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The potential of seaweed as a source of drugs for use in cancer chemotherapy

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Abstract

This review discusses studies on marine macroalgae that have been investigated for their potential as sources of novel anti-cancer drugs. The review highlights the very large number of studies of crude, partially purified and purified seaweed extracts, collected from many locations, which have shown potential as sources of potent anti-cancer drugs when tested in vitro and/or in vivo. The activity of polysaccharides, polyphenols, proteinaceous molecules, carotenoids, alkaloids, terpenes and others is described here. In some reports, mechanistic studies have identified specific inhibitory activity on a number of key cellular processes including apoptosis pathways, telomerase and tumour angiogenesis. However, despite the potential shown by these studies, translation to clinically useful preparations is almost non-existent. It is hoped this review will serve as a source document and guide for those carrying out research into the potential use of macroalgae as a source of novel anti-cancer agents.

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Acknowledgments

This study was supported by the FUSION programme, Intertrade Ireland.

Author information

Authors and Affiliations

  1. Cybercolloids Ltd, Unit 4A, Site 13, Carrigaline Industrial Estate, Carrigaline, County Cork, Ireland

    Catherine Murphy & Sarah Hotchkiss

  2. Axis Bioservices Ltd, Coleraine, Northern Ireland, UK

    Jenny Worthington

  3. School of Biomedical Sciences, University of Ulster, Coleraine, Northern Ireland, UK

    Stephanie R. McKeown

Authors
  1. Catherine Murphy
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  2. Sarah Hotchkiss
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  3. Jenny Worthington
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  4. Stephanie R. McKeown
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Corresponding author

Correspondence to Catherine Murphy.

Glossary

4T1

Murine mammary tumour

13762 MAT

Rat mammary adenocarcinoma

1301

Human T cell leukaemia

A20

Murine reticulum cell sarcoma

A549

Human lung adenocarcinoma

AAPH

2,2-Azobis(2-amidinopropane) dihydrochloride

AGS

Human gastric adenocarcinoma

AIF

Apoptosis inducing factor

AMVN

2,2-Azobis(2,4-dimethylvaleronitrile)

B-16

Murine melanoma

B16-BL6

Murine melanoma

B16-F10

Murine melanoma

BCNU

Carmustine

BEL-7402

Human hepatocellular carcinoma

BSC

Monkey kidney cells

BXPC3

Human primary pancreatic adenocarcinoma

C32

Human melanoma

Caco-2

Human epithelial colorectal adenocarcinoma

CCL39

Chinese hamster fibroblasts

Cdk

Cyclin-dependent kinases

CHO

Chinese hamster ovary

Colo320DM

Human colon adenocarcinoma

COX-2

Cyclooxygenase-2

CT-26

Murine colon cancer

Cx

Connexin

Daudi

Human Burkitt’s lymphoma

DC

Dendritic cells

DLD-1

Human colorectal adenocarcinoma

DU-145

Human prostate cancer

ED-40515(−)

Human leukaemia T cell line

ENN

N-Ethyl-N′-nitro-N-nitrosoguanidine

ERCC1

Excision repair cross complementation 1

ERK

Extracellular signal-regulated kinases

FBHE

Foetal bovine heart endothelial

FGF

Fibroblast growth factor

FHC

Human colon epithelial

FHs 74 Int

Human normal intestinal

GADD45A

Growth arrest and DNA-damage-inducible protein

GCSF

Granulocyte colony-stimulating factor

GOTO

Human neuroblastoma cells

GSH

Glutathione

GSH-PX

Glutathione peroxidase

H22

Murine hepatoma

HCT-116

Human colon cancer cells

HCT-15

Human colorectal adenocarcinoma cells

HCT-8

Human colon cancer cells

HeLa

Human cervical cancer cells

HEp-2

Epidermoid carcinoma cells

HepG2

Liver cancer cells

HL-60

Human leukaemia

HMEC-1

Human microvascular endothelial cells

HOS

Human osteosarcoma cells

HT1080

Human fibrosarcoma cells

HT-29

Human colon adenocarcinoma cells

HTLV-1

Human T cell leukaemia virus type 1

HS-Sultan cells

Human lymphoma

Hs 677.st

Human stomach fibroblasts

HUT-102

Human cutaneous T lymphocytes

HUVEC

Human umbilical vein endothelial cells

H1299

Non-small cell lung cancer cells

ICR

Imprinting control region mice

IEC-6

Rat normal intestinal epithelial cells

IGF-IR

Insulin-like growth factor-I receptor

JAK/STAT

Janus kinase/signal transducer and activator of transcription

JB6 Cl41

Normal murine epidermis

Jurkat

Human T cell leukaemia

K562

Human chronic myelogenous leukaemia

KB

Human nasopharynx carcinoma

L-1210

Mouse lymphocytic leukaemia

L929

Murine fibrosarcoma

LLC

Lewis lung carcinoma

LNCaP

Human prostate adenocarcinoma

LOVO

Human colorectal adenocarcinoma

LS-174

Human colonic adenocarcinoma cells

MiaPaCa-2

Human pancreatic carcinoma

MAPK

Mitogen-activated protein kinase

MCF-7

Human breast adenocarcinoma

MDA

Malondialdehyde, an oxidative stress marker

MDA-MB-231

Human mammary adenocarcinoma

MDA-MB-435

Human mammary carcinoma

MDCK

Madine–Darby canine kidney

MDSC

Myeloid-derived suppressor cells

MEL-28

Human melanoma

MG-63

Human osteosarcoma

MGC-803

Human gastric cancer

MKN-45

Human gastric adenocarcinoma

MMP

Matrix metalloproteinase

MOLT-4

Human lymphoblastic leukaemia

MRC-5

Human lung fibroblast

MT-2

Human lymphocyte infected with HTLV-1

MT-4

Human T cell leukaemia

NF-κB

Nuclear factor κB

NSCLC-N6

Human non-small cell bronchopulmonary carcinoma line

P-388

Murine leukaemic cells

Panc-1

Human pancreatic carcinoma

Panc-3.27

Human pancreatic cancer

PAI-1

Plasminogen activator inhibitor-1

PBMC

Peripheral blood mononuclear cells

PCNA

Proliferating cell nuclear antigen

PC-3

Human prostate cancer

PtK1

Potorous tridactylis normal kidney cells

RAW264.7

Mouse leukaemic monocyte macrophage cell line

RIF-1

Radiation-induced fibrosarcoma

RPMI-7951

Human malignant melanoma obtained from the lymph node

S-180

Sarcoma 180

SAPK/JNK

Stress-activated protein kinase/Jun-amino-terminal kinase

SF-295

Brain

SK-MEL-28

Human malignant melanoma

SF-295

Human glioblastoma

SK-MEL-28

Human malignant melanoma

SK Hep-1

Human hepatocellular carcinoma

SMMC-7721

Human hepatocellular carcinoma

SW-480

Human colon carcinoma

THP 1

Human leukaemia

TJ

Tight junction (proteins)

TNF-α

Tumour necrosis factor-alpha

TPA

12-O-Tetradecanoylphorbol-13-acetate

TRAIL

TNF-related apoptosis-inducing ligand

uPAR

Urinary human urokinase-type plasminogen activator receptor

U-937

Human leukaemic monocyte lymphoma

V79-4

Chinese hamster lung fibroblasts

VEGF

Vascular endothelial growth factor

Vero

African green monkey kidney

WHCO1

Human oesophageal cancer

WiDr

Colon adenocarcinoma cell

XC

Rat sarcoma

YAC-1

Murine lymphoma

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Murphy, C., Hotchkiss, S., Worthington, J. et al. The potential of seaweed as a source of drugs for use in cancer chemotherapy. J Appl Phycol 26, 2211–2264 (2014). https://doi.org/10.1007/s10811-014-0245-2

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  • DOI: https://doi.org/10.1007/s10811-014-0245-2

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