Abstract
Ceramic-polymer hybrid particles, intended for osteomyelitis treatment, were fabricated by preparing poly(lactic-co-glycolic acid) particles through an emulsion solvent evaporation technique, followed by calcium phosphate (CaP) coating via a surface adsorption-nucleation method. The presence of CaP coating on the surface of the particles was confirmed by scanning electron microscopy, energy-dispersive X-ray spectroscopy, and X-ray photoelectron spectroscopy. Subsequently, two antibiotics for treating bone infection, nafcillin (hydrophilic) and levofloxacin (amphiphilic), were loaded into these hybrid particles and their in vitro drug release studies were investigated. The CaP coating was shown to reduce burst release, while providing sustained release of the antibiotics for up to 4 weeks. In vitro bacterial study against Staphylococcus aureus demonstrated the capability of these antibiotic-loaded hybrid particles to inhibit biofilm formation as well as deteriorate established biofilm, making this hybrid system a potential candidate for further investigation for osteomyelitis treatment.
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Acknowledgments
The authors would like to thank the National Medical Research Council (NMRC: NMRC/EDG/0062/2009), A*STAR (Project No: 102 129 0098), and the National Research Foundation (NRF) and Ministry of Education, Singapore (MOE) under its Research Centre of Excellence Programme, Singapore Centre on Environmental Life Sciences Engineering (SCELSE) (M4220001.C70) and the Start-up Grants (M020070200) from Nanyang Technological University, Singapore.
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Bastari, K., Arshath, M., NG, Z.H.M. et al. A controlled release of antibiotics from calcium phosphate-coated poly(lactic-co-glycolic acid) particles and their in vitro efficacy against Staphylococcus aureus biofilm. J Mater Sci: Mater Med 25, 747–757 (2014). https://doi.org/10.1007/s10856-013-5125-9
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DOI: https://doi.org/10.1007/s10856-013-5125-9