Skip to main content

Advertisement

SpringerLink
Log in

Effect of xylan sulfate on the responsive swelling behavior of poly(methacrylatoethyl trimethyl ammonium chloride)-based composite hydrogels

  • Original Research
  • Published:
Cellulose Aims and scope Submit manuscript

Abstract

Xylan sulfate, one important xylan derivative, was prepared using microfluidic reactor system and incorporated in situ under the polymerization of methacroylcholine chloride (DMC), resulting in composite hydrogels containing variable amount of xylan sulfate. The introduction of xylan sulfate imparts enhanced temperature-swelling responsiveness to the hydrogels, and substantially increases their water swelling ratio up to > 200 g/g, which is twice higher than the neat polyDMC hydrogel. Such swelling behavior may relate to the electrostatic interaction between the –SO3− in xylan sulfate and the –NH4+ in polyDMC. This interaction significantly improves the formation of porous architecture and the tensile toughness of the hydrogels. The composite hydrogels exhibit responsive swelling behavior at different salt, pH, and solvent conditions due to osmotic pressure decline, charge shielding and salting-out effect. They load 2.2 times amount of tetracycline hydrochloride and show 50.3% slower release rate than the neat polyDMC hydrogel, which shows great potential for drug delivery applications.

Graphic abstract

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7
Fig. 8
Fig. 9
Fig. 10
Fig. 11

Similar content being viewed by others

References

  • Ahmed EM (2015) Hydrogel: preparation, characterization, and applications: a review. J Adv Res 6:105–121

    Article  CAS  Google Scholar 

  • Anderson VR, Perry CM (2006) Pentosan polysulfate. Drugs 66:821–835

    Article  CAS  Google Scholar 

  • Barbucci R, Magnani A, Consumi M (2000) Swelling behavior of carboxymethylcellulose hydrogels in relation to cross-linking, pH, and charge density. Macromolecules 33:7475–7480

    Article  CAS  Google Scholar 

  • Bush JR, Liang H, Dickinson M, Botchwey EA (2016) Xylan hemicellulose improves chitosan hydrogel for bone tissue regeneration. Polym Adv Technol 27:1050–1055

    Article  CAS  Google Scholar 

  • Chen Y et al (2019) Flow synthesis, characterization, anticoagulant activity of xylan sulfate from sugarcane bagasse. Int J Biol Macromol 155:1460–1467

    Article  Google Scholar 

  • Cheng H, Liu H, Feng Q, Xie Y, Zhan H (2017) Preparation, characterization and in vitro anticoagulant activity of corn stover xylan sulfates. J Biomat Sci Polym E 28:271–283

    Article  CAS  Google Scholar 

  • Dai H, Huang H (2017) Enhanced swelling and responsive properties of pineapple peel carboxymethyl cellulose-g-poly (acrylic acid-co-acrylamide) superabsorbent hydrogel by the introduction of carclazyte. J Agric Food Chem 65:565–574

    Article  CAS  Google Scholar 

  • Daus S, Petzold-Welcke K, Kötteritzsch M, Baumgaertel A, Schubert US, Heinze T (2011) Homogeneous sulfation of xylan from different sources. Macromol Mater Eng 296:551–561

    Article  CAS  Google Scholar 

  • Debele TA, Mekuria SL, Tsai HC (2016) Polysaccharide based nanogels in the drug delivery system: application as the carrier of pharmaceutical agents. Mater Sci Eng C 68:964–981

    Article  CAS  Google Scholar 

  • Du J, Li B, Li C, Zhang Y, Yu G, Wang H, Mu X (2016) Tough and multi-responsive hydrogel based on the hemicellulose from the spent liquor of viscose process. Int J Biol Macromol 88:451–456

    Article  CAS  Google Scholar 

  • Ebringerová A, Hromádková Z, Heinze T (2005) Hemicellulose. In: Heinze T (ed) Polysaccharides I. Springer, Berlin, pp 1–67

    Google Scholar 

  • Flory PJ (1953) Principles of polymer chemistry. Cornell University Press, New York

    Google Scholar 

  • Gabrielii I, Gatenholm P, Glasser W, Jain R, Kenne L (2000) Separation, characterization and hydrogel-formation of hemicellulose from aspen wood. Carbohydr Polym 43:367–374

    Article  CAS  Google Scholar 

  • Gao C, Ren J, Kong W, Sun R, Chen Q (2015) Comparative study on temperature/pH sensitive xylan-based hydrogels: their properties and drug controlled release. RSC Adv 5:90671–90681

    Article  CAS  Google Scholar 

  • García-Uriostegui L, Delgado E, Meléndez-Ortiz HI, Camacho-Villegas T, Esquivel-Solís H, Gatenholm P, Toriz G (2018) Spruce xylan/HEMA-SBA15 hybrid hydrogels as a potential scaffold for fibroblast growth and attachment. Carbohydr Polym 201:490–499

    Article  Google Scholar 

  • Gong JP (2010) Why are double network hydrogels so tough? Soft Matter 6:2583–2590

    Article  CAS  Google Scholar 

  • Katsuraya K, Nakashima H, Yamamoto N, Uryu T (1999) Synthesis of sulfated oligosaccharide glycosides having high anti-HIV activity and the relationship between activity and chemical structure. Carbohydr Res 315:234–242

    Article  CAS  Google Scholar 

  • Košovan P, Richter T, Holm C (2015) Modeling of polyelectrolyte gels in equilibrium with salt solutions. Macromolecules 48:7698–7708

    Article  Google Scholar 

  • Lian Y, Zhang J, Li N, Ping Q (2018) Preparation of hemicellulose-based hydrogel and its application as an adsorbent towards heavy metal ions. BioResources 13:3208–3218

    Article  CAS  Google Scholar 

  • Liu J, Li Q, Su Y, Yue Q, Gao B (2014) Characterization and swelling–deswelling properties of wheat straw cellulose based semi-IPNs hydrogel. Carbohydr Polym 107:232–240

    Article  CAS  Google Scholar 

  • Liu S, Chen F, Song X, Wu H (2017) Preparation and characterization of temperature- and pH-sensitive hemicellulose-containing hydrogels. Int J Polym Anal Charact 22:187–201

    Article  CAS  Google Scholar 

  • Luo F et al (2015) Oppositely charged polyelectrolytes form tough, self-healing, and rebuildable hydrogels. Adv Mater 27:2722–2727

    Article  CAS  Google Scholar 

  • Madhawan A, Arora A, Das J, Kuila A, Sharma V (2018) Microreactor technology for biodiesel production: a review. Biomass Convers Biorefin 8:485–496

    Article  CAS  Google Scholar 

  • Mandal P, Pujol CA, Damonte EB, Ghosh T, Ray B (2010) Xylans from Scinaia hatei: structural features, sulfation and anti-HSV activity. Int J Biol Macromol 46:173–178

    Article  CAS  Google Scholar 

  • Naidu DS, Hlangothi SP, John MJ (2018) Bio-based products from xylan: a review. Carbohydr Polym 179:28–41

    Article  CAS  Google Scholar 

  • Peng X, Ren J, Zhong L, Peng F, Sun R (2011) Xylan-rich hemicelluloses-graft-acrylic acid ionic hydrogels with rapid responses to pH, salt, and organic solvents. J Agric Food Chem 59:8208–8215

    Article  CAS  Google Scholar 

  • Peng F, Guan Y, Zhang B, Bian J, Ren J, Yao C, Sun R (2014) Synthesis and properties of hemicelluloses-based semi-IPN hydrogels. Int J Biol Macromol 65:564–572

    Article  CAS  Google Scholar 

  • Petzold-Welcke K, Schwikal K, Daus S, Heinze T (2014) Xylan derivatives and their application potential–mini-review of own results. Carbohydr Polym 100:80–88

    Article  CAS  Google Scholar 

  • Qi X et al (2016) Enhanced mechanical performance of biocompatible hemicelluloses-based hydrogel via chain extension. Sci Rep 6:33603

    Article  CAS  Google Scholar 

  • Ren J, Dai Q, Zhong H, Liu X, Meng L, Wang X, Xin F (2018) Quaternized xylan/cellulose nanocrystal reinforced magnetic hydrogels with high strength. Cellulose 25:4537–4549

    Article  CAS  Google Scholar 

  • Sun X, Wang H, Jing Z, Mohanathas R (2013) Hemicellulose-based pH-sensitive and biodegradable hydrogel for controlled drug delivery. Carbohydr Polym 92:1357–1366

    Article  CAS  Google Scholar 

  • Sun XF, Gan Z, Jing Z, Wang H, Wang D, Jin Y (2015) Adsorption of methylene blue on hemicellulose-based stimuli-responsive porous hydrogel. J Appl Polym Sci 132:41606

    Article  Google Scholar 

  • Sun X-F, Zeng Q, Wang H, Hao Y (2019) Preparation and swelling behavior of pH/temperature responsive semi-IPN hydrogel based on carboxymethyl xylan and poly (N-isopropyl acrylamide). Cellulose 26:1909–1922

    Article  CAS  Google Scholar 

  • Utech S, Boccaccini AR (2016) A review of hydrogel-based composites for biomedical applications: enhancement of hydrogel properties by addition of rigid inorganic fillers. J Mater Sci 51:271–310

    Article  CAS  Google Scholar 

  • Wagner W (1989) Hoe/Bay 946—a new compound with activity against the AIDS virus. Arzneimittel-Forschung 39:112

    CAS  PubMed  Google Scholar 

  • Xiao Z et al (2018) Fast swelling behaviors of thermosensitive poly (N-isopropylacrylamide-co-methacryloxyethyltrimethyl ammonium chloride)/Na2WO4 cationic composite hydrogels. J Appl Polym Sci 135:46375

    Article  Google Scholar 

  • Yang J, Du Y, Wen Y, Li T, Hu L (2003) Sulfation of Chinese lacquer polysaccharides in different solvents. Carbohydr Polym 52:397–403

    Article  CAS  Google Scholar 

  • Yuan T, Xu F, He J, Sun R (2010) Structural and physico-chemical characterization of hemicelluloses from ultrasound-assisted extractions of partially delignified fast-growing poplar wood through organic solvent and alkaline solutions. Biotechnol Adv 28:583–593

    Article  CAS  Google Scholar 

Download references

Acknowledgments

The authors thank the financial support by the National Key Research and Development Program of China (2019YFD1101202); Program for the Jiangsu Province Natural Science Foundation for Distinguished Young Scholars (SBK20190035); National Natural Science Foundation of China (21776132, 21878142); Natural Science Foundation of the Jiangsu Higher Education Institutions (19KJB530002); Changjiang Scholars and Innovative Research Team in University (Grant No. IRT_14R28); and Jiangsu National Synergetic Innovation Center for Advanced Bio-Manufacture.

Author information

Authors and Affiliations

  1. College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, 211816, China

    Ming Li, Xiangxiang Sun, Yanjun Chen, Tao Shen, Zhuotao Tan, Chenglun Tang, Wei Zhuang, Chenjie Zhu & Hanjie Ying

Authors
  1. Ming Li
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Xiangxiang Sun
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Yanjun Chen
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Tao Shen
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Zhuotao Tan
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Chenglun Tang
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Wei Zhuang
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Chenjie Zhu
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Hanjie Ying
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to Wei Zhuang or Chenjie Zhu.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Electronic supplementary material

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Li, M., Sun, X., Chen, Y. et al. Effect of xylan sulfate on the responsive swelling behavior of poly(methacrylatoethyl trimethyl ammonium chloride)-based composite hydrogels. Cellulose 27, 8745–8756 (2020). https://doi.org/10.1007/s10570-020-03402-4

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10570-020-03402-4

Keywords

Search

Navigation