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Grafting of poly(ethylene glycol) monoacrylates on polycarbonateurethane by UV initiated polymerization for improving hemocompatibility

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Abstract

Poly(ethylene glycol) monoacrylates (PEGMAs) with a molecular weight between 400 and 1,000 g mol−1 were grafted by ultraviolet initiated photopolymerization on the surface of polycarbonateurethane (PCU) for increasing its hydrophilicity and improving its hemocompatibility. The surface-grafted PCU films were characterized by Fourier transformation infrared spectroscopy, X-ray photoelectron spectroscopy, water contact angle, scanning electron microscopy (SEM) and atomic force microscopy measurements. The surface properties of the modified films were studied in dry and wetted state. Blood compatibility of the surfaces was evaluated by platelet adhesion tests and adhered platelets were determined by SEM. The results showed that the hydrophilicity of the films had been increased significantly by grafting PEGMAs, and platelets adhesion onto the film surface was obviously suppressed. Furthermore, the molecular weight of PEGMAs had a great effect on the hydrophilicity and hemocompatibility of the PCU films after surface modification and increased with increasing molecular weight of PEGMAs.

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Acknowledgments

This work has been financially supported by the Program of Introducing Talents of Discipline to Universities of China (No. B06006), the Science and Technology Project of Tianjin Municipal Science and Technology Commission, No. 08ZCKFSF03300, and by the International Cooperation from Ministry of Science and Technology of China (Grant No. 2008DFA51170) as well as by the Tianjin University-Helmholtz–Zentrum Geesthacht Joint Laboratory for Biomaterials and Regenerative Medicine, which is financed by MOST and the German Federal Ministry of Education and Research (BMBF) (Grant No. 0314596).

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Authors and Affiliations

  1. Key Laboratory of Systems Bioengineering, Ministry of Education, School of Chemical Engineering and Technology, Tianjin University, Tianjin, 300072, China

    Yakai Feng, Haiyang Zhao, Jintang Guo & Dazhi Yang

  2. Tianjin University–Helmholtz-Zentrum Geesthacht, Joint Laboratory for Biomaterials and Regenerative Medicine, Weijin Road 92, 300072 Tianjin, China, Kantstr. 55, 14513, Teltow, Germany

    Yakai Feng, Marc Behl, Andreas Lendlein & Jintang Guo

  3. Center for Biomaterial Development and Berlin Brandenburg Center for Regenerative Therapies (BCRT), Institute of Polymer Research, Helmholtz-Zentrum Geesthacht, Kantstr. 55, 14513, Teltow, Germany

    Marc Behl & Andreas Lendlein

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  1. Yakai Feng
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Correspondence to Yakai Feng.

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Feng, Y., Zhao, H., Behl, M. et al. Grafting of poly(ethylene glycol) monoacrylates on polycarbonateurethane by UV initiated polymerization for improving hemocompatibility. J Mater Sci: Mater Med 24, 61–70 (2013). https://doi.org/10.1007/s10856-012-4685-4

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  • DOI: https://doi.org/10.1007/s10856-012-4685-4

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