Skip to main content

Advertisement

SpringerLink
Log in

Clinical significance of nontuberculous mycobacteria isolates in elderly Taiwanese patients

  • Article
  • Published:
European Journal of Clinical Microbiology & Infectious Diseases Aims and scope Submit manuscript

Abstract

The aim of this study was to investigate the clinical significance of nontuberculous mycobacteria (NTM) isolates in elderly Taiwanese patients. From 2004 through 2008, patients >65 years old with NTM isolation were identified. The definitions of NTM disease followed the American Thoracic Society and Infectious Disease Society of America (ATS/IDSA) criteria. Among the 3,175 NTM isolates, Mycobacterium avium complex (MAC; n = 1,118, 35.2%) was the most prevalent species, followed by M. abscessus (n = 545, 17.2%). Among the 1,633 elderly patients with NTM isolates, the most prevalent NTM species were MAC (n = 592, 36.3%) and M. fortuitum complex (n = 311, 19.0%). NTM colonization was found in 1,339 (80.4%) patients and only 326 (19.6%) patients had NTM diseases. During the study period, the annual incidence rates (per 100,000 inpatients and outpatients) of NTM colonization and disease both increased significantly (p < 0.0001) from 10.5 to 15.8 and from 2.1 to 4.3, respectively. Isolated pulmonary NTM infections compromised 294 (90.2%) of the 326 elderly cases of NTM disease. In conclusion, this study found an increasing trend in the incidence of both NTM isolates and NTM diseases among elderly Taiwanese patients. MAC and M. abscessus were the most frequent species causing various types of NTM disease.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

Similar content being viewed by others

References

  1. Somoskovi A, Mester J, Hale YM, Parsons LM, Salfinger M (2002) Laboratory diagnosis of nontuberculous mycobacteria. Clin Chest Med 23:585–597

    Article  PubMed  Google Scholar 

  2. Khan K, Wang J, Marras TK (2007) Nontuberculous mycobacterial sensitization in the United States: national trends over three decades. Am J Respir Crit Care Med 176:306–313

    Article  PubMed  Google Scholar 

  3. Wolinsky E (1979) Nontuberculous mycobacteria and associated diseases. Am Rev Respir Dis 119:107–159

    PubMed  CAS  Google Scholar 

  4. Vu TT, Daniel SJ, Quach C (2005) Nontuberculous mycobacteria in children: a changing pattern. J Otolaryngol 34:S40–S44

    PubMed  Google Scholar 

  5. Horsburgh CR Jr (1996) Epidemiology of disease caused by nontuberculous mycobacteria. Semin Respir Infect 11:244–251

    PubMed  Google Scholar 

  6. Griffith DE, Aksamit T, Brown-Elliott BA, Catanzaro A, Daley C, Gordin F, Holland SM, Horsburgh R, Huitt G, Iademarco MF, Iseman M, Olivier K, Ruoss S, von Reyn CF, Wallace RJ Jr, Winthrop K; ATS Mycobacterial Diseases Subcommittee; American Thoracic Society; Infectious Disease Society of America (2007) An official ATS/IDSA statement: diagnosis, treatment, and prevention of nontuberculous mycobacterial diseases. Am J Respir Crit Care Med 175:367–416

    Article  PubMed  CAS  Google Scholar 

  7. British Thoracic Society (2000) Management of opportunist mycobacterial infections: Joint Tuberculosis Committee Guidelines 1999. Thorax 55:210–218

    Article  Google Scholar 

  8. Lai CC, Tan CK, Chou CH, Hsu HL, Liao CH, Huang YT, Yang PC, Luh KT, Hsueh PR (2010) Increasing incidence of nontuberculous mycobacteria, Taiwan, 2000–2008. Emerg Infect Dis 16:294–296

    PubMed  Google Scholar 

  9. Prevots DR, Shaw PA, Strickland D, Jackson LA, Raebel MA, Blosky MA, Montes de Oca R, Shea YR, Seitz AE, Holland SM, Olivier KN (2010) Nontuberculous mycobacterial lung disease prevalence at four integrated health care delivery systems. Am J Respir Crit Care Med 182:970–976

    Article  PubMed  Google Scholar 

  10. Cassidy PM, Hedberg K, Saulson A, McNelly E, Winthrop KL (2009) Nontuberculous mycobacterial disease prevalence and risk factors: a changing epidemiology. Clin Infect Dis 49:e124–129

    Article  PubMed  Google Scholar 

  11. Andréjak C, Thomsen VØ, Johansen IS, Riis A, Benfield TL, Duhaut P, Sørensen HT, Lescure FX, Thomsen RW (2010) Nontuberculous pulmonary mycobacteriosis in Denmark: incidence and prognostic factors. Am J Respir Crit Care Med 181:514–521

    Article  PubMed  Google Scholar 

  12. Roberts GD, Koneman EW, Kim YK (1991) Mycobacterium. In: Balows A, Hausler WJ Jr, Herrmann KL, Isenberg HD, Shadomy HJ (eds) Manual of clinical microbiology, 5th edn. American Society for Microbiology, Washington, DC, pp 304–339

    Google Scholar 

  13. Hernández-Garduño E, Rodrigues M, Elwood RK (2009) The incidence of pulmonary non-tuberculous mycobacteria in British Columbia, Canada. Int J Tuberc Lung Dis 13:1086–1093

    PubMed  Google Scholar 

  14. Hsueh PR, Liu YC, So J, Liu CY, Yang PC, Luh KT (2006) Mycobacterium tuberculosis in Taiwan. J Infect 52:77–85

    Article  PubMed  Google Scholar 

  15. Ding LW, Lai CC, Lee LN, Hsueh PR (2006) Disease caused by non-tuberculous mycobacteria in a university hospital in Taiwan, 1997–2003. Epidemiol Infect 134:1060–1067

    Article  PubMed  CAS  Google Scholar 

  16. Parrish SC, Myers J, Lazarus A (2008) Nontuberculous mycobacterial pulmonary infections in non-HIV patients. Postgrad Med 120:78–86

    Article  PubMed  Google Scholar 

  17. Winthrop KL, McNelley E, Kendall B, Marshall-Olson A, Morris C, Cassidy M, Saulson A, Hedberg K (2010) Pulmonary nontuberculous mycobacterial disease prevalence and clinical features: an emerging public health disease. Am J Respir Crit Care Med 182:977–982

    Article  PubMed  Google Scholar 

  18. Serra C, Loi G, Saddi B, Pautasso M, Manzin A (2007) Unusual clinical presentation of Mycobacterium fortuitum infection in an immunocompetent woman. J Clin Microbiol 45:1663–1665

    Article  PubMed  Google Scholar 

  19. Keller M, Mak A, Thibert L, Rene P, Klein MB (2008) Mycobacterium haemophilum epididymal abscess in a renal transplant patient. J Clin Microbiol 46:2459–2460

    Article  PubMed  Google Scholar 

  20. Fox R, Mears J (2004) Female genital tract Mycobacterium chelonae infection. J Obstet Gynaecol 24:326

    Article  PubMed  CAS  Google Scholar 

  21. Huang CT, Chen CY, Chen HY, Chou CH, Ruan SY, Lai CC, Hsueh PR (2010) Genitourinary infections caused by nontuberculous mycobacteria at a university hospital in Taiwan, 1996–2008. Clin Microbiol Infect 16:1585–1590

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Intensive Care Medicine, Chi Mei Medical Center, Liouying, Tainan, Taiwan

    C.-C. Lai & W. L. Liu

  2. Department of Intensive Care Medicine, Chi-Mei Medical Center, Tainan, Taiwan

    C. K. Tan

  3. Department of Internal Medicine, Taipei County Hospital, Taipei County, Taiwan

    S. H. Lin

  4. Department of Internal Medicine, Far Eastern Memorial Hospital, Taipei, Taiwan

    C. H. Liao

  5. Departments of Laboratory Medicine and Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan

    Y. T. Huang & P. R. Hsueh

Authors
  1. C.-C. Lai
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. C. K. Tan
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. S. H. Lin
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. W. L. Liu
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. C. H. Liao
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Y. T. Huang
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. P. R. Hsueh
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to P. R. Hsueh.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Lai, CC., Tan, C.K., Lin, S.H. et al. Clinical significance of nontuberculous mycobacteria isolates in elderly Taiwanese patients. Eur J Clin Microbiol Infect Dis 30, 779–783 (2011). https://doi.org/10.1007/s10096-011-1155-8

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10096-011-1155-8

Keywords

Search

Navigation