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Synthesis of PVP-coated ultra-small Fe3O4 nanoparticles as a MRI contrast agent

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Abstract

Ultra-small Fe3O4 nanoparticles were prepared by using the coprecipitation method, in which the polyvinylpyrrolidone (PVP) serves as a stabilizer. The nanoparticles were characterized by means of X-ray diffraction (XRD), transmission electron microscopy (TEM), infra spectrum (IR), X-ray photoelectron spectroscopy (XPS) and in vivo magnetic resonance imaging (MRI) test. The results showed that the particles’ size was determined by the dripping rate and that PVP molecules played the role of preventing the aggregation and restricting the size of Fe3O4 nanoparticles. The Fe3O4 nanoparticles with diameter from 6.5 to 1.9 nm obviously exhibited negative contrast enhancement and concentrated at the target area guided by a permanent magnet.

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Acknowledgments

This work was supported by National Natural Science Foundation of China under Grant No. 50331030 and 50831006.

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Authors and Affiliations

  1. Shenyang National Laboratory for Materials Science, Institute of Metal Research, and International Centre for Materials Physics, Chinese Academy of Sciences, 72 Wenhua Road, 110016, Shenyang, People’s sRepublic of China

    Ying Zhang, Song Ma, Ya-Jing Zhang, Xiang-Dong Zhang & Zhi-Dong Zhang

  2. College of Pharmaceutical Engineering, Shen Yang Pharmaceutical University, 103 Wenhua Road, Shenyang, 110016, People’s Republic of China

    Ying Zhang, Jing-Ying Liu & Xiang Zhao

  3. College of Chemical Science and Engineering, Liao Ning University, Shenyang, 110036, Peoples’ Republic of China

    Xiang-Dong Zhang

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  1. Ying Zhang
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  2. Jing-Ying Liu
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  3. Song Ma
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  4. Ya-Jing Zhang
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  5. Xiang Zhao
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  7. Zhi-Dong Zhang
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Correspondence to Ying Zhang.

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Zhang, Y., Liu, JY., Ma, S. et al. Synthesis of PVP-coated ultra-small Fe3O4 nanoparticles as a MRI contrast agent. J Mater Sci: Mater Med 21, 1205–1210 (2010). https://doi.org/10.1007/s10856-009-3881-3

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  • DOI: https://doi.org/10.1007/s10856-009-3881-3

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