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Expression of Peroxiredoxin 1, 2, 3, and 6 Genes in Cancer Cells during Drug Resistance Formation

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We studied the expression of peroxiredoxin genes (PRDX1, PRDX2, PRDX3, and PRDX6) in human erythroleukemia K652, human breast carcinoma MCF-7, and human ovarian carcinoma SKOV-3 cells during cisplatin resistance development. It was found that drug resistance formation was accompanied by a significant increase in the expression of PRDX1, PRDX2, PRDX3, PRDX6 genes in all cancer cell strains, which confirms the important contribution of redox-dependent mechanisms into the development of cisplatin resistance of cancer cells.

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Authors and Affiliations

  1. People’s Friendship University of Russia, Moscow, Russia

    E. V. Kalinina, T. T. Berezov, N. N. Chernov, M. D. Novichkova & N. K. Nurmuradov

  2. N. N. Blokhin Cancer Research Center, Russian Academy of Medical Sciences, Moscow, Russia

    A. A. Shtil’ & V. A. Glazunova

Authors
  1. E. V. Kalinina
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  2. T. T. Berezov
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  3. A. A. Shtil’
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  4. N. N. Chernov
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  5. V. A. Glazunova
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  6. M. D. Novichkova
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  7. N. K. Nurmuradov
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Corresponding author

Correspondence to E. V. Kalinina.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 153, No. 6, pp. 861-864, June, 2012

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Kalinina, E.V., Berezov, T.T., Shtil’, A.A. et al. Expression of Peroxiredoxin 1, 2, 3, and 6 Genes in Cancer Cells during Drug Resistance Formation. Bull Exp Biol Med 153, 879–882 (2012). https://doi.org/10.1007/s10517-012-1849-7

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  • DOI: https://doi.org/10.1007/s10517-012-1849-7

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