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Novel pH-responsive graft copolymer based on HPMC and poly(acrylamide) synthesised by microwave irradiation: application in controlled release of ornidazole

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Abstract

Herein, the microwave-assisted grafting method was employed for the development of a novel pH-responsive graft copolymer derived from polyacrylamide-modified hydroxypropyl methyl cellulose [g-HPMC (M)]. The synthesised copolymer has been used for in vitro sustained release of ornidazole. Various characterizations confirm the formation of graft copolymer. Swelling studies indicate the pH-dependent swelling behaviour, while deswelling studies suggest that g-HPMC (M) shows faster deswelling in response to change in pH and/temperature. The cell viability study signifies that g-HPMC (M) is cytocompatible. The in-vitro release study demonstrates that g-HPMC (M) delivers ornidazole specifically in the colon pH, without release of the drug in the acidic environment, ensuring g-HPMC (M) as an ideal candidate for orally administered colonic drug carriers. The kinetics and mechanism of drug release suggest that it follows a non-Fickian release mechanism.

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Acknowledgments

Authors earnestly acknowledge the financial support from the Department of Science and Technology, New Delhi, India, in the form of a research grant (no. SR/FT/CS-094/2009) to carry out the reported investigation.

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Authors and Affiliations

  1. Polymer Chemistry Laboratory, Department of Applied Chemistry, Indian School of Mines, Dhanbad, 826004, India

    Raghunath Das, Dipankar Das & Sagar Pal

  2. School of Medical Science and Technology, Indian Institute of Technology, Kharagpur, 721 302, India

    Paulomi Ghosh & Santanu Dhara

  3. Department of Pharmaceutical Sciences, Birla Institute of Technology, Mesra, 835215, Ranchi, India

    Animesh Ghosh

  4. Disciplines of Inorganic Materials and Catalysis, Central Salt and Marine Chemicals Research Institute (CSIR-CSMCRI), Bhavnagar, 364021, India

    A. B. Panda

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  1. Raghunath Das
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  2. Dipankar Das
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  3. Paulomi Ghosh
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  4. Animesh Ghosh
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Correspondence to Sagar Pal.

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Das, R., Das, D., Ghosh, P. et al. Novel pH-responsive graft copolymer based on HPMC and poly(acrylamide) synthesised by microwave irradiation: application in controlled release of ornidazole. Cellulose 22, 313–327 (2015). https://doi.org/10.1007/s10570-014-0511-0

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  • DOI: https://doi.org/10.1007/s10570-014-0511-0

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