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Adverse effect of heavy metals (As, Pb, Hg, and Cr) on health and their bioremediation strategies: a review

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Abstract

Currently, heavy metal pollution becomes a severe problem whole over the world, and these toxic metals enter into the environment either by natural phenomena or due to extensive industrialization. The discharged effluents containing toxic heavy metals mixed with soil/water and change their natural composition. These heavy metals have adverse effects on living beings and cause damage to the vital body organs of animals as well as humans. The heavy metal pollution also inhibits the biodegradation of the chlorinated organic compounds (another type of environmental pollution) by interacting with metabolizing enzymes and inhibits their functioning. Earlier studies described that heavy metals cannot be fully removed from the environment, but they can be effectively neutralized or transformed into less toxic form so that their harmful effect on the environment can be reduced. The distinctive enzymatic apparatus within microbial system plays a major role in the transformation of heavy metals in the environment. A considerable advancement has been made during recent years to transform the heavy metals by utilizing the bioremediation potential of genetically engineered (GE) microorganisms. These transgenics are very much efficient in heavy metal transformations and still, we have to discover more to additionally utilize their full biotransformation potential.

In the present review article, the detailed description of the adverse effects of four heavy metals (arsenic, lead, mercury, and chromium) and their adverse effect on our environment and human beings is discussed. Furthermore, the use of microorganisms/GE organisms for the bioremediation of heavy metals from the environment is also discussed along with their detailed bioremediation mechanism.

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References

  • Ackerley DF, Gonzalez CF, Keyhan M, Blake R 2nd, Matin A (2004) Mechanism of chromate reduction by the Escherichia coli protein, NfsA, and the role of different chromate reductases in minimizing oxidative stress during chromate reduction. Environ Microbiol 6:851–860

    Article  PubMed  CAS  Google Scholar 

  • Ahmed E, Holmstrom SJM (2014) Siderophores in environmental research: roles and applications. Microbial Biotechnol 7:196–208

    Article  CAS  Google Scholar 

  • Aryal M, Liakopoulou-Kyriakides M (2015) Bioremoval of heavy metals by bacterial biomass. Environ Monit Assess 187(4173):1–26

    CAS  Google Scholar 

  • Ayangbenro AS, Babalola OO (2017) A new strategy for heavy metal polluted environments: a review of microbial biosorbents. Int J Environ Res Public Health 14(1):94

    Article  PubMed Central  CAS  Google Scholar 

  • Azimi S, Moghaddam MS (2013) Effect of mercury pollution on the urban environment and human health. Environ Ecology Res 1(1):12–20

    Google Scholar 

  • Azimi A, Azri A, Rezkazemi M, Ansarpour M (2017) Removal of heavy metals from industrial wastewaters: a review. Chem Bio Eng Reviews 4:37–59

    CAS  Google Scholar 

  • Azubuike CC, Chikere CB, Okpokwasili GC (2016) Bioremediation techniques—classification based on site of application: principles, advantages, limitations and prospects. World J Microbiol Biotechnol 32(11):180

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Bhalerao SA, Sharma AS (2015) Chromium: as an environmental pollutant. Int J Curr Microbiol App Sci 4(4):732–746

    CAS  Google Scholar 

  • Bondarenko O, Rolova T, Kahru A, Ivask A et al (2008) Bioavailability of Cd, Zn and Hg in soil to nine recombinant luminescent metal sensor bacteria. Sensors 8:6899–6923

    Article  PubMed  CAS  Google Scholar 

  • Bräuner EV, Nordsborg RB, Andersen ZJ, Tjønneland A, Loft S, Raaschou-Nielsen O (2014) Long-term exposure to low-level arsenic in drinking water and diabetes incidence: a prospective study of the diet, cancer and health cohort. Environ Health Perspect 122:1059–1065

    Article  PubMed  PubMed Central  Google Scholar 

  • Chen H, Wang L (2017) Chapter 5—microbial cell refining for biomass conversion. Technologies for Biochemical Conversion of Biomass 101–135

  • Cheyns K, Waegeneers N, de Wiele TV, Ruttens A (2017) Arsenic release from food stuffs upon food preparation. J Agri Food Chem 65(11):2443–2453

    Article  CAS  Google Scholar 

  • Chibuike GU, Obiora SC (2014) Heavy metal polluted soils: effect on plants and bioremediation methods. Applied and Environmental Soil Science Article ID 752708: 1–12

  • Cumberland SA, Douglas G, Grice K, Moreau JW (2016) Uranium mobility in organic matter-rich sediments: a review of geological and geochemical processes. Earth Sci Rev 159:160–185

    Article  CAS  Google Scholar 

  • Das S, Raj R, Mangwani N, Dash HR, Chakraborty J (2014) 2-heavy metals and hydrocarbons: adverse effects and mechanism of toxicity. Microbial Biodegradation and Bioremediation 23–54

  • Davidson A, Ryman J, Sutherland CA, Milner EF, Kerby RC, Teindl H, Melin A, Bolt HM (2014) Lead. Ullmann’s Encyclopedia of Industrial Chemistry doi:https://doi.org/10.1002/14356007.a15_193,

  • Deng X, Li QB, Lu YH, He N, Jiang J (2005) Genetic engineering of Escherichia coli SE5000 and its potential for Ni2+ bioremediation. Process Biochem 40:425–430

    Article  CAS  Google Scholar 

  • Dey U, Chatterjee S, Mondal NK (2016) Isolation and characterization of arsenic-resistant bacteria and possible application in bioremediation. Biotechnol Rep 10:1–7

    Article  Google Scholar 

  • Dixit R, Wasiullah, Malaviya D, Pandiyan K, Singh UB, Sahu A, Shukla R, Singh BP, Rai JP, Sharma PK, Lade H, Paul D (2015) Bioremediation of heavy metals from soil and aquatic environment: an overview of principles and criteria of fundamental processes. Sustainability 7(2):2189–2212

    Article  CAS  Google Scholar 

  • Driscoll CT, Mason RP, Chan HM, Jacob DJ, Pirrone N (2013) Mercury as a global pollutant: sources, pathways, and effects. Environ Sci Technol 47:4967–4983

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Ehrlich HL, Newman DK (2008) Geomicrobiology. CRC Press. 265, Geomicrobiology of Mercury

  • Ertani A, Mietto A, Borin M, Nardi S (2017) Chromium in agricultural soils and crops: a review. Water Air Soil Pollut 228:190

    Article  CAS  Google Scholar 

  • Freeman JL, Persans MW, Nieman K, Salt DE (2005) Nickel and cobalt resistance engineered in Escherichia coli by over expression of serine acetyl transferase from the nickel hyper accumulator plant Thlaspi goesingense. Appl Environ Microbiol 71:8627–8633

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Govind M (2014) Heavy metals causing toxicity in animals and fishes. Res J Animal Veterinary and Fishery Sci 2(2):17–23

    Google Scholar 

  • Gupta S, Singh D (2017) Role of genetically modified microorganisms in heavy metal bioremediation. Springer Nature Singapore Pvt. Ltd. R. Kumar et al. (eds.), Advances in environmental biotechnology DOI https://doi.org/10.1007/978-981-10-4041-2_12

  • Hansda A, Kumar V, Anshumali V, Usmani Z (2014) Phytoremediation of heavy metals contaminated soil using plant growth promoting rhizobacteria (PGPR): a current perspective. Recent Res in Sci & Tech 6(1):131–134

    Google Scholar 

  • Hasin AA, Gurman SJ, Murphy LM, Perry A, Smith TJ, Gardiner PE (2010) Remediation of chromium (VI) by a methane-oxidizing bacterium. Environ Sci Technol 44:400–405

    Article  PubMed  CAS  Google Scholar 

  • Ivask A, Dubourguier HC, Pollumaa L, Kahru A (2011) Bioavailability of Cd in 110 polluted top soils to recombinant bioluminescent sensor bacteria: effect of soil particulate matter. J Soils Sediments 11:231–237

    Article  CAS  Google Scholar 

  • Jebara SH, Abdelkerim S, Fatnassi IC, Chiboub M, Saadani O, Jebara M (2015) Identification of effective Pb resistant bacteria isolated from Lens culinaris growing in lead-contaminated soils. J Basic Microbiol 55:346–353

    Article  PubMed  CAS  Google Scholar 

  • Joshi PK, Swarup A, Maheshwari S, Kumar R, Singh N (2011) Bioremediation of heavy metals in liquid media through fungi isolated from contaminated sources. Indian J Microbiol 51:482–487

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Jouety NT, Sayel H, Bahafid W, El Ghachtouii N (2015) Mechanisms of hexavalent chromium resistance and removal by microorganisms. Rev Environ Contam Toxicol 233:45–69

    Google Scholar 

  • Khan A, Singh P, Srivastava A (2017) Synthesis, nature and utility of universal iron chelator–Siderophore: a review. Microbiol Res, in press 212-213:103–111. https://doi.org/10.1016/j.micres.2017.10.012

    Article  PubMed  CAS  Google Scholar 

  • Khatri N, Tyagi S (2015) Influences of natural and anthropogenic factors on the surface and groundwater quality in rural and urban areas. Front Life Sci 8(1):23–39

    Article  CAS  Google Scholar 

  • Kiyono M, Pan-Hou H (2006) Genetic engineering of bacteria for environmental remediation of mercury. J Health Sci 52:199–204

    Article  CAS  Google Scholar 

  • Kiyono M, Sone Y, Nakamura R, Pan-Hou H, Sakabe K (2009) The Mer E protein encoded by transposon Tn21 is a broad mercury transporter in Escherichia coli. FEBS Lett 583:1127–1131

    Article  PubMed  CAS  Google Scholar 

  • Kulshreshtha A, Agrawal R, Barar M, Saxena S (2014) A review on bioremediation of heavy metals in contaminated water. IOSR J Environ Sci Toxicol Food Tech (IOSR-JESTFT) 8(7) I):44–50

    Article  Google Scholar 

  • Layton AC, Chauhan A, Williams DE, Mailloux B, Knappett PS, Ferguson AS, McKay LD, lam MJ, Matin Ahmed K, Van Green A, Sayler GS (2014) Metagenomes of microbial communities in arsenic- and pathogen-contaminated well and surface water from Bangladesh. Genome Announc 2(6):e01170–e01114

    Article  PubMed  PubMed Central  Google Scholar 

  • Liu S, Zhang F, Chen J, Sun G (2011) Arsenic removal from contaminated soil via biovolatilization by genetically engineered bacteria under laboratory conditions. J Environ Sci 23(9):1544–1550

    Article  CAS  Google Scholar 

  • Lopez A, Lazaro N, Morales S, Marques AM (2002) Nickel biosorption by free and immobilized cells of Pseudomonas fluorescens4F39: a comparative study. Water Air Soil Pollut 135:157–172

    Article  CAS  Google Scholar 

  • Mahmood A, Malik RN (2014) Human health risk assessment of heavy metals via consumption of contaminated vegetables collected from different irrigation sources in Lahore, Pakistan. Arab J Chem 7(1):91–99

    Article  CAS  Google Scholar 

  • Malaviya P, Singh A (2014) Bioremediation of chromium solutions and chromium-containing wastewaters. Crit Rev Microbiol 42(4):607–633

    PubMed  Google Scholar 

  • Malik DS, Jain CK, Yadav AK (2017) Removal of heavy metals from emerging cellulosic low-cost adsorbents: a review. Appl Water Sci 7:2113–2136

    Article  CAS  Google Scholar 

  • Martinez RJ, Beazley MJ, Sobecky PA (2014) Phosphate-mediated remediation of metals and radionuclides. Advances in Ecology Article ID 786929, 1–14

  • Martinez-Finley EJ, Aschner M (2014) Recent advances in mercury research. Current Environmental Health Reports 1(2):163–171

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Naik MM, Dubey SK (2013) Lead resistant bacteria: lead resistance mechanisms, their applications in lead bioremediation and biomonitoring. Ecotoxicol Environ Saf 98:1–7

    Article  PubMed  CAS  Google Scholar 

  • Ng SP, Davis B, Polombo EA, Bhave M (2009) Tn5051 like mer containing transposon identified in a heavy metal tolerant strain Achromobacter sp. AO22 BMC Res Notes 7:2–38

    Google Scholar 

  • Olaniran AO, Balgobind A, Pillay B (2013) Bioavailability of heavy metals in soil: impact on microbial biodegradation of organic compounds and possible improvement strategies. Int J Mol Sci 14(5):10197–10228

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Parmar M, Thakur LS (2013) Heavy metal Cu, Ni and Zn: toxicity, health hazards and their removal techniques. Int J Plant Animal and Environ Sci 3(3):143–157

    CAS  Google Scholar 

  • Paul D, Poddar S, Sar P (2014) Characterization of arsenite-oxidizing bacteria isolated from arsenic-contaminated groundwater of West Bengal. Journal Of Environmental Science And Health Part A 49(13):1481–1492

    Article  CAS  Google Scholar 

  • Rabus R, Boll M, Heider J, Meckenstock RU, Buckel W, Einsle O, Ermler U, Golding BT, Gunsalus RP, Kroneck P, M H, Krüger M, Lueders T, Martins BM, Musat F, Richnow HH, Schink B, Seifert J, Szaleniec M, Treude T, Ullmann GM, Vogt C, von Bergen M, Wilkes H (2016) Anaerobic microbial degradation of hydrocarbons: from enzymatic reactions to the environment. J Mol Microbiol Biotechnol 26(1–3):5–28

    Article  PubMed  CAS  Google Scholar 

  • Ramamurthy AS, Memarian R (2012) Phytoremediation of mixed soil contaminants. Water Air & Soil Pollut 223(2):511–518

    Article  CAS  Google Scholar 

  • Ramasamy K, Kamaludeen, Banu SP (2007) Bioremediation of metals: microbial processes and techniques. In: Singh N, Tripathi R, editors. Environmental bioremediation technologies. Springer Berlin Heidelberg; 2007. p. 173–187

  • Rodriguez E, Santos C, Azevedo R, Mountinho-Pereira J, Correia C, Dias MC (2012) Chromium (VI) induces toxicity at different photosynthetic levels in pea. Plant Physiol & Biochem 53:94–100

    Article  CAS  Google Scholar 

  • Sarubbo LA, Rocha RB Jr, Luna JM, Rufino RD, Santos VA, Banat IM (2015) Some aspects of heavy metals contamination remediation and role of biosurfactants. Chem Ecol 31(8):707–723

    Article  CAS  Google Scholar 

  • Sasaki Y, Minakawa T, Miyazaki A, Silver S, Kusano T (2005) Functional dissection of a mercuric ion transporter MerC from Acidithiobacillus ferrooxidans. Biosci Biochem Biotech 69:1394–1402

    Article  CAS  Google Scholar 

  • Satyapal GK, Rani S, Kumar M, Kumar N (2016) Potential role of arsenic resistant bacteria in bioremediation: current status and future prospects. J Microb Biochem Technol 8:3

    Article  CAS  Google Scholar 

  • Sharma B, Singh S, Siddiqi NJ (2014) Biomedical implications of heavy metals induced imbalances in redox systems. BioMed Res Int Article ID 640754:1–26

    Google Scholar 

  • Singh JS, Abhilash PC, Singh HB, Singh RP, Singh DP (2011) Genetically engineered bacteria: an emerging tool for environmental remediation and future research perspectives. Gene 480:1–9

    Article  PubMed  CAS  Google Scholar 

  • Sinha RK, Valani D, Sinha S, Singh S, Herat S (2009) Bioremediation of contaminated sites: a low-cost nature’s biotechnology for environmental clean up by versatile microbes, plants & earthworms. Solid Waste Management and Environmental Remediation 1–72

  • Sone Y, Mochizuki Y, Koizawa K, Nakamura R, Pan-Hou H, Itoh T, Kiyono M (2013) Mercurial-resistance determinants in Pseudomonas strain k-62 plasmid pmr68. AMB Express 3:41

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Tang W, Shan B, Zhang H, Zhang W, Zhao Y, Ding Y, Rong N, Zhu X (2014) Heavy metal contamination in the surface sediments of representative limnetic ecosystems in eastern China. Sci Rep 4:7152

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Uqab B, Mudasir S, Nazir R (2016) Review on bioremediation of pesticides. J Bioremediat Biodegrad 7(3):1–5

    Google Scholar 

  • Wang J, Feng X, Anderson CWN, Xing Y, Shang L (2012) Remediation of mercury-contaminated sites—a review. J Hazardous Mat 221-222:1–18

    Article  CAS  Google Scholar 

  • Weber T, Thomas M (2017) Influence of ocean tides on the general ocean circulation in the early Eocene. Paleoceanography 32:553–570

    Article  Google Scholar 

  • WHO (2010) Preventing disease through healthy environments. Exposure to lead: a major public health concern

  • Wiatrowski HA, Ward PM, Barkay T (2006) Novel reduction of mercury(II) by mercury-sensitive dissimilatory metal reducing bacteria. Environ Sci Technol 40(21):6690–6696

    Article  PubMed  CAS  Google Scholar 

  • Xu R, Chen M, Fang T, Chen J (2017) A new method for extraction and heavy metals removal of abalone visceral polysaccharide. J Food Process Preserv 41:e13023

    Article  CAS  Google Scholar 

  • Yang L, Li X, Chu Z, Ren Y, Zhang J (2014) Distribution and genetic diversity of the microorganisms in the biofilter for the simultaneous removal of arsenic, iron and manganese from simulated groundwater. Bioresour Technol 156:384–388

    Article  PubMed  CAS  Google Scholar 

  • Yuan CG, Lu XF, Qin J, Rosen BP, Le XC (2008) Volatile arsenic species released from Escherichia coli expressing the AsIII S-adenosyl methionine methyl transferase gene. Environ Sci Technol 42:3201–3206

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Zhang R, Wilson VL, Hou A, Meng G (2015) Source of lead pollution, its influence on public health and the countermeasures. Int J of Health, Animal science and Food safety 2:18–31

    Google Scholar 

  • Zhao XW, Zhou MH, Li QBLYH, He N, Sun DH, Deng X (2005) Simultaneous mercury bioaccumulation and cell propagation by genetically engineered Escherichia coli. Process Biochem 40:1611–1616

    Article  CAS  Google Scholar 

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Acknowledgments

All content of the review article is fully acknowledged.

Funding

This study was funded by the National Science Foundation of China (31670117), the Science & Technology Project of Guangdong Province, China (2014A020217017), and the Guangdong Natural Science Foundation, China (2014A030313475).

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Authors and Affiliations

  1. Biology Department, College of Science, Shantou University, Shantou, 515063, China

    Amit Pratush & Zhong Hu

  2. Department of Microbiology, School of Biological Sciences, Faculty of Natural and Health Sciences, North-West University, Potchefstroom, 2735, South Africa

    Ajay Kumar

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  1. Amit Pratush
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  3. Zhong Hu
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Correspondence to Amit Pratush or Zhong Hu.

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Pratush, A., Kumar, A. & Hu, Z. Adverse effect of heavy metals (As, Pb, Hg, and Cr) on health and their bioremediation strategies: a review. Int Microbiol 21, 97–106 (2018). https://doi.org/10.1007/s10123-018-0012-3

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