Abstract
Background. African-American women (AAW) have more adverse tumor characteristics than non-African American women (non-AAW) and there is a need for a specific predictive marker for AAW recurrence. Tumors with higher grade and proliferative activity are associated with overexpression of the glucose transporter (Glut-1). An examination of Glut-1 expression relative to recurrence and no recurrence was conducted on both groups to determine if it predicts prognosis and could predict a race specific prognosis.
Methods. A breast cancer data set containing clinical information including race and biological characteristics was generated between 1991 and 1996. Tissue samples were selected from this group with similar characteristics in both racial groups for a retrospective analysis of Glut-1 expression using tissue microarrays (TMAs). Mean Glut-1 expression for intensity and percent of tumor cells staining was determined using standard immunohistochemistry.
Results. Clinical and biological differences were noted in the original data set between AAW and non-AAW. No significant difference between races was noted in mean Glut-1 values using a subset which had similar characteristics. The mean Glut-1 did not predict recurrence but a rounded score did indicate that higher levels of Glut-1 expression was indicative of a lower disease free survival (p = 0.063). The actual average mean for AAW with no recurrence was significantly lower than any other group (p = 0.04).
Conclusions. TMA analysis for Glut-1 expression may be useful to predict disease free survival but it does not predict race specific recurrence.
Similar content being viewed by others
References
R Chlebowski (2005) ArticleTitleEthnicity and breast cancer; Factors influencing differences in incidence and outcome J Natl Cancer Inst 97 IssueID6 439–447 Occurrence Handle15770008
InstitutionalAuthorNameACS (2003) Cancer facts and figures for African Americans: 2003–2004 American Cancer Society Atlanta
InstitutionalAuthorNameSEER (2003) Cancer Statistics Review, 1975–2000 National Cancer Institute Bethesda, MD
A Ghafoor A Jemal E Ward V Cokkinides P Smith M Thun (2003) ArticleTitleTrends in breast cancer by race and ethnicity CA Cancer J Clin 53 342–355 Occurrence Handle15224974
JG Elmore VM Moceri D Carter EB Larson (1998) ArticleTitleBreast carcinoma tumor characteristics in black and white women Cancer 83 2509–2515 Occurrence Handle10.1002/(SICI)1097-0142(19981215)83:12<2509::AID-CNCR15>3.0.CO;2-V Occurrence Handle9874456
CP Hunter CK Redmond VW Chen DF Austin RS Greenberg P Correa HB Muss MR Forman MN. Wesley RS. Blacklow RJ. Kurman JJ Dignam BK. Edwards S Shapiro (1993) ArticleTitleBreast Cancer: factors associated with stage at diagnosis in black and white women J Natl Cancer Inst 85 1129–1137 Occurrence Handle8320742
M Schootman DB Jeffe AH Reschke RL Aft (2003) ArticleTitleDisparities related to socioeconomic status and access to medical care remain in the United States among women who never had a mammogram Cancer Cause Control 14 IssueID5 7419–425
SA Joslyn (2002) ArticleTitleRacial differences in treatment and survival from early-stage breast carcinoma Cancer 95 1759–1766 Occurrence Handle10.1002/cncr.10827 Occurrence Handle12365025
CI Li KE Malone JR Daling (2002) ArticleTitleDifferences in breast cancer hormone receptor status and histology by race and ethnicity among women 50 years of age and older Cancer Epidemiol Biomarkers Prev 11 301–307
ET Liu (1998) ArticleTitleThe Uncoupling of Race and Cancer Genetics Supplement to Cancer 83 1765–1769
LP Middleton V Chen GH Perkins V Pinn D Page (2003) ArticleTitleHistopathology of breast cancer among African American women Cancer 97 253–257 Occurrence Handle10.1002/cncr.11021 Occurrence Handle12491489
BJ Trock (1996) ArticleTitleBreast cancer in African American women: epidemiology and tumor biology Breast Cancer Res Treat 40 11–24 Occurrence Handle10.1007/BF01805999 Occurrence Handle8888149
H Aziz F Hussain C Sohn R Mediavillo A Saitta A Hussain M Brands P Homel M Rotman (1999) ArticleTitleEarly onset of breast carcinoma in African American women with poor prognostic factors Am J Clin Oncol 22 436–440 Occurrence Handle10.1097/00000421-199910000-00002 Occurrence Handle10521053
M Dolled-Filhart RL Camp DP Kowalski BL Smith DL Rimm (2003) ArticleTitleTissue microarray analysis of signal transducers and activators of transcription 3 (Stat3) and phosphor-Stat3 (Tyr705) in node negative breast cancer shows nuclear localization is associated with a better prognosis Clin Cancer Res 9 594–600 Occurrence Handle12576423
JY Kang M Dolled-Filhart IT Ocal B Singh CY Lin RB Dickson DL Rimm RL Camp (2003) ArticleTitleTissue microarray analysis of hepatocyte growth factor/Met pathway components reveals a role for met, matriptase, and hepatocyte growth factor activator inhibitor 1 in the progression of node negative breast cancer Cancer Res 63 1101–1105 Occurrence Handle12615728
RL Camp M Dolled-Filhart BL King DL Rimm (2003) ArticleTitleQuantitative analysis of breast cancer tissue microarray shows that both high and normal levels of HER2 expression are associated with poor outcome Cancer Res 63 1445–1448 Occurrence Handle12670887
J Kononen L Bubendorf A Kallioniemi M Barlund P Schraml S Leighton J Torhorst MJ Mihatsch G Sauter OP Kallioniemi (1998) ArticleTitleTissue microarrays for high-throughput molecular Nat Med 4 844–847 Occurrence Handle10.1038/nm0798-844 Occurrence Handle9662379
RL Camp LA Charette DL Rimm (2000) ArticleTitleValidation of tissue microarray technology in breast carcinoma Lab Invest 80 1943–1949 Occurrence Handle11140706
CF Burant WI Sivitz H Fukumoto T Kayano S Magamatsu S Seino JE Pessin GI Bell (1991) ArticleTitleMammalian glucose transporters: structure and molecular regulation Recent Prog Horm Res 47 349–387 Occurrence Handle1745825
A Carruthers (1990) ArticleTitleFacilitated diffusion of glucose Physiol Rev 70 1135–1176 Occurrence Handle2217557
JE Pessin GI Bell (1992) ArticleTitleMammalian facilitative glucose transporter family: structure and molecular regulation Annu Rev Physiol 54 911–930 Occurrence Handle10.1146/annurev.ph.54.030192.004403 Occurrence Handle1562197
RA Medina GI Owen (2002) ArticleTitleGlucose transporters: expression, regulation Biol Res 35 IssueID1 9–26 Occurrence Handle12125211
SS Kang YK Chun MH Hur HK Lee YJ Kim SR Hong JH Lee SG Lee YK Park (2002) ArticleTitleClinical significance of glucose transporter 1 (GLUT1) expression in human breast carcinoma Jpn J Cancer Res Oct 93 IssueID10 1123–1128
SS Gambhir (2002) ArticleTitleMolecular imaging of cancer with positron emission tomography Nat Rev Cancer 2 683–693 Occurrence Handle10.1038/nrc882 Occurrence Handle12209157
RS Brown RL Wahl (1993) ArticleTitleOver expression of Glut-1 glucose transporter in human breast cancer. An immunohistochemical study Cancer 72 IssueID10 2979–2985 Occurrence Handle8221565
H Vesselle RA Schmidt JM Pugsley M Li SG Kohlmyer E Vallires DE Wood (2000) ArticleTitleLung cancer proliferation correlates with [F-18] fluorodeoxyglucose uptake by positron emission tomography Clin Cancer Res 6 3837–3844 Occurrence Handle11051227
AC Clavo RS Brown RL Wahl (1995) ArticleTitleFluorodeoxyglucose uptake in human cancer cell lines is increased by hypoxia J Nucl Med 36 1625–1632 Occurrence Handle7658223
R Bos JJ Hoeven Particlevan Der E Wall Particlevan Der P Groep Particlevan Der PJ Diest Particlevan EF Comans U Joshi GL Semenza OS Hoekstra AA Lammkertsma CF Molthoff (2002) ArticleTitleBiologic correlates of (18)fluorodeoxyglucose uptake in human breast cancer measured by positron emission tomography J Clin Oncol 20 379–387 Occurrence Handle10.1200/JCO.20.2.379 Occurrence Handle11786564
D Rivenzon-Segal S Boldin-Adamsky D Seger R Seger H Degani (2003) ArticleTitleGlycolysis and glucose transporter 1 as markers of response to hormonal therapy in breast cancer Int J Cancer 107 IssueID2 177–182 Occurrence Handle10.1002/ijc.11387 Occurrence Handle12949791
AL Folpe RH Lyles JT Sprouse EU Conrad JF Eary (2000) ArticleTitle[F-18] Flurodeoxyglucose positron emission tomography as a predictor of pathologic grade and other prognostic variables in bone and soft tissue sarcoma Clin Cancer Res 6 1279–1287 Occurrence Handle10778952
M Younes RW Brown DR Mody L Fernandez R Laucirica (1995) ArticleTitleGlut-1 expression in human breast carcinoma: Corellation with known prognostic markers Anticancer Res 15 IssueID6B 2895–2989 Occurrence Handle8669885
DE Henson KC Chu PH Levine (2003) ArticleTitleHistologic grade, stage, and survival in breast carcinoma. Comparison of African-American and Caucasian women Cancer 98 907–917
RM Elledge GM Clarke GC Chamness CK Osborne (1994) ArticleTitleTumor biologic factors and breast cancer prognosis among White, Hispanic and Black women in the United States J Natl Cancer Inst 86 705–712 Occurrence Handle7908990
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Stackhouse, B.L., Williams, H., Berry, P. et al. Measurement of Glut-1 Expression Using Tissue Microarrays to Determine a Race Specific Prognostic Marker for Breast Cancer. Breast Cancer Res Treat 93, 247–253 (2005). https://doi.org/10.1007/s10549-005-5158-y
Issue Date:
DOI: https://doi.org/10.1007/s10549-005-5158-y