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Hyaluronic acid/mildly crosslinked alginate hydrogel as an injectable tissue adhesion barrier

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Abstract

Although hyaluronic acid (HA) has been conventionally utilized as a tissue adhesion barrier material, its rapid clearance in the body still remains as a big challenge in the clinical practice. In this study, we prepared a hydrogel of HA embedded in mildly crosslinked alginate (HA/mcALG hydrogel), which is injectable, easily covers injured tissues, and remains stably at the applied site during wound healing (by muco-adhesive HA embedded in the network structure of the mcALG hydrogel). The HA/mcALG hydrogel was highly effective for the prevention of peritoneal tissue adhesion compared to HA and mcALG hydrogels, and did not lead to any abnormal tissue responses during wound healing. The HA/mcALG hydrogel can be a good candidate as an injectable tissue adhesion barrier for clinical applications.

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Acknowledgments

This research was supported by the Pioneer Research Center Program through the National Research Foundation of Korea funded by the Ministry of Education, Science and Technology (2011-0001804).

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Authors and Affiliations

  1. Department of Advanced Materials, Hannam University, 461-6 Jeonmin Dong, Yuseong Gu, Daejeon, 305-811, Republic of Korea

    Seung Yeon Na, Se Heang Oh & Jin Ho Lee

  2. Department of Pathology, School of Medicine, Chungnam National University, Daejeon, 301-131, Republic of Korea

    Kyu Sang Song

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  1. Seung Yeon Na
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Correspondence to Jin Ho Lee.

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Na, S.Y., Oh, S.H., Song, K.S. et al. Hyaluronic acid/mildly crosslinked alginate hydrogel as an injectable tissue adhesion barrier. J Mater Sci: Mater Med 23, 2303–2313 (2012). https://doi.org/10.1007/s10856-012-4689-0

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