Abstract
Although the up-regulation of periostin in osteoarthritic (OA) is found, its function on OA condyle caused by disc displacement is not clear. Our objective was to explore whether periostin has any effect on condylar resorption. We initially identified periostin-positive cells in temporomandibular joint osteoarthritic (TMJ-OA) cartilage. Furthermore, the vitro analysis confirmed that the expression of periostin in chondrocytes treated with a static pressure of 150 kpa and 200 kpa for 3 h by an in-house-designed pressure chamber. To explore the underlying mechanism, we found that periostin can induce IκBα phosphorylation and its subsequent degradation, leading to consequent p65 nuclear translocation and subsequent induction of ADAMTS5 expression, which is known to be detrimental to cartilage extracellular matrix production. Importantly, inhibiting NF-κB signaling, by BAY 11-7082 treatment, rescued periostin-induced ADAMTS5 up-regulation. This study elucidated the direct role of periostin in condylar resorption, which was found to occur via NF-κB-ADAMTS5 signaling. Inhibition of this pathway might provide a new strategy for TMJ-OA treatment.
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Funding
This study was supported by the National Natural Science Foundation of China in 2016 (81671010) and Western Medicine Guidance Project of Shanghai Science and Technology Commission(16411960800)..
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All human tissues were collected according to the informed protocol approved by Independent Ethics Committee of Shanghai Ninth People’s Hospital affiliated to Shanghai JiaoTong University, School of Medicine.
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Fan, B., Liu, X., Chen, X. et al. Periostin Mediates Condylar Resorption via the NF-κB-ADAMTS5 Pathway. Inflammation 43, 455–465 (2020). https://doi.org/10.1007/s10753-019-01129-4
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DOI: https://doi.org/10.1007/s10753-019-01129-4