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Anti-inflammation Effects of Sophora flavescens Nanoparticles

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Abstract

The roots of Sophora flavescens was reported to possess many pharmacological activities including anti-inflammatory, antiashmatic, antithelmintic, free radical scavenging and antimicrobial activities. However, the low saturated solubility and dissolution velocity of S. flavescens lead to poor bioavailability. The S. flavescens nanoparticles (SFNP) were prepared by a combination of ultrasound and hydrolysis developed by the authors. The drug dissolution profiles of SFNP in both pH 6.8 and pH 2 media showed complete dissolution within 30 min. The seropharmacology study showed that oral S. flavescens absorption in the SFNP was significantly increased. Anti-inflammation assay revealed the therapeutic efficiency of S. flavescens significantly enhanced upon nanoparticle formation.

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Acknowledgments

This project was supported by a project of Shandong Province Higher Educational Science and Technology Program (J08LH62).

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Authors and Affiliations

  1. School of Pharmacy, Shandong University of Tradtional Chinese Medicine, Jinan, 250355, People’s Republic of China

    Chun-Chao Han

  2. Department of Pharmacy, Beijing University of Traditional Chinese Medicine, Beijing, 100102, People’s Republic of China

    Yingzi Wang

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  1. Chun-Chao Han
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  2. Yingzi Wang
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Correspondence to Yingzi Wang.

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Han, CC., Wang, Y. Anti-inflammation Effects of Sophora flavescens Nanoparticles. Inflammation 35, 1262–1268 (2012). https://doi.org/10.1007/s10753-012-9437-6

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