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Two new dialkoxycarbonylated nucleosides obtained through a regioselective enzymatic alcoholysis

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Abstract

Two new compounds, 2′,3′-di-O-ethoxycarbonyluridine and 2′,3′-di-O-ethoxycarbonylinosine, were obtained through a Candida antarctica lipase B catalysed regioselective ethanolysis of the corresponding trialcoxycarbonylated nucleosides with benzyl alcohol in 1,4-dioxane at 30°C.

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Acknowledgements

We thank UNQ, CONICET, SECyT and CIC for partial financial support. LEI and AMI are research members of CONICET. We are grateful to Novozymes (Brazil) for the generous gift of CAL B.

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Authors and Affiliations

  1. Universidad Nacional de Quilmes, Roque Sáenz Peña 352, 1876, Bernal, The Province of Buenos Aires, Argentina

    Mariana Capello, Leandro Imanishi, Luis E. Iglesias & Adolfo M. Iribarren

  2. INGEBI (CONICET), Vuelta de Obligado 2490, 1428, Buenos Aires, Argentina

    Adolfo M. Iribarren

Authors
  1. Mariana Capello
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  2. Leandro Imanishi
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  3. Luis E. Iglesias
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  4. Adolfo M. Iribarren
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Corresponding author

Correspondence to Luis E. Iglesias.

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Capello, M., Imanishi, L., Iglesias, L.E. et al. Two new dialkoxycarbonylated nucleosides obtained through a regioselective enzymatic alcoholysis. Biotechnol Lett 29, 1217–1220 (2007). https://doi.org/10.1007/s10529-007-9374-x

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  • DOI: https://doi.org/10.1007/s10529-007-9374-x

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