeh, F. & Baghbani, F. Effect of Formulation and Processing Variables on Dexamethasone Entrapment and Release of Niosomes. J Clust Sci 26, 2065–2078 (2015). https://doi.org/10.1007/s10876-015-0908-4

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  • DOI: https://doi.org/10.1007/s10876-015-0908-4

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