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Immunohistochemical analysis of connective tissue in patients with pelvic organ prolapse

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Abstract

The uterosacral ligaments are an important part of the pelvic support system. The objective of this study was to compare the expression of collagen type I and collagen type III in the uterosacral ligament biopsies from women with and without pelvic organ prolapse (POP). The uterosacral ligament biopsies were obtained from women with POP (n = 29) and non-POP subjects (n = 35). Immunohistochemistry for collagen type I and collagen type III was performed on formalin-fixed and paraffin-embedded sections. The two groups were matched for age, body mass index, parity and postmenopausal status. The expression of collagen type I (p < 0.001) and collagen type III (p < 0.0001) differed between women with POP and non-POP subjects. There was decreased expression of collagen type I and increased expression of collagen type III in uterosacral ligaments of women with POP compared with non-POP subjects. This difference indicates a possible relationship between POP and the immunohistochemical expression of collagen type I and collagen type III in uterosacral ligaments.

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Authors and Affiliations

  1. Clinics of Gynecology and Obstetric, Goztepe Training and Research Hospital, Istanbul Medeniyet University, Istanbul, Turkey

    Nese Yucel, Akın Usta, Kadir Guzin & Ergun Bilgic

  2. Department of Histology and Embryology, Faculty of Medicine, Istanbul Medeniyet University, 34730, Istanbul, Turkey

    Mehmet Kanter & Mustafa Ozgul

  3. Department of Pathology, Fatih Sultan Mehmet Training and Research Hospital, Istanbul, Turkey

    Nurver Ozbay Ozel

Authors
  1. Nese Yucel
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  2. Akın Usta
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  3. Kadir Guzin
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  4. Mehmet Kanter
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  5. Ergun Bilgic
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  6. Nurver Ozbay Ozel
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  7. Mustafa Ozgul
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Correspondence to Kadir Guzin.

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Yucel, N., Usta, A., Guzin, K. et al. Immunohistochemical analysis of connective tissue in patients with pelvic organ prolapse. J Mol Hist 44, 97–102 (2013). https://doi.org/10.1007/s10735-012-9456-5

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  • DOI: https://doi.org/10.1007/s10735-012-9456-5

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