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One-Pot Three-Component Synthesis of 2,3-Dihydroquinazolin-4(1H)-Ones in the Presence of a Molecular Sieve Supported Lanthanum Catalyst

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Abstract

A series of 2,3-dihydroquinazolin-4(1H)-ones have been synthesized with good to excellent yields by one-pot reaction using isatoic anhydride, aldehydes, and ammonium acetate or amines in acetonitrile in the presence of 4 Å molecular sieve modified with lanthanum(III) as an efficient heterogeneous catalyst. The catalyst could be reused without evident loss of activity.

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Acknowledgments

Á. M. is grateful to Chinoin Pharmaceuticals Ltd. for the financial support.

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Authors and Affiliations

  1. Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, Műegyetem rkp. 3., Budapest, 1111, Hungary

    Ágnes Magyar & Zoltán Hell

Authors
  1. Ágnes Magyar
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  2. Zoltán Hell
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Correspondence to Zoltán Hell.

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Magyar, Á., Hell, Z. One-Pot Three-Component Synthesis of 2,3-Dihydroquinazolin-4(1H)-Ones in the Presence of a Molecular Sieve Supported Lanthanum Catalyst. Catal Lett 146, 1153–1162 (2016). https://doi.org/10.1007/s10562-016-1734-5

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  • DOI: https://doi.org/10.1007/s10562-016-1734-5

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