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Alteration of the Expression of CD4 Isoforms in Oral Epithelia and Saliva from Patients with Oral Lichen Planus

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An Erratum to this article was published on 18 October 2007

Abstract

Oral lichen planus (OLP) is a chronic inflammatory mucosal disease that cell-mediated immunological mechanisms are involved in pathogenesis. The objective of this study was to investigate the expression of CD44 isoforms including CD44s, CD44v5, and CD44v6 in biopsy specimens and saliva from OLP patients. Thirty-one OLP patients and 30 healthy subjects were enrolled in this study. Immunohistochemical methods were used to detect the expression of CD44 isoforms in oral epithelia, and enzyme-linked immunosorbent assay (ELISA) was performed to measure levels of salivary CD44 isoforms. Our results demonstrated that expression of CD44v6 in oral epithelia from OLP patients was significantly decreased in comparison to controls (p = 0.021). Levels of salivary CD44s and CD44v5 from OLP patients were significantly higher than those from controls (p = 0.007 and p = 0.002, respectively). In summary, our findings provided additional evidence that the pathological stress, such as chronic inflammation, altered the expression of CD44 isoforms in oral epithelia and saliva of OLP patients.

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Acknowledgements

This research work was supported by The Thailand Research Fund (# MRG4880152). The authors would like to express our thanks to Dr. Wichian Chowsrikul for providing biopsy specimens used as positive controls and to Dr. Richard L. Gregory for his contribution on reviewing this manuscript. The authors also thank the Research Unit in Oral Diseases, Faculty of Dentistry, Chulalongkorn University for previous support. Finally, we would like to thank the staff of the Department of Oral Diagnosis, Faculty of Dentistry, Khon Kaen University and the staff of the Departments of Oral Medicine and Oral Pathology, Faculty of Dentistry, Chulalongkorn University for their assistance.

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Authors and Affiliations

  1. Department of Oral Diagnosis, Faculty of Dentistry, Khon Kaen University, Khon Kaen, 40002, Thailand

    Ponlatham Chaiyarit, Pensri Phothipakdee & Ajiravudh Subarnbhesaj

  2. Department of Oral Medicine, Faculty of Dentistry, Chulalongkorn University, Bangkok, 10330, Thailand

    Kobkan Thongprasom & Pornpan Piboonratanakit

  3. Department of Oral and Maxillofacial Surgery,Faculty of Dentistry, Khon Kaen University, Khon Kaen, 40002, Thailand

    Sajee Satayut & Supakit Limlertmongkol

  4. Department of Oral Pathology, Faculty of Dentistry, Chulalongkorn University, Bangkok, 10330, Thailand

    Kittipong Dhanuthai

  5. Dental Division, Saraburi Hospital, Saraburi, 18000, Thailand

    Mantharop Chaimusig

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  1. Ponlatham Chaiyarit
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An erratum to this article can be found at http://dx.doi.org/10.1007/s10875-007-9136-5

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Chaiyarit, P., Thongprasom, K., Satayut, S. et al. Alteration of the Expression of CD4 Isoforms in Oral Epithelia and Saliva from Patients with Oral Lichen Planus. J Clin Immunol 28, 26–34 (2008). https://doi.org/10.1007/s10875-007-9128-5

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