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Doxorubicin-loaded boron-rich polymer nanoparticles for orthotopically implanted liver tumor treatment

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Abstract

The in vivo behaviors of doxorubicin (DOX)-loaded dextran-poly(3-acrylamidophenylboronic acid) (Dextran-PAPBA) nanoparticles (NPs) were studied. The DOX-loaded NPs had a narrowly distributed diameter of ca. 74 nm and mainly accumulated in liver of tumor-bearing mice after intravenous injection as demonstrated by in vivo real-time near infrared fluorescent imaging. The DOX contents in various tissues were quantified and consisted well with the results of fluorescent imaging. The biodistribution pattern of DOX-loaded NPs encourages us to investigate their liver tumor treatment by using an orthotopically implanted liver tumor model, revealing that the DOX-loaded NPs formulation had better antitumor effect than free DOX.

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Authors and Affiliations

  1. Laboratory of Mesoscopic Chemistry and Department of Polymer Science & Engineering, College of Chemistry & Chemical Engineering; Jiangsu Provincial Laboratory for Nanotechnology, Nanjing University, Nanjing, 210093, China

    Lu-zhong Zhang, Ya-jun Zhang, Wei Wu  (武伟) & Xi-qun Jiang  (蒋锡群)

  2. Jiangsu Key Laboratory of Neuroregeneration, Nantong University, Nantong, 226001, China

    Lu-zhong Zhang

Authors
  1. Lu-zhong Zhang
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  2. Ya-jun Zhang
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  3. Wei Wu  (武伟)
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  4. Xi-qun Jiang  (蒋锡群)
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Corresponding authors

Correspondence to Wei Wu  (武伟) or Xi-qun Jiang  (蒋锡群).

Additional information

This work was financially supported by the National Natural Science Foundation of China (Nos. 51033002 and 51273090).

Invited paper dedicated to Professor Fosong Wang on the occasion of his 80th birthday

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Zhang, Lz., Zhang, Yj., Wu, W. et al. Doxorubicin-loaded boron-rich polymer nanoparticles for orthotopically implanted liver tumor treatment. Chin J Polym Sci 31, 778–786 (2013). https://doi.org/10.1007/s10118-013-1267-y

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  • DOI: https://doi.org/10.1007/s10118-013-1267-y

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