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The microbiome, HLA, and the pathogenesis of uveitis

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Abstract

An understanding of the microbiome is emerging as an exciting and novel way to elucidate the regulation of the immune system. Since the immune system plays a major role in the pathogenesis of many diseases including most forms of uveitis, it is critical to clarify the relationship between our immune system and the commensal bacteria that coexist in every human being.

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Acknowledgments

NIH grant K08 EY022948 to PL; the Collins Medical Foundation; Medical Research Foundation of Oregon; the William and Mary Bauman Foundation; the Stan and Madelle Rosenfeld Family Trust; the Spondylitis Association of America.

Conflicts of interest

J. T. Rosenbaum, None; P. Lin, None; M. Asquith, None.

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Authors and Affiliations

  1. Casey Eye Institute, Oregon Health and Science University, 3375 S.W. Terwilliger Blvd., Portland, OR, 97239, USA

    James T. Rosenbaum & Phoebe Lin

  2. Legacy Devers Eye Institute, Portland, OR, 97210, USA

    James T. Rosenbaum

  3. Department of Medicine, Oregon Health and Science University, Portland, OR, 97239, USA

    Mark Asquith

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  1. James T. Rosenbaum
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  2. Phoebe Lin
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Correspondence to James T. Rosenbaum.

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Rosenbaum, J.T., Lin, P. & Asquith, M. The microbiome, HLA, and the pathogenesis of uveitis. Jpn J Ophthalmol 60, 1–6 (2016). https://doi.org/10.1007/s10384-015-0416-y

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