Abstract
Oral drug administration is convenient with pH dependent drug delivery system since the drug has to pass through different pH environments in gastro intestinal (GI) tract. The pH dependent swelling/shrinking behavior of hydrogel drug carrier controls the drug release without affecting the function of drug. pH dependent hydrogels of poly (vinyl alcohol) (PVA) were prepared by cross linking with maleic acid (MA). The hydrogels were characterized by attenuated total reflectance-Fourier transform infrared (ATR-FTIR) spectroscopy, DSC, porosimetry, SEM, TEM, biocompatibility study and by measuring their swelling behavior in water, simulated gastric fluid (SGF) and intestinal fluid (SIF). Swelling of the hydrogels was found to be highest in SIF (pH: 7.5) and lowest in SGF (pH: 1.2) resembling that required in colon targeted drug delivery systems. Since the swelling behavior of the gel is pH dependent, these hydrogels were studied for colon targeted drug delivery in an in-vitro set-up resembling the condition of GI tract. The ratio of PVA and MA in the hydrogel was varied to study the effect on the drug diffusion rate. For drug delivery study, vitamin B12 and salicylic acid were used as model drugs. The hydrogel, loaded with model drugs vitamin B12 and salicylic acid also demonstrated colon specific drug release with a relatively higher drug release in SIF (pH: 7.5) than that in SGF (pH: 1.2).
Similar content being viewed by others
References
L.B. Peppas, N.A. Peppas, Biomaterials 11(9), 635 (1990)
Y. Qiu, K. Park, Adv. Drug Delivery Rev. 53(3), 321 (2001)
E.O. Akala, P. Kopeckova, J. Kopecek, Biomaterials 19(11–12), 1037 (1998)
M.K. Chourasia, S.K. Jain, J. Pharm. Pharmaceut. Sci. 6(1), 33 (2003)
A.R. Khare, N.A. Peppas, J. Biomater. Sci. Polym. 4(3), 275 (1993)
S.J. Kim, S.J. Park, S.I. Kim, React. Funct. Polym. 55(1), 53 (2003)
L.F. Gudeman, N.A. Peppas, J. Appl. Polym. Sci. 55(6), 919 (1995)
H.S. Shin, S.Y. Kim, Y.M. Lee, K.H. Lee, S.J. Kim, C.E. Rogers, J. Appl. Polym. Sci. 69(3), 479 (1998)
N.A. Peppas, S.L. Wright, Eur. J. Pharm. Biopharm. 46(1), 15 (1998)
S.G. Gholap, J.P. Jog, M.V. Badiger, Polymer 45(17), 5863 (2004)
A.K. Gupta, S. Wells, IEEE Trans. Nanobiosci. 3(1), 66 (2004)
D.Q. Wu, X.Z. Zhang, C.C. Chu, Am. J. Drug Delivery 3(4), 253 (2005)
J.M. Gohil, A. Bhattacharya, P. Ray, J. Polym. Res. 13(2), 161 (2006)
C. Xiao, G. Zhou, Polym. Degrad. Stab. 81(2), 297 (2003)
S.L. Bourke, M. Al-Khalili, T. Briggs, B.B. Michniak, J. Kohn, L.A. Poole-Warren, AAPS Pharm. Sci. 5(4), Article 33 (2003)
R.J. Majithiya, P.K. Ghosh, M.L. Umrethia, R.S.R. Murthy, AAPS Pharm. Sci. 7(3), Article 67 (2006)
S. Oya, A. Gülsen, J. Appl. Polym. Sci. 91(1), 72 (2004)
S.C. Mendes, R.L. Reis, Y.P. Bovell, A.M. Cunha, C.A. van Blitterswijk, J.D. de Bruijn, Biomaterials 22(14), 2057 (2001)
M. Morraa, C. Cassinellia, G. Cascardoa, P. Cahalanb, L. Cahalanb, M. Finic, R. Giardinoc, Biomaterials 24(25), 4639 (2003)
S. Maoa, X. Shuaia, F. Ungera, M. Wittmara, X. Xiec, T. Kissela, Biomaterials 26(32), 6343 (2005)
D. Fischera, Y. Lib, B. Ahlemeyerc, J. Krieglsteinc, T. Kissela, Biomaterials 24(7), 1121 (2003)
K.L. Shantha, D.R.K. Harding, Eur. Polym. J. 39(1), 63 (2003)
A.R. Gennaro, Remington: The Science and Practice of Pharmacy, 19th edn. (Mack Publishing Company, Easton, Pennsylvania, 1995), pp. 1123–1125
S. Sumathi, A.R. Ray, J. Pharm. Pharmaceut. Sci. 5(1), 12 (2002)
D.R. Friend, Adv. Drug Delivery Rev. 57(2), 247 (2005)
Th.F. Vandamme, A. Leonourry, C. Charrueau, J.-C. Chaumeil, Carbohydr. Polym. 48(3), 219 (2002)
L. Liua, M.L. Fishmana, J. Kostb, K.B. Hicksa, Biomaterials 24(19), 3333 (2003)
H.S. Mansur, R.L. Oréfice, A.A.P. Mansur, Polymer 45(21), 7193 (2004)
L.H. Sperling, Introduction to Physical Polymer Science, 2nd edn. (Wiley, USA, 1992), pp. 389–390
L.F. Gudeman, N.A. Peppas, J. Membr. Sci. 107(3), 239 (1995)
S.K. Bajpai, S. Dubey, React. Funct. Polym. 62(1), 93 (2005)
J. Park, J. Park, E. Ruckenstein, J. Appl. Polym. Sci. 82(7), 1816 (2001)
C. Ferrero, I. Bravo, M.R. Jiménez-Castellanos, J. Controlled Release 92(1–2), 69 (2003)
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Basak, P., Adhikari, B. Poly (vinyl alcohol) hydrogels for pH dependent colon targeted drug delivery. J Mater Sci: Mater Med 20 (Suppl 1), 137–146 (2009). https://doi.org/10.1007/s10856-008-3496-0
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10856-008-3496-0