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Effect of chitosan multilayers encapsulation on controlled release performance of drug-loaded superparamagnetic alginate nanoparticles

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Abstract

The near monodispersed ibuprofen-loaded superparamagnetic alginate (AL/IBU/Fe3O4) nanoparticles with particles size less than 200 nm were prepared via the facile heterogeneous coprecipitation of the superparamagnetic Fe3O4 nanoparticles, sodium alginate (AL) and the model drug ibuprofen (IBU) from the aqueous dispersion. Then the chitosan multilayers were self-assembled onto the AL/IBU/Fe3O4 nanoparticles to produce novel magnetic-targeted controlled release drug delivery system, with chitosan as the polycation (CS) and the carboxymethyl chitosan (CMCS) as the polyanion. The drug controlled releasing behaviors of the AL/IBU/Fe3O4 nanoparticles and the CS multilayers encapsulated ibuprofen-loaded superparamagnetic alginate ((AL/IBU/Fe3O4)@(CS–CMCS)3) nanoparticles were compared in the different pH media. In media with the same pH value, the encapsulated vessels exhibited the slower releasing rate.

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Acknowledgments

This Project was granted financial support from the National Nature Science Foundation of China (Grant No. 20904017), the Program for New Century Excellent Talents in University (Grant No. NCET-09-0441) and the Fundamental Research Funds for the Central Universities (Grant No. lzujbky-2012-k12).

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Authors and Affiliations

  1. State Key Laboratory of Applied Organic Chemistry and Institute of Polymer Science and Engineering, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, 730000, China

    Chunyin Lu & Peng Liu

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  1. Chunyin Lu
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  2. Peng Liu
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Correspondence to Peng Liu.

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Lu, C., Liu, P. Effect of chitosan multilayers encapsulation on controlled release performance of drug-loaded superparamagnetic alginate nanoparticles. J Mater Sci: Mater Med 23, 393–398 (2012). https://doi.org/10.1007/s10856-011-4477-2

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  • DOI: https://doi.org/10.1007/s10856-011-4477-2

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