Skip to main content
SpringerLink
Log in

Poly(N-vinylpyrrolidone)-modified surfaces repel plasma protein adsorption

  • Papers
  • Published:
Chinese Journal of Polymer Science Aims and scope Submit manuscript

Abstract

The present work aimed to study the interaction between plasma proteins and PVP-modified surfaces under more complex protein conditions. In the competitive adsorption of fibrinogen (Fg) and human serum albumin (HSA), the modified surfaces showed preferential adsorption of HSA. In 100% plasma, the amount of Fg adsorbed onto PVP-modified surfaces was as low as 10 ng/cm2, suggesting the excellent protein resistance properties of the modified surfaces. In addition, immunoblots of proteins eluted from the modified surfaces after plasma contact confirmed that PVP-modified surfaces can repel most plasma proteins, especially proteins that play important roles in the process of blood coagulation.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. D’souza, A.J.M., Schowen, R.L. and Topp, E.M., J. Controlled Release, 2004, 94(1): 91

    Article  Google Scholar 

  2. Smith, L.E., Rimmer, S. and MacNeil, S., Biomaterials, 2006, 27(14): 2806

    Article  CAS  Google Scholar 

  3. Gaucher, G.v., Asahina, K., Wang, J. and Leroux, J. C., Biomacromolecules, 2009, 10(2): 408

    Article  CAS  Google Scholar 

  4. Hong, Y., Chirila, T.V., Vijayasekaran, S., Shen, W.Y., Lou, X. and Dalton, P.D., J. Biomed. Mater. Res., 1998, 39(4): 650

    Article  CAS  Google Scholar 

  5. Knappe, P., Bienert, R., Weidner, S. and Thunemann, A.F., Polymer, 2010, 51(8): 1723

    Article  CAS  Google Scholar 

  6. Chapiro, A., Foex-Millequant, M., Jendrychowska-Bonamour, A.M., Lerke, Y., Sadurni, P. and Domurado, D., Radiat. Phys. Chem., 1980, 15(2–3): 423

    CAS  Google Scholar 

  7. Higuchi, A., Shirano, K., Harashima, M., Yoon, B.O., Hara, M., Hattori, M. and Imamura, K., Biomaterials, 2002, 23(13): 2659

    Article  CAS  Google Scholar 

  8. Xu, M., Qiu, J.F., Lin, Y.M., Shi, X.H., Chen, H.J. and Xiao, T., Colloids Surf., B, 2010, 80(2): 200

    Article  CAS  Google Scholar 

  9. Telford, A.M., James, M., Meagher, L. and Neto, C., ACS Appl. Mat. Interfaces, 2010, 2(8): 2399

    Article  CAS  Google Scholar 

  10. Wu, Z.Q., Chen, H., Liu, X.L., Zhang, Y.X., Li, D. and Huang, H., Langmuir, 2009, 25(5): 2900

    Article  CAS  Google Scholar 

  11. Hay, R.W., Lawrance, G.A. and Curtis, N.F., J. Chem. Soc., Perkin Trans. 1, 1975, (6): 591

    Article  Google Scholar 

  12. Contreras, M.A., Bale, W.F. and Spar, I.L., Methods Enzymol, 1983, 92: 277

    Article  CAS  Google Scholar 

  13. Cornelius, R.M. and Brash, J.L., J. Biomater. Sci., Polym. Ed., 1993, 4(3): 291

    Article  CAS  Google Scholar 

  14. Li, D., Chen, H., McClung, W.G. and Brash, J.L., Acta Biomater., 2009, 5(6): 1864

    Article  CAS  Google Scholar 

  15. Unsworth, L.D., Sheardown, H. and Brash, J.L., Langmuir, 2005, 21(3): 1036

    Article  CAS  Google Scholar 

  16. Siegismund, D., Keller, T.F., Jandt, K.D. and Rettenmayr, M., Macromol. Biosci., 2010, 10(10): 1216

    Article  CAS  Google Scholar 

  17. Zheng, J., Li, L., Tsao, H. K., Sheng, Y. J., Chen, S. and Jiang, S., Biophys. J., 2005, 89(1): 158

    Article  CAS  Google Scholar 

  18. He, Y., Chang, Y., Hower, J.C., Zheng, J., Chen, S. and Jiang, S., Phys. Chem. Chem. Phys., 2008, 10(36): 5539

    Article  CAS  Google Scholar 

  19. Sethuraman, A., Han, M., Kane, R.S. and Belfort, G., Langmuir, 2004, 20(18): 7779

    Article  CAS  Google Scholar 

  20. Green, R.J., Davies, M.C., Roberts, C.J. and Tendler, S.J.B., Biomaterials, 1999, 20(4): 385

    Article  CAS  Google Scholar 

  21. Munro, M.S., Quattrone, A.J., Ellsworth, S.R., Kulkarni, P. and Eberhart, R.C., Trans. Am. Soc. Artif. Intern. Organs, 1981, 27: 499

    CAS  Google Scholar 

  22. Archambault, J.G. and Brash, J.L., Colloids Surf., B, 2004, 39(1–2): 9

    Article  CAS  Google Scholar 

  23. Brash, J.L. and ten Hove, P., Thromb Haemost, 1984, 51(3): 326

    CAS  Google Scholar 

  24. Jo, S. and Park, K., Biomaterials, 2000, 21(6): 605

    Article  CAS  Google Scholar 

  25. Chen, H., Zhang, Z., Chen, Y., Brook, M.A. and Sheardown, H., Biomaterials, 2005, 26(15): 2391

    Article  CAS  Google Scholar 

  26. Feng, W., Zhu, S.P., Ishihara, K. and Brash, J.L., Biointerphases, 2006, 1(1): 50

    Article  CAS  Google Scholar 

  27. Dyer, M.A., Ainslie, K.M. and Pishko, M.V., Langmuir, 2007, 23(13): 7018

    Article  CAS  Google Scholar 

  28. Unsworth, L.D., Sheardown, H. and Brash, J.L., Biomaterials, 2005, 26(30): 5927

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. School of Materials Science and Engineering, Wuhan University of Technology, Wuhan, 430070, China

    Xiao-li Liu & Dan Li

  2. College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Soochow, 215123, China

    Xiao-li Liu, Zhao-qiang Wu  (武照强), Dan Li & Hong Chen

Authors
  1. Xiao-li Liu
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Zhao-qiang Wu  (武照强)
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Dan Li
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Hong Chen
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Zhao-qiang Wu  (武照强).

Additional information

This work is financially supported by the National Natural Science Foundation of China (Nos. 20974086, 20974122 and 20920102035), the Ministry of Education of China (209151), the Scientific Research Foundation for the Returned Overseas Chinese Scholars and State Education Ministry.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Liu, Xl., Wu, Zq., Li, D. et al. Poly(N-vinylpyrrolidone)-modified surfaces repel plasma protein adsorption. Chin J Polym Sci 30, 235–241 (2012). https://doi.org/10.1007/s10118-012-1118-2

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10118-012-1118-2

Keywords

Search

Navigation