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Design and fabrication of functional hydrogels through interfacial engineering

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Abstract

Hydrogels have drawn considerable attention in the past two decades due to their excellent biocompatibility and multi-stimuli responsiveness. They have a wide range of applications in the fields related to tissue engineering, sensors and biomedicine. Their applications are strongly influenced by the surface properties of hydrogels and the interfacial interactions between hydrogels and other substrates. In particular, the surface wettability and adhesion of hydrogels decide their applications as drug carriers and wound dressing materials. Nevertheless, there is a lack of systematic discussion on the surface functionalization strategies of hydrogels. Therefore, this review aims at summarizing the strategies of functionalizing the surfaces of hydrogels and bonding hydrogels with other solid substrates. It also explores the challenges and future perspectives of interfacial engineering of hydrogels.

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References

  1. Zorlutuna, P., Annabi, N., Camci-Unal, G., Nikkhah, M., Cha, J.M., Nichol, J.W., Manbachi, A., Bae, H., Chen, S. and Khademhosseini, A., Adv. Mater., 2012, 24: 1782

    Article  CAS  Google Scholar 

  2. Slaughter, B.V., Khurshid, S.S., Fisher, O.Z., Khademhosseini, A. and Peppas, N.A., Adv. Mater., 2009, 21: 3307

    Article  CAS  Google Scholar 

  3. Peppas, N.A., Hilt, J.Z., Khademhosseini, A. and Langer, R., Adv. Mater., 2006, 18: 1345

    Article  CAS  Google Scholar 

  4. Annabi, N., Tamayol, A., Uquillas, J.A., Akbari, M., Bertassoni, L.E., Cha, C., Camci-Unal, G., Dokmeci, M.R., Peppas, N.A. and Khademhosseini, A., Adv. Mater., 2014, 26: 85

    Article  CAS  Google Scholar 

  5. Sun, J.Y., Zhao, X., Illeperuma, W.R., Chaudhuri, O., Oh, K.H., Mooney, D.J., Vlassak, J.J. and Suo, Z., Nature, 2012, 489: 133

    Article  CAS  Google Scholar 

  6. Huang, T., Xu, H.G., Jiao, K.X., Zhu, L.P., Brown, H.R. and Wang, H.L., Adv. Mater., 2007, 19: 1622

    Article  CAS  Google Scholar 

  7. Gong, J.P., Katsuyama, Y., Kurokawa, T. and Osada, Y., Adv. Mater., 2003, 15: 1155

    Article  CAS  Google Scholar 

  8. Dai, X., Zhang, Y., Gao, L., Bai, T., Wang, W., Cui, Y. and Liu, W., Adv. Mater., 2015, 27: 3566

    Article  CAS  Google Scholar 

  9. Yang, W., Furukawa, H. and Gong, J.P., Adv. Mater., 2008, 20: 4499

    Article  CAS  Google Scholar 

  10. Liu, M., Ishida, Y., Ebina, Y., Sasaki, T., Hikima, T., Takata, M. and Aida, T., Nature, 2015, 517: 68

    Article  CAS  Google Scholar 

  11. Lin, P., Zhang, T., Wang, X., Yu, B. and Zhou, F., Small, 2016, 12: 4386

    Article  CAS  Google Scholar 

  12. Kim, Y.S., Liu, M., Ishida, Y., Ebina, Y., Osada, M., Sasaki, T., Hikima, T., Takata, M. and Aida, T., Nat. Mater., 2015, 14: 1002

    Article  CAS  Google Scholar 

  13. Choi, S. and Kim, J., J. Mater. Chem. B, 2015, 3: 1479

    Article  CAS  Google Scholar 

  14. Ma, C., Le, X., Tang, X., He, J., Xiao, P., Zheng, J., Xiao, H., Lu, W., Zhang, J., Huang, Y. and Chen, T., Adv. Funct. Mater., 2016, 26: 8670

    Article  CAS  Google Scholar 

  15. Zhang, R., Tang, M., Bowyer, A., Eisenthal, R. and Hubble, J., Biomaterials, 2005, 26: 4677

    Article  CAS  Google Scholar 

  16. Yan, B., Boyer, J.C., Habault, D., Branda, N.R. and Zhao, Y., J. Am. Chem. Soc., 2012, 134: 16558

    Article  CAS  Google Scholar 

  17. Wu, J. and Sailor, M.J., Adv. Funct. Mater., 2009, 19: 733

    Article  CAS  Google Scholar 

  18. Satarkar, N.S. and Hilt, J.Z., J. Control. Release, 2008, 130: 246

    Article  CAS  Google Scholar 

  19. Murdan, S., J. Control. Release, 2003, 92: 1

    Article  CAS  Google Scholar 

  20. Ma, C., Shi, Y., Pena, D.A., Peng, L. and Yu, G., Angew. Chem. Int. Ed., 2015, 54: 7376

    Article  CAS  Google Scholar 

  21. Le, X., Lu, W., Xiao, H., Wang, L., Ma, C., Zhang, J., Huang, Y. and Chen, T., ACS Appl. Mater. Interfaces, 2017, 9: 9038

    Article  CAS  Google Scholar 

  22. Kamata, H., Akagi, Y., Kayasuga-Kariya, Y., Chung, U.-i. and Sakai, T., Science, 2014, 343: 873

    Article  CAS  Google Scholar 

  23. Yuk, H., Zhang, T., Parada, G.A., Liu, X. and Zhao, X.H., Nat. Commun., 2016, 7: 12028

    Article  Google Scholar 

  24. Yao, X., Chen, L., Ju, J., Li, C., Tian, Y., Jiang, L. and Liu, M., Adv. Mater., 2016, 28: 7383

    Article  CAS  Google Scholar 

  25. Chen, L., Yao, X., Gu, Z., Zheng, K., Zhao, C., Lei, W., Rong, Q., Lin, L., Wang, J., Jiang, L. and Liu, M., Chem. Sci., 2017, 8: 2010

    Article  CAS  Google Scholar 

  26. Xu, L.N., Ma, P.P., Yuan, B., Chen, Q., Lin, S.C., Chen, X., Hua, Z.C. and Shen, J., RSC Adv., 2014, 4: 15030

    Article  CAS  Google Scholar 

  27. Xu, C., He, R., Xie, B., Ismail, M., Yao, C., Luan, J. and Li, X., J. Biomater. Sci. Polym. Ed., 2016, 27: 1354

    Article  CAS  Google Scholar 

  28. Deng, X., Korogiannaki, M., Rastegari, B., Zhang, J., Chen, M., Fu, Q., Sheardown, H., Filipe, C.D. and Hoare, T., ACS Appl. Mater. Interfaces, 2016, 8: 22064

    Article  CAS  Google Scholar 

  29. Shin, J., Lee, J.S., Lee, C., Park, H.J., Yang, K., Jin, Y., Ryu, J.H., Hong, K.S., Moon, S.H., Chung, H.M., Yang, H.S., Um, S.H., Oh, J.W., Kim, D.I., Lee, H. and Cho, S.W., Adv. Funct. Mater., 2015, 25: 3814

    Article  CAS  Google Scholar 

  30. Liu, Y., Meng, H., Konst, S., Sarmiento, R., Rajachar, R. and Lee, B.P., ACS Appl. Mater. Interfaces, 2014, 6: 16982

    Article  CAS  Google Scholar 

  31. Lee, Y.B., Shin, Y.M., Kim, E.M., Lim, J., Lee, J.Y. and Shin, H., Adv Healthcare Mater., 2016, 5: 2320

    Article  CAS  Google Scholar 

  32. Lee, Y.B., Shin, Y.M., Kim, E.M., Lee, J.Y., Lim, J., Kwon, S.K. and Shin, H., J. Mater. Chem. B, 2016, 4: 6012

    Article  CAS  Google Scholar 

  33. Han, L., Zhang, Y., Lu, X., Wang, K., Wang, Z. and Zhang, H., ACS Appl. Mater. Interfaces, 2016. 8: 29088

    Article  CAS  Google Scholar 

  34. Beckwith, K.M. and Sikorski, P., Biofabrication, 2013, 5: 045009

    Article  Google Scholar 

  35. Yuk, H., Zhang, T., Lin, S.T., Parada, G.A. and Zhao, X.H., Nat. Mater., 2016, 15: 190

    Article  CAS  Google Scholar 

  36. Muir, B.V., Myung, D., Knoll, W. and Frank, C.W., ACS Appl. Mater. Interfaces, 2014, 6: 958

    Article  CAS  Google Scholar 

  37. Liu, M., Ishida, Y., Ebina, Y., Sasaki, T. and Aida, T., Nat. Commun., 2013, 4: 2029

    Google Scholar 

  38. He, M., Jiang, H., Wang, R., Xie, Y., Zhao, W. and Zhao, C., J. Colloid Interface Sci., 2016, 484: 60

    Article  CAS  Google Scholar 

  39. Wen, L., Weaver, J.C. and Lauder, G.V., J. Exp. Biol., 2014, 217: 1656

    Article  Google Scholar 

  40. Liu, M., Wang, S. and Jiang, L., Mrs Bull., 2013, 38: 375

    Article  CAS  Google Scholar 

  41. Cai, Y., Lu, Q., Guo, X., Wang, S., Qiao, J. and Jiang, L., Adv. Mater., 2015, 27: 4162

    Article  CAS  Google Scholar 

  42. Cai, Y., Lin, L., Xue, Z.X., Liu, M.J., Wang, S.T. and Jiang, L., Adv. Funct. Mater., 2014, 24: 809

    Article  CAS  Google Scholar 

  43. Gould, J., Nature, 2015, 519: S2

    Article  CAS  Google Scholar 

  44. Ball, P., Nature, 1999, 400: 507

    Article  CAS  Google Scholar 

  45. Scholz, I., Barnes, W.J.P., Smith, J.M. and Baumgartner, W., J. Exp. Biol., 2009, 212: 155

    Article  Google Scholar 

  46. Chen, H., Zhang, P., Zhang, L., Liu, H., Jiang, Y., Zhang, D., Han, Z. and Jiang, L., Nature, 2016, 532: 85

    Article  CAS  Google Scholar 

  47. Bohn, H.F. and Federle, W., Proc. Natl. Acad. Sci. USA, 2004, 101: 14138

    Article  CAS  Google Scholar 

  48. Bauer, U. and Federle, W., Plant Signal. Behav., 2014, 4: 1019

    Article  Google Scholar 

  49. Liu, M., Wang, S., Wei, Z., Song, Y. and Jiang, L., Adv. Mater., 2009, 21: 665

    Article  CAS  Google Scholar 

  50. Lin, L., Liu, M., Chen, L., Chen, P., Ma, J., Han, D. and Jiang, L., Adv. Mater., 2010, 22: 4826

    Article  CAS  Google Scholar 

  51. Chen, L., Liu, M., Lin, L., Zhang, T., Ma, J., Song, Y. and Jiang, L., Soft Matter, 2010, 6: 2708

    Article  CAS  Google Scholar 

  52. Teng, C., Xie, D., Wang, J., Zhu, Y. and Jiang, L., J. Mater. Chem. A, 2016, 4: 12884

    Article  CAS  Google Scholar 

  53. Xue, Z., Wang, S., Lin, L., Chen, L., Liu, M., Feng, L. and Jiang, L., Adv. Mater., 2011, 23: 4270

    Article  CAS  Google Scholar 

  54. Lopez-Alemany, A., Compan, V. and Refojo, M.F., J. Biomed. Mater. Res., 2002, 63: 319

    Article  CAS  Google Scholar 

  55. Lai, Y.C. and Friends, G.D., J. Biomed. Mater. Res., 1997, 35: 349

    Article  CAS  Google Scholar 

  56. Yokota, M., Shimoyama, N., Fujisawa, K., Nakamura, M., Ajiro, H. and Akashi, M., Chem. Lett., 2011, 40: 1297

    Article  CAS  Google Scholar 

  57. Paradiso, P., Chu, V., Santos, L., Serro, A.P., Colaco, R. and Saramago, B., J. Biomed. Mater. Res. B, 2015, 103: 1059

    Article  CAS  Google Scholar 

  58. Beattie, T.K. and Tomlinson, A., Eye Contact Lens, 2009, 35: 316

    Article  Google Scholar 

  59. Thissen, H., Gengenbach, T., du Toit, R., Sweeney, D.F., Kingshott, P., Griesser, H.J. and Meagher, L., Biomaterials, 2010, 31: 5510

    Article  CAS  Google Scholar 

  60. Hasuda, H., Kwon, O.H., Kang, I.K. and Ito, Y., Biomaterials, 2005, 26: 2401

    Article  CAS  Google Scholar 

  61. Weis, K., Cell, 2007, 130: 405

    Article  CAS  Google Scholar 

  62. Walde, S. and Kehlenbach, R.H., Trends Cell Biol., 2010, 20: 461

    Article  Google Scholar 

  63. Liu, A.P. and Fletcher, D.A., Nat. Rev. Mol. Cell Biol., 2009, 10: 644

    Article  CAS  Google Scholar 

  64. Arumugam, S., Chwastek, G. and Schwille, P., Wiley Interdiscip. Rev.: Syst. Biol. Med., 2011, 3: 269

    Article  CAS  Google Scholar 

  65. Hu, X., Tan, H., Wang, X. and Chen, P., Colloids Surfaces A: Physicochem. Eng. Asp., 2016, 489: 297

    Article  CAS  Google Scholar 

  66. Oliveira, N.M., Zhang, Y.S., Ju, J., Chen, A.Z., Chen, Y., Sonkusale, S.R., Dokmeci, M.R., Reis, R.L., Mano, J.F. and Khademhosseini, A., Chem. Mater., 2016, 28: 3641

    Article  CAS  Google Scholar 

  67. Huang, X., Sun, Y. and Soh, S., Adv. Mater., 2015, 27: 4062

    Article  CAS  Google Scholar 

  68. Rose, S., Prevoteau, A., Elziere, P., Hourdet, D., Marcellan, A. and Leibler, L., Nature, 2014, 505: 382

    Article  CAS  Google Scholar 

  69. Lee, H., Dellatore, S.M., Miller, W.M. and Messersmith, P.B., Science, 2007, 318: 426

    Article  CAS  Google Scholar 

  70. Kato, M., Tsuboi, Y., Kikuchi, A. and Asoh, T.A., J. Phys. Chem. B, 2016, 120: 5042

    Article  CAS  Google Scholar 

  71. Zhang, H., Bian, C., Jackson, J.K., Khademolhosseini, F., Burt, H.M. and Chiao, M., ACS Appl. Mater. Interfaces, 2014, 6: 9126

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Key Laboratory of Bio-Inspired Smart Interfacial Science and Technology of Ministry of Education, School of Chemistry, Beihang University, Beijing, 100191, China

    Lie Chen, Yong-ai Yin, Yu-xia Liu & Ming-jie Liu  (刘明杰)

  2. International Research Institute for Multidisciplinary Science, Beihang University, Beijing, 100191, China

    Ming-jie Liu  (刘明杰)

  3. Engineering Research Center of Marine Biological Resource Comprehensive Utilization, State Oceanic Administration, The Third Institute of Oceanography of the State Oceanic Administration, Xiamen, 361005, China

    Ling Lin

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  1. Lie Chen
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  2. Yong-ai Yin
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  3. Yu-xia Liu
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  4. Ling Lin
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  5. Ming-jie Liu  (刘明杰)
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Correspondence to Ming-jie Liu  (刘明杰).

Additional information

This work was financially supported by the National Natural Science Foundation of China (No. 21574004), Xiamen Southern Oceanographic Center (No. 14GQT61HJ31), the 111 project (No. B14009), the Fundamental Research Funds for the Central Universities, the National ‘Young Thousand Talents Program’ and the Academic Excellence Foundation of BUAA for PHD Students.

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Chen, L., Yin, Ya., Liu, Yx. et al. Design and fabrication of functional hydrogels through interfacial engineering. Chin J Polym Sci 35, 1181–1193 (2017). https://doi.org/10.1007/s10118-017-1995-5

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  • DOI: https://doi.org/10.1007/s10118-017-1995-5

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