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Sialidase significance for cancer progression

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Abstract

Aberrant glycosylation is a characteristic feature of cancer cells. In particular, altered sialylation is closely associated with malignant properties, including invasiveness and metastatic potential. To elucidate the molecular mechanisms underlying the aberrancy, our studies have focused on mammalian sialidase, which catalyzes the removal of sialic acid residues from glycoproteins and glycolipids. The four types of mammalian sialidase identified to date show altered expression and behave in different manners during carcinogenesis. The present review briefly summarizes results on altered expression of sialidases and their possible roles in cancer progression. These enzymes are indeed factors defining cancer malignancy and thus potential targets for cancer diagnosis and therapy.

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Abbreviations

DANA:

2-deoxy-2,3dehydro-N-acetylneuraminic acid

4MU-NANA:

4-methylumbelliferyl sialic acid

NeuAc:

N-acetyl neuraminic acid

EGFR:

Epidermal growth factor receptor

siRNA:

Small interfering RNA

RT-PCR:

Reverse transcription polymerase chain reaction

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Acknowledgements

This study was supported in part by Grants-in Aid for Exploratory Research and Scientific Research on Priority Areas in Cancer from the Ministry of Education, Culture, Sports, Science and Technology of Japan.

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Authors and Affiliations

  1. Division of Cancer Glycosylation Research, Institute of Molecular Biomembrane and Glycobiology, Tohoku Pharmaceutical University, 981-8558, Sendai, Japan

    Taeko Miyagi, Kohta Takahashi & Keiko Hata

  2. Laboratory of Marine Biochemistry, Faculty of Fisheries, Kagoshima University, Kagoshima, 890-0056, Japan

    Kazuhiro Shiozaki

  3. Division of Molecular and Cellular Oncology, Miyagi Cancer Center Research Institute, Natori, 981-1293, Japan

    Kazunori Yamaguchi

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  1. Taeko Miyagi
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  2. Kohta Takahashi
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  3. Keiko Hata
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  4. Kazuhiro Shiozaki
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  5. Kazunori Yamaguchi
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Correspondence to Taeko Miyagi.

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Miyagi, T., Takahashi, K., Hata, K. et al. Sialidase significance for cancer progression. Glycoconj J 29, 567–577 (2012). https://doi.org/10.1007/s10719-012-9394-1

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  • DOI: https://doi.org/10.1007/s10719-012-9394-1

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