Skip to main content
Log in

Chitosan-based polyelectrolyte complexes: A review

  • Published:
Applied Biochemistry and Microbiology Aims and scope Submit manuscript

Abstract

This review focuses on the formation of polyelectrolyte chitosan complexes with biologically active compounds and the prospects of use thereof. The possibility of obtaining low-molecular-weight, water-soluble batches of chitosan, which differ in their degree of acetylation, is discussed, with emphasis on their use for binding nucleic acids into complexes.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

REFERENCES

  1. K.A. Janes P. Calvo M.J. Alonso (2001) Adv. Drug. Deliv. Rev. 47 IssueID1 83–97

    Google Scholar 

  2. M. Mochizuki Y. Kadoya Y. Wakabayashi K. Kato I. Okazaki M. Yamada T. Sato N. Sakaira N. Nishi M. Nomizu (2003) FASER J. 17 IssueID8 875–877

    Google Scholar 

  3. J. Berger M. Reist J.M. Mayer O. Felt N.A. Peppas R. Gurny (2004) Eur. J. Pharm. Biopharm. 57 IssueID1 19–34

    Google Scholar 

  4. T. Cerchiara B. Luppi F. Bigucci I. Orienti V. Zecchi (2002) J. Pharm. Pharmacol. 54 IssueID11 1453–1459

    Google Scholar 

  5. H.P. Brack S.A. Tirmizi W.M. Risen (1997) Polymer 38 IssueID10 2351–2362

    Google Scholar 

  6. F.I. Mi S.S. Shyu T.B. Wong S.F. Jang S.T. Lee K.T. Lu (1999) J. Appl. Polym. Sci. 74 IssueID5 1093–1107

    Google Scholar 

  7. A. Chenite M. Buschmann D. Wang C. Chaput N. Kandani (2001) Carbohydr. Res. 46 IssueID1 39–47

    Google Scholar 

  8. J. Li Z. Xu (2002) J. Pharm. Sci. 91 IssueID7 1669–1677

    Google Scholar 

  9. L. Noble A.I. Gray L. Sadiq I.F. Uchegbu (1999) Int. J. Pharm. 192 IssueID2 173–182

    Google Scholar 

  10. J. Berger M. Reist J.M. Mayer O. Felt R. Gurny (2004) Eur. J. Pharm. Biopharm. 57 IssueID1 35–52

    Google Scholar 

  11. S. Sabnis L.H. Block (2000) Int. J. Biol. Macromol. 27 IssueID3 181–186

    Google Scholar 

  12. Y.H. Kim S.H. Gihm C.R. Park K.Y. Lee T.W. Kim I.C. Know H. Chung S.Y. Jeong (2001) Bioconjug. Chem. 12 IssueID6 932–938

    Google Scholar 

  13. F.C. MacLaughlin R.J. Mumper J. Wang J.M. Tagliaferri I. Gill M. Hinchcliffe A.P. Rolland (1998) J. Control. Release 56 IssueID1–3 259–272

    Google Scholar 

  14. T.H. Kim J.E. Ihm Y.J. Choi J.W. Nah C.S. Cho (2003) J. Control. Release 93 IssueID3 389–402

    Google Scholar 

  15. Yu.M. Evdokimov V.I. Salyanov S.V. Semenov A.V. Il’ina V.P. Varlamov (2002) Izv. Akad. Nauk SSSR, Ser.: Biol. 36 IssueID2 532–541

    Google Scholar 

  16. Yu.M. Evdokimov (2002) NoChapterTitle K.G Skryabin G.A Vikhoreva V.P. Varlamov (Eds) Khitin i khitozan Nauka Moscow

    Google Scholar 

  17. G.E. Fredheim B.E. Christensen (2003) Biomacromolecules 4 IssueID2 232–239

    Google Scholar 

  18. A.K. Singla M. Chawla (2003) J. Pharm. Pharmacol. 53 IssueID8 1047–1067

    Google Scholar 

  19. C. Tapia Z. Escobar E. Costa J. Sapag-Hagar F. Valenzuela C. Basualto G.M. Nella M. Yazdani-Pedram (2004) Eur. J. Pharm. Biopharm. 57 IssueID1 65–75

    Google Scholar 

  20. P. Murra N. Zerrouk N. Mennini F. Maestrelli C. Chemtob (2003) Eur. J. Pharm. Sci. 19 IssueID1 67–75

    Google Scholar 

  21. S. Murdan (2003) J. Control. Release 92 IssueID1–2 1–17

    Google Scholar 

  22. A. Vila A. Sanchez K. Janes I. Behrens T. Kissel J.L. Vila-Jato M.J. Alonso (2004) Eur. J. Pharm. Biopharm. 57 IssueID1 123–131

    Google Scholar 

  23. L. Illum I. Jabbal-Gill M. Hinchcliffe A.N. Fisher S.S. Daviss (2001) Adv. Drug. Deliv. Rev. 51 IssueID1–3 81–96

    Google Scholar 

  24. A.M. Dyer M. Hinchcliffe P. Watts J. Castile I. Jabbal-Gill R. Nankervis A. Smith L. Illum (2002) Pharm. Res 19 IssueID7 998–1008

    Google Scholar 

  25. G. Borchard (2001) Adv. Drug. Deliv. Rev. 52 IssueID2 145–150

    Google Scholar 

  26. H. Okamoto S. Nishida H. Todo Y. Sakakura K. Iida K. Danjo (2003) J. Pharm. Sci. 92 IssueID2 371–380

    Google Scholar 

  27. M. Thanou Bi. Florea M. Geldof H.E. Junginger G. Borchard (2002) Biomaterials 23 IssueID1 153–159

    Google Scholar 

  28. T. Nagasaki M. Hojo A. Uno T. Satch K. Koumoto M. Mizu K. Sakurai S. Shinkai (2004) Bioconjug. Chem. 15 IssueID2 249–259

    Google Scholar 

  29. P. Erbacher S. Zou T. Bettinger A.M. Steffan J.S. Remy (1998) Pharm. Res. 15 IssueID9 1332–1339

    Google Scholar 

  30. H. Sashiwa J.M. Thompson S.K. Das Y. Shigemasa S. Tripathy R Roy (2000) Biomacromolecules 1 IssueID3 303–305

    Google Scholar 

  31. A. Sharma K. Mondal M.N. Gupta (2003) J. Chromatogr., A 995 IssueID1–2 127–134

    Google Scholar 

  32. C. Sasaki A. Kristiansen T. Fukamizo K.M. Varum (2003) Biomacromolecules 4 IssueID6 1686–1690

    Google Scholar 

  33. S.I. Park Y. Zhao (2004) J. Agric. Food Chem. 52 IssueID7 1933–1939

    Google Scholar 

  34. X.Z. Shu K.L. Zhu W. Song (2001) Int. J. Pharm. 212 IssueID1 19–28

    Google Scholar 

  35. K. Kofuji H. Akamine C.J. Qian K. Watanaba Y. Togan M. Nishimura I. Sugiyama Y. Murata S. Kawashima (2004) Int. J. Pharm. 272 IssueID1–2 65–78

    Google Scholar 

  36. E. Ruel-Gariepy A. Chenite C. Chaput S. Guirguis J. Lerous (2000) Int. J. Pharm. 203 IssueID1–2 89–98

    Google Scholar 

  37. S. Ramanathan L.H. Block (2001) J. Control. Release 70 IssueID1–2 109–123

    Google Scholar 

  38. S.V. Vinogradov T.K. Bronich A.V. Kabanov (2002) Adv. Drug. Deliv. Rev. 54 IssueID1 135–147

    Google Scholar 

  39. M. Koping-Hoggard I. Tubulekas H. Guan K. Edwards M. Nilsson K.M. Varum P. Artursson (2001) Gene Ther 8 IssueID14 1108–1121

    Google Scholar 

  40. J. Luten J.H. Steenis R. Someren J. Kemmink N.M. Schuurmans-Nieuwenbroek G.A. Koning D.J. Crommelin C.F. Nostrum W.E. Hennink (2003) J. Control. Release 89 IssueID3 483–497

    Google Scholar 

  41. S.C. Smedt J. Demeester W.E. Hennink (2000) Pharm. Res. 17 IssueID2 113–126

    Google Scholar 

  42. T. Sato T. Ishii Y. Okahata (2001) Biomaterials 22 IssueID15 2075–2080

    Google Scholar 

  43. S. Mansouri P. Lavigne K. Corsi M. Benderdour E. Beaumont J.C. Fernandes (2004) Eur. J. Pharm. Biopharm. 57 IssueID1 1–8

    Google Scholar 

  44. H.Q. Mao K. Roy V.L. Troung-Le K.Y. Lin Y. Wang J.T. August K.W. Leong (2001) J. Control. Release 70 IssueID3 399–421

    Google Scholar 

  45. S. Richardson H. Kolbe R. Duncan (1999) Inter. J. Pharmaceutics 178 IssueID2 231–243

    Google Scholar 

  46. M. Koping-Hoggard Y.S. Mel’nikova K.M. Varum B. Lindman P. Artursson (2003) J. Gene Med. 5 IssueID2 130–141

    Google Scholar 

  47. F. Yang X. Cui X. Yang (2002) Biophys. Chem. 99 IssueID1 99–106

    Google Scholar 

  48. T. Ishii Y. Okahata T. Sato (2001) Biochim. Biophys. Acta 1514 IssueID1 51–64

    Google Scholar 

  49. W.G. Liu X. Zhang S.J. Sun G.J. Sun K.D. Yao D.C. Liang G. Guo J.Y. Zhang (2003) Bioconjug. Chem. 14 IssueID4 782–789

    Google Scholar 

  50. S. Gao J. Chen X. Xu Z. Ding Y.H. Yang Z. Hua J. Zhang (2003) Int. J. Pharm. 255 IssueID1–2 57–68

    Google Scholar 

  51. I.K. Park T.H. Kim S.E. Kim Y.H. Park W.J. Kim T. Akaike C.S. Cho (2003) Int. J. Pharm. 257 IssueID1–2 103–110

    Google Scholar 

  52. A. Gutowska B. Jeong M. Jasionowski (2001) Anat. Rec. 263 IssueID4 342–349

    Google Scholar 

  53. J.S. Mao L.G. Zhao Y.J. Yin K.D. Yao (2003) Biomaterials 24 IssueID6 1067–1074

    Google Scholar 

  54. J.K. Sun H.W. Matthew (2000) Biomaterials 21 IssueID24 2589–2598

    Google Scholar 

  55. S.V. Madihally H.W. Matthew (1999) Biomaterials 20 IssueID12 1133–1142

    Google Scholar 

  56. A. Denuziere D. Ferrier A. Domard (2000) Ann. Pharm. Fr. 58 IssueID1 47–53

    Google Scholar 

  57. M. Kuberka I. Heschel B. Glasmacher G. Rau (2002) Biomed. Tech. 47 IssueID1 485–487

    Google Scholar 

  58. C. Chatelet O. Damour A. Domard (2001) Biomaterials 22 IssueID3 261–268

    Google Scholar 

  59. D.-K. Kweon S.-B. Song Y.-Y. Park (2003) Biomaterials 24 IssueID9 1595–1601

    Google Scholar 

  60. C.-C. Tsai Y. Chang H.-W. Sung J.-Ch. Hsu Ch.-N. Chen (2001) Biomaterials 22 IssueID6 523–533

    Google Scholar 

  61. W.C. Lin T.Y. Liu M.C. Yang (2004) Biomaterials 25 IssueID10 1947–1957

    Google Scholar 

  62. G. Berth A. Voigt H. Dautzenberg E. Donath H. Mohwald (2002) Biomacromolecules 3 IssueID3 579–590

    Google Scholar 

  63. X.L. Yan E. Khor L.Y. Lim (2001) J. Biomed. Mater. Res 58 IssueID4 358–365

    Google Scholar 

  64. V.N. Davidova I.M. Yermak V.I. Gorbach T.F. Soloveva (1999) Membr. Cell Biol. 13 IssueID1 49–58

    Google Scholar 

  65. V.N. Davydova I.M. Ermak V.I. Gorbach I.N. Krasikova T.F. Solov’eva (2000) Biokhimiya 65 IssueID9 1278–1287

    Google Scholar 

  66. S.S. Betigeri S.H. Neau (2002) Biomaterials 23 IssueID17 3627–3636

    Google Scholar 

  67. I.A. Alsarra S.S. Betigeri H. Zhang B.A. Evans S.H. Neau (2002) Biomaterials 23 IssueID17 3637–3644

    Google Scholar 

  68. D. Magnin S. Dumitriu P. Magny E. Chornet (2001) Biotechnol. Prog. 17 IssueID4 734–737

    Google Scholar 

  69. P. Sorlier A. Denuziere C. Viton A. Domard (2001) Biomacromolecules 2 IssueID3 765–772

    Google Scholar 

  70. C. Schatz C. Viton T. Delair C. Pichot A. Domard (2003) Biomacromolecules 4 IssueID3 641–648

    Google Scholar 

  71. P. Sorlier C. Viton A. Domard (2002) Biomacromolecules 3 IssueID6 1336–1342

    Google Scholar 

  72. O. Philippova E. Volkov N. Sitnikova A. Khokhlov (2001) Biomacromolecules 2 IssueID2 483–490

    Google Scholar 

  73. G.J. Tsai S.L. Zhang P.L. Shieh (2004) J. Food Prot. 67 IssueID2 396–398

    Google Scholar 

  74. A.B. Kumar L.R. Gowda R.N. Tharanathan (2004) Eur. J. Biochem. 271 IssueID4 713–723

    Google Scholar 

  75. F.S. Kittur A.B. Vishu-Kumar R.N. Tharanathan (2003) Carbohydr. Res. 338 IssueID12 1283–1290

    Google Scholar 

  76. A.B. Vishu-Kumar M.C. Varadaraj R.G. Lalitha R.N. Tharanathan (2004) Biochim. Biophys. Acta 1670 IssueID2 137–146

    Google Scholar 

  77. A.V. Ilyina N.Yu. Tatarinova V.P. Varlamov (1999) Proc. Biochem. Soc. 34 IssueID9 875–878

    Google Scholar 

  78. A.V. Ilyina V.E. Tikhonov A.I. Albulov V.P. Varlamov (2000) Proc. Biochem. Soc. 35 IssueID6 563–568

    Google Scholar 

  79. A.V. Ilyina V.P. Varlamov L.A. Gabdrakhmanova D.V. Yusupova A.I. Albulov (2001) NoChapterTitle H. Struszczyk (Eds) Progress on Chemistry and Application of Chitin and its Derivatives Polish Chitin Soc. Lodz 57–63

    Google Scholar 

  80. A.V. Il’ina V.P. Varlamov A.I. Melent’ev G.E. Aktuganov (2001) Prikl. Biokhim. Mikrobiol. 37 IssueID2 160–163

    Google Scholar 

  81. A.V. Il’ina Yu.V. Tkacheva V.P. Varlamov (2002) Prikl. Biokhim. Mikrobiol. 38 IssueID2 132–135

    Google Scholar 

  82. A.V. Il’ina V.P. Varlamov (2003) Prikl. Biokhim. Mikrobiol. 39 IssueID3 273–277

    Google Scholar 

  83. V.I. Salyanov A.V. Il’ina V.P. Varlamov Yu.M. Evdokimov (2002) Izv. Akad. Nauk SSSR, Ser.: Biol. 36 IssueID4 699–705

    Google Scholar 

  84. Yu.M. Evdokimov V.I. Salyanov S.G. Skuridin A.T. Dembo (2002) Izv. Akad. Nauk SSSR, Ser.: Biol. 36 IssueID4 706–714

    Google Scholar 

  85. Yu.M. Yevdokimov V.I. Salyanov (2003) Liq. Cryst. 30 IssueID9 1057–1074

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Additional information

Translated from Prikladnaya Biokhimiya i Mikrobiologiya, Vol. 41, No. 1, 2005, pp. 9–16.

Original Russian Text Copyright © 2005 by Il’ina, Varlamov.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Il’ina, A.V., Varlamov, V.P. Chitosan-based polyelectrolyte complexes: A review. Appl Biochem Microbiol 41, 5–11 (2005). https://doi.org/10.1007/s10438-005-0002-z

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10438-005-0002-z

Keywords

Navigation