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Imaging of early modification in cardiomyopathy: the doxorubicin-induced model

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Abstract

Doxorubicin chemotherapy is effective and widely used to treat acute lymphoblastic leukemia. However, its effectiveness is hampered by a wide spectrum of dose-dependent cardiotoxicity including both morphological and functional changes, affecting primarily the myocardium. Non-invasive imaging techniques are used for the diagnosis and monitoring of these cardiotoxic effects. The purpose of this review is to summarize and compare the most common imaging techniques used in early detection and therapeutic monitoring of doxorubicin-induced cardiotoxicity and the suggested mechanisms of such side effects. Imaging techniques using echocardiography including conventional 2D and 3D echocardiography along with MRI sequences including Tagging, Cine, and quantitative MRI in detecting early myocardial damage are also reviewed. As there is a multitude of reported indices and imaging methods to assess particular functional alterations, we limit this review to the most relevant techniques based on their clinical application and their potential to early detection of doxorubicin-induced cardiotoxic effects.

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Acknowledgments

This work was supported by The Cole Foundation, the Natural Sciences and Engineering Research Council (NSERC) of Canada and the MEDITIS training program (Ecole Polytechnique of Montreal and NSERC).

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Authors and Affiliations

  1. Mechanical Engineering Department, École Polytechnique de Montréal, Montreal, Canada

    Mohamed Aissiou & Delphine Périé

  2. Research Center Sainte-Justine University Hospital, Montreal, Canada

    Mohamed Aissiou, Delphine Périé, Farida Cheriet, Nagib S. Dahdah, Caroline Laverdière & Daniel Curnier

  3. Computer Engineering Department, École Polytechnique de Montréal, Montreal, Canada

    Farida Cheriet

  4. Kinesiology Department, University of Montreal, Montreal, Canada

    Daniel Curnier

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  1. Mohamed Aissiou
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Correspondence to Delphine Périé.

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Aissiou, M., Périé, D., Cheriet, F. et al. Imaging of early modification in cardiomyopathy: the doxorubicin-induced model. Int J Cardiovasc Imaging 29, 1459–1476 (2013). https://doi.org/10.1007/s10554-013-0248-0

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