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Targeted Delivery of Cisplatin by Сonnexin 43 Vector Nanogels to the Focus of Experimental Glioma C6

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Bulletin of Experimental Biology and Medicine Aims and scope

The aim of this study was to create a nanocontainer conjugated with monoclonal antibodies to connexin 43 (Cx43) that is actively expressed at the periphery of C6 glioma and in the astroglia roll zone. Stable vector nanogels with high (up to 35%) cisplatin load were synthesized. The antitumor effects of Cx43-modified cisplatin-loaded nanogels, free cisplatin, and nonspecific drugs were carried out on C6 glioma model. Vector nanogels reduced systemic toxicity of cisplatin, effectively inhibited tumor growth, and significantly prolonged the lifespan of animals with experimental tumors.

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Authors and Affiliations

  1. Department of Basic and Applied Neurobiology, V. P. Serbsky State Research Center of Social and Forensic Psychiatry, Ministry of Health of the Russian Federation, Moscow, Russia

    V. P. Baklaushev, T. O. Abakumova, M. A. Abakumov, G. M. Yusubalieva & V. P. Chekhonin

  2. Department of Medical Nanobiotechnologies, Biomedical Faculty, N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation, Moscow, Russia

    N. V. Nukolova, V. P. Baklaushev, P. A. Mel’nikov & V. P. Chekhonin

  3. Department of Chemical Enzymology, Chemical Faculty, Moscow, Russia

    N. V. Nukolova, T. O. Abakumova, M. A. Abakumov & A. V. Kabanov

  4. Geological Faculty, M. V. Lomonosov Moscow State University, Moscow, Russia

    D. A. Bychkov

  5. Department of Molecular Pharmacology, Pharmaceutical Division, University of North Carolina, Chapel-Hill, USA

    A. V. Kabanov

Authors
  1. N. V. Nukolova
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  2. V. P. Baklaushev
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  3. T. O. Abakumova
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  4. P. A. Mel’nikov
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  5. M. A. Abakumov
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  6. G. M. Yusubalieva
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  7. D. A. Bychkov
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  8. A. V. Kabanov
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  9. V. P. Chekhonin
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Corresponding author

Correspondence to N. V. Nukolova.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 157, No. 4, pp. 527-533, April, 2014

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Nukolova, N.V., Baklaushev, V.P., Abakumova, T.O. et al. Targeted Delivery of Cisplatin by Сonnexin 43 Vector Nanogels to the Focus of Experimental Glioma C6. Bull Exp Biol Med 157, 524–529 (2014). https://doi.org/10.1007/s10517-014-2606-x

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  • DOI: https://doi.org/10.1007/s10517-014-2606-x

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