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Optimizing the alginate coating layer of doxorubicin-loaded iron oxide nanoparticles for cancer hyperthermia and chemotherapy

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Abstract

Chemotherapy in cancer treatment usually leads to serious side effects on patients due to the unselectiveness and high toxicity on normal cells of cancer drugs. Loading cancer drugs into nano-platforms could be an alternative approach to effectively deliver drugs to tumors and reduce toxic exposure on healthy cells. In this work, we synthesized drug delivery nano-systems based on Fe3O4 nanoparticles (obtained from co-precipitation reaction) which could provide targeting of drugs to the tumor sites by an external magnetic field. Also, the magnetic nanoparticles (MNPs) could generate heat to kill cancer cells at a certain temperature range. The systems were designed for loading anticancer agent doxorubicin by using alginate-coated iron oxide MNPs. It was found that the loading was achieved by complex formation of doxorubicin and the alginate layer. Various concentrations of alginate solutions produced different sizes as well as drug loading capacities of the nanoparticles. The highest loading content of 18.96% achieved at the alginate concentration of 4 mg ml−1, corresponding to the mass ratio of alginate to Fe3O4 of around 1:2. The magnetic properties, especially the inductive heating effect of the nanoparticles, along with the impact of the systems on tumor cells were investigated. The results proved that the nanoparticles can serve as a good drug delivery system, in terms of both effective hyperthermia and chemotherapy.

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Acknowledgements

This work was financially supported by the National Foundation for Science and Technology Development of Vietnam-NAFOSTED under Grant No. 106-YS.06-2015.14 (HPT). The authors would like to thank Dr. Ung Thi Dieu Thuy for her fluorescence measurement and Ms. Cao Phuong Lien for her English proofreading.

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Authors and Affiliations

  1. Institute of Materials Science, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet Road, Cau Giay District, Hanoi, Vietnam

    Thi Thu Huong Le, Hong Nam Pham & Phuong Thu Ha

  2. Vietnam National University of Agriculture, Trau Quy, Gia Lam District, Hanoi, Vietnam

    Thi Thu Huong Le

  3. Graduate University of Science and Technology, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet Road, Cau Giay District, Hanoi, Vietnam

    Thi Thu Huong Le

  4. Hanoi Medical University, 1 Ton That Tung, Dong Da District, Hanoi, Vietnam

    Thuc Quang Bui

  5. Hue University of Medicine and Pharmacy, Hue, Vietnam

    Thi Minh Thi Ha

  6. Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet Road, Cau Giay District, Hanoi, Vietnam

    Mai Huong Le

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  1. Thi Thu Huong Le
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Correspondence to Phuong Thu Ha.

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The authors declare no conflict of interest. The funding sponsors had no role in the design of the study; in the collection, analyses or interpretation of data; in the writing of the manuscript; and in the decision to publish the results.

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Le, T.T.H., Bui, T.Q., Ha, T.M.T. et al. Optimizing the alginate coating layer of doxorubicin-loaded iron oxide nanoparticles for cancer hyperthermia and chemotherapy. J Mater Sci 53, 13826–13842 (2018). https://doi.org/10.1007/s10853-018-2574-z

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