Abstract
Purpose
To investigate the risk factors for primary open-angle glaucoma (POAG) in the Namil study population.
Methods
A cross-sectional, population-based epidemiological study of residents aged ≥40 years from Namil-myon, South Korea, was conducted. Fifty-five subjects with POAG and 1,409 controls were enrolled in this study. Univariate and multivariate logistic regression analyses were performed to identify ocular and systemic factors associated with POAG.
Results
Multivariate logistic regression analysis demonstrated that older age, a history of thyroid disease and higher IOP were associated with an increased risk of POAG. Subgroup analysis showed that older age (OR 1.033, 95 % CI 1.003–1.063 per year), a history of thyroid disease (OR 7.373, 95 % CI 1.407–38.636) and higher IOP (OR 1.132, 95 % CI 1.011–1.268 per mmHg) were risk factors for normal tension glaucoma (NTG, POAG with IOP ≤21 mmHg).
Conclusions
In the Namil study, higher IOP, older age and a history of thyroid disease were significant risk factors for POAG.
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Acknowledgments
The authors thank Soo Hee Kang, Medical Research Collaborating Center, Seoul National University Hospital, for assistance with statistical analysis. This study was supported by Alcon Korea, Merck Korea, Pfizer Korea, Taejoon Pharmaceutical, Zeiss Korea and the Korean Ophthalmological Society.
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For the Namil Study Group, the Korean Glaucoma Society.
The members of Namil Study Group, the Korean Glaucoma Society, are given in the Appendix.
Appendix
Appendix
The Namil Study Group, Korean Glaucoma Society:
Byung-Heon Ahn, MD, PhD, Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine
Myung Douk Ahn, MD, PhD, Department of Ophthalmology, College of Medicine, The Catholic University of Korea
Nam Ho Baek, MD, PhD, Saevit Eye Hospital
Kyu-Ryong Choi, MD, PhD, Department of Ophthalmology, Ewha Womans University School of Medicine
Seung-Joo Ha, MD, Department of Ophthalmology, Soonchunhyang University, College of Medicine
Gyu-Heon Han, MD, PhD, Doctor Lee’s Eye Clinic
Young Jae Hong, MD, PhD, Nune Eye Hospital
Ja-Heon Kang, MD, PhD, Department of Ophthalmology, Kyung Hee University College of Medicine
Changwon Kee, MD, PhD, Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine
Hong-Seok Kee, MD, PhD, Leeyeon Eye Clinic
Chan Yun Kim, MD, PhD, Department of Ophthalmology, Yonsei University College of Medicine
Chang-Sik Kim, MD, PhD, Department of Ophthalmology, College of Medicine, Chungnam National University
Hwang-Ki Kim, MD, Department of Ophthalmology, Konyang University College of Medicine, Kim’s Eye Hospital
Joon Mo Kim, MD, Department of Ophthalmology, Sungkyunkwan University School of Medicine, Kangbuk Samsung Hospital
Seok-Hwan Kim, MD, PhD, Department of Ophthalmology, Seoul National University College of Medicine
Tae-Woo Kim, MD, PhD, Department of Ophthalmology, Seoul National University College of Medicine
Yong Yeon Kim, MD, PhD, Department of Ophthalmology, Korea University College of Medicine
Michael Scott Kook, MD, Department of Ophthalmology, University of Ulsan, College of Medicine, Asan Medical Center
Joo Hwa Lee, MD, PhD, Department of Ophthalmology, Sanggye-Paik Hospital, Inje University College of Medicine
Kyung-Wha Lee, MD, PhD, Department of Ophthalmology, Hallym University College of Medicine
Seung-Hyuck Lee, MD, PhD, Yonsei Plus Eye Center
Jung-Il Moon, MD, PhD, Department of Ophthalmology, College of Medicine, The Catholic University of Korea
Chan Kee Park, MD, PhD, Department of Ophthalmology, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea
Hyun Joon Park, MD, Merit Eye Clinic
Ki Ho Park, MD, PhD, Department of Ophthalmology, Seoul National University College of Medicine
Gong Je Seong, MD, PhD, Department of Ophthalmology, Yonsei University College of Medicine
Yong Ho Sohn, MD, PhD, Department of Ophthalmology, Konyang University College of Medicine, Kim’s Eye Hospital
Ki-Bang Uhm, MD, PhD, Department of Ophthalmology, Hanyang University College of Medicine
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Kim, M., Kim, TW., Park, K.H. et al. Risk factors for primary open-angle glaucoma in South Korea: the Namil study. Jpn J Ophthalmol 56, 324–329 (2012). https://doi.org/10.1007/s10384-012-0153-4
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DOI: https://doi.org/10.1007/s10384-012-0153-4